Results 21 to 30 of about 286,131 (311)

TMEPAI/PMEPA1 Is a Positive Regulator of Skeletal Muscle Mass [PDF]

Frontiers in Physiology, 2020
Inhibition of myostatin- and activin-mediated SMAD2/3 signaling using ligand traps, such as soluble receptors, ligand-targeting propeptides and antibodies, or follistatin can increase skeletal muscle mass in healthy mice and ameliorate wasting in models of cancer cachexia and muscular dystrophy.
Adam Hagg, Adam Hagg, Adam Hagg, Swati Kharoud, Swati Kharoud, Georgia Goodchild, Craig A. Goodman, Craig A. Goodman, Justin L. Chen, Justin L. Chen, Rachel E. Thomson, Rachel E. Thomson, Hongwei Qian, Hongwei Qian, Paul Gregorevic, Paul Gregorevic, Paul Gregorevic, Paul Gregorevic, Craig A. Harrison, Craig A. Harrison, Kelly L. Walton, Kelly L. Walton   +21 more
openaire   +6 more sources

Skeletal muscle mTORC1 regulates whole-body metabolism [PDF]

, 2015
Skeletal muscle, which represents over 40% of the total body mass, is a dynamic tissue with a key role in the maintenance of metabolic homeostasis. Several lines of evidence indicate that alterations of the normal muscle function, as for example in ...
Ormazabal, Maitea Guridi
core   +1 more source

Associations of pyrethroids exposure with skeletal muscle strength and mass

Environmental Science and Pollution Research, 2023
Abstract This study aimed to examine the associations of pyrethroids exposure with handgrip strength and skeletal muscle mass and potential modification effects in US adults. The data from the National Health and Nutrition Examination Survey 1999–2014 was used.
Zhenger Fang, Xia Chen, Mingliang Liu, Lei Zuo, Biying Zhou, Guangjun Zheng, Haiyan Chen, Guang Hao   +7 more
openaire   +2 more sources

Regulation of skeletal muscle plasticity by the transcriptional coregulators PGC-1α and NCoR1 [PDF]

, 2013
Skeletal muscle plasticity is regulated by a wide range of factors, among which environmental stimuli such as exercise play a central role. Importantly, changes in skeletal muscle phenotype exert a direct impact on health and risk to premature death.
Pérez-Schindler, Joaquín
core   +1 more source

Role of microRNAs in skeletal muscle hypertrophy

Frontiers in Physiology, 2014
Skeletal muscle comprises approximately 40% of body weight, and is important for locomotion, as well as for metabolic homeostasis. Adult skeletal muscle mass is maintained by a fine balance between muscle protein synthesis and degradation. In response to
Keisuke eHitachi, Kunihiro eTsuchida
doaj   +1 more source

p21-Activated Kinase 1 Is Permissive for the Skeletal Muscle Hypertrophy Induced by Myostatin Inhibition

Frontiers in Physiology, 2021
Skeletal muscle, the most abundant tissue in the body, plays vital roles in locomotion and metabolism. Understanding the cellular processes that govern regulation of muscle mass and function represents an essential step in the development of therapeutic ...
Caroline Barbé, Audrey Loumaye, Pascale Lause, Olli Ritvos, Jean-Paul Thissen   +4 more
doaj   +1 more source

Myostatin and the control of skeletal muscle mass

Current Opinion in Genetics & Development, 1999
The mechanisms by which tissue size is controlled are poorly understood. Over 30 years ago, Bullough proposed the existence of chalones, which act as tissue-specific negative growth regulators. The recent discovery of myostatin suggests that negative regulation of tissue growth may be an important mechanism for controlling skeletal muscle mass and ...
S J, Lee, A C, McPherron
openaire   +2 more sources

Signaling pathways controlling skeletal muscle mass [PDF]

Critical Reviews in Biochemistry and Molecular Biology, 2013
The molecular mechanisms underlying skeletal muscle maintenance involve interplay between multiple signaling pathways. Under normal physiological conditions, a network of interconnected signals serves to control and coordinate hypertrophic and atrophic messages, culminating in a delicate balance between muscle protein synthesis and proteolysis. Loss of
Egerman, Marc A., Glass, David J.
openaire   +2 more sources

Fat oxidation, fitness and skeletal muscle expression of oxidative/lipid metabolism genes in South Asians: implications for insulin resistance? [PDF]

, 2010
<p><b>Background:</b> South Asians are more insulin resistant than Europeans, which cannot be fully explained by differences in adiposity. We investigated whether differences in oxidative capacity and capacity for fatty acid utilisation
Nita G Forouhi, Jason M R Gill, Hall, L.M.L., Hariharan, Narayanan, Salt, I.P., Hall, Lesley M L, Wilson, John, Niall G. MacFarlane, Niall G MacFarlane, Sattar, N., Milne, Gillian R, Gillian R Milne, MacFarlane, N.G., Gill, Jason M R, Gill Jason M. R., Lesley M. L. Hall, Moran Colin N., John Wilson, Sattar Naveed, Jason M. R. Gill, Colin N Moran, Gillian R. Milne, MacFarlane Niall G., Lesley M L Hall, Forouhi, N.G., MacFarlane, Niall G, Hariharan, N., Ian P Salt, Colin N. Moran, Hariharan Narayanan, Milne, G.R., Sattar, Naveed, Gill, J.M.R., Moran, C.N., Milne Gillian R., Nita G. Forouhi, Forouhi Nita G., Salt Ian P., Naveed Sattar, Narayanan Hariharan, Moran, Colin Neil, Hall Lesley M. L., Forouhi, Nita G, Salt, Ian P, Ian P. Salt, Wilson John   +45 more
core   +1 more source

Effect of Skeletal Muscle and Fat Mass on Muscle Strength in the Elderly [PDF]

Healthcare, 2018
It is important for elderly people to maintain or improve muscle strength and for clinicians to know the factors that affect muscle strength. Therefore, the purpose of this study was to compare the effects of fat mass (FM) and skeletal muscle mass (SMM) on muscle strength. The participants included 192 community-dwelling elderly women.
Koji Nonaka, Shin Murata, Kayoko Shiraiwa, Teppei Abiko, Hideki Nakano, Hiroaki Iwase, Koichi Naito, Jun Horie   +7 more
openaire   +2 more sources