Results 31 to 40 of about 286,131 (311)

Editorial: Emerging Mechanisms for Skeletal Muscle Mass Regulation [PDF]

Frontiers in Cell and Developmental Biology, 2021
Skeletal muscle is considered an essential tissue involved in many physiological functions such as metabolism, thermoregulation, respiration, and locomotion. It has become clear that genetic and environmental factors are intricately involved in regulating skeletal muscle volume or myofiber size.
Ogura, Yuji, Sato, Shuichi, Gallot, Yann, Arthur, Susan   +3 more
openaire   +3 more sources

Molecular brakes regulating mTORC1 activation in skeletal muscle following synergist ablation [PDF]

, 2014
The goal of the current work was to profile positive (mTORC1 activation, autocrine/paracrine growth factors) and negative [AMPK, unfolded protein response (UPR)] pathways that might regulate overload-induced mTORC1 activation with the hypothesis that a ...
Hamilton, D. Lee, Gallagher, Iain J, Philp, A., Baar, Keith, Towler, Mhairi C., Bodine, S. C., Gallagher, Iain J., Philp, Andrew, Towler, M. C., Baar, K., Towler, Mhairi C, Mackenzie, M. G., Gallagher, I. J., Patton, Amy, Hamilton, David Lee, Patton, A., MacKenzie, Matthew G., Lee Hamilton, D., Bodine, Sue C, Bodine, Sue C., MacKenzie, Matthew G   +20 more
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Mouse skeletal muscle fiber-type-specific macroautophagy and muscle wasting are regulated by a Fyn/STAT3/Vps34 signaling pathway [PDF]

, 2012
Skeletal muscle atrophy induced by aging (sarcopenia), inactivity, and prolonged fasting states (starvation) is predominantly restricted to glycolytic type II muscle fibers and typical spares oxidative type I fibers.
Bastie, Claire C., Claire C. Bastie, Jeffrey E. Pessin, Ana Maria Cuervo, Yichen Wang, Eijiro Yamada, Hiroshi Koga, Yamada, Eijiro, Eijiro Yamada, Koga, Hiroshi, Wang, Yichen, Cuervo, Ana Maria, Pessin, Jeffrey E.   +12 more
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TAK1 preserves skeletal muscle mass and mitochondrial function through redox homeostasis

FASEB BioAdvances, 2020
Skeletal muscle atrophy is debilitating consequence of a large number of chronic disease states, aging, and disuse conditions. Skeletal muscle mass is regulated through coordinated activation of a number of signaling cascades.
Anirban Roy, Aditya K. Sharma, Kushal Nellore, Vihang A Narkar, Ashok Kumar   +4 more
doaj   +1 more source

Obesity is associated with improved postoperative overall survival, independent of skeletal muscle mass in lung adenocarcinoma

Journal of Cachexia, Sarcopenia and Muscle, 2022
Background Although the obesity paradox is a topic of immense interest for oncologists and epidemiologists, the mechanism underlying this unexpected benefit of obesity is poorly understood.
Ji Hyun Lee, Young Cheol Yoon, Hyun Su Kim, Min Jae Cha, Jae‐Hun Kim, Kyunga Kim, Hye Seung Kim   +6 more
doaj   +1 more source

Effects of alfacalcidol on circulating cytokines and growth factors in rat skeletal muscle [PDF]

, 2011
Supra-physiological levels of vitamin D induce skeletal muscle atrophy, which may be particularly detrimental in already sarcopaenic elderly. Neither the cause nor whether the atrophy is fibre type specific are known.
Jaspers, R.T., Rittweger, Jörn, Janwillem Testerink, Richard T. Jaspers, Hans Degens, Testerink, J., Degens, Hans, Jörn Rittweger, Degens, H., de Haan, A., de Haan, Arnold, Jaspers, Richard, Haan, A. de, Testerink, Janwillem, Arnold de Haan, Rittweger, J.   +15 more
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The transcriptional coactivator PGC-1α is dispensable for chronic overload-induced skeletal muscle hypertrophy and metabolic remodeling [PDF]

, 2013
Skeletal muscle mass loss and dysfunction have been linked to many diseases. Conversely, resistance exercise, mainly by activating mammalian target of rapamycin complex 1 (mTORC1), promotes skeletal muscle hypertrophy and exerts several therapeutic ...
Handschin, Christoph, Santos, Gesa, Zorzato, Francesco, Perez-Schindler, J, Zorzato, F, Summermatter, S, Summermatter, Serge, Santos, G, Pérez-Schindler, Joaquín, Handschin, C   +9 more
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Differential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophy [PDF]

, 2013
BACKGROUND: Skeletal muscle mass is determined by the balance between protein synthesis and degradation. Mammalian target of rapamycin complex 1 (mTORC1) is a master regulator of protein translation and has been implicated in the control of muscle mass ...
Handschin, Christoph, Bentzinger, C. Florian, Guridi, Maitea, Castets, Perrine, Hall, Michael N, Tintignac, Lionel A., Hall, Michael N., Perrine Castets, Romanino, Klaas, Tintignac, Lionel, Rüegg, Markus A, Michael N Hall, Lin, Shuo, Markus A Rüegg, Bentzinger, C Florian, Christoph Handschin, Serge Summermatter, Summermatter, Serge, C Bentzinger, Klaas Romanino, Maitea Guridi, Shuo Lin, Rüegg, Markus A., Lionel A Tintignac   +23 more
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Phenotype selection reveals coevolution of muscle glycogen and protein and PTEN as a gate keeper for the accretion of muscle mass in adult female mice. [PDF]

, 2012
We have investigated molecular mechanisms for muscle mass accretion in a non-inbred mouse model (DU6P mice) characterized by extreme muscle mass. This extreme muscle mass was developed during 138 generations of phenotype selection for high protein ...
Hammon Harald M., Bidlingmaier, Martin, Bernhard G Baumgartner, Andreas Hoeflich, Zeissler, Anja, Brenig Bertram, Binder Gerhard, Sawitzky, Mandy, Christ Bruno, Binder, Gerhard, Bidlingmaier Martin, Stock Peggy, Metzger, Friedrich, Christ, Bruno, Bertram Brenig, Renne Ulla, Bielohuby Maximilian, Cornelia C Metges, Zeissler Anja, Sawitzky Mandy, Barbara J M Stoehr, Hoeflich Andreas, Metges, Cornelia C., Solvig Görs, Anja Zeissler, Gerhard Binder, Brenig, Bertram, Stoehr, Barbara J. M., Fromm-Dornieden Carolin, Görs, Solvig, Bielohuby, Maximilian, Stock, Peggy, Hammon, Harald M., Hoeflich, Andreas, Stoehr Barbara J. M., Harald M Hammon, Fromm-Dornieden, Carolin, Friedrich Metzger, Langhammer, Martina, Martina Langhammer, Metges Cornelia C., Langhammer Martina, Martin Bidlingmaier, Renne, Ulla, Görs Solvig, Mandy Sawitzky, Peggy Stock, Maximilian Bielohuby, Baumgartner, Bernhard G., Ulla Renne, Carolin Fromm-Dornieden, Baumgartner Bernhard G., Bruno Christ, Metzger Friedrich   +53 more
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Function of mTOR complex 1 and 2 in skeletal muscle [PDF]

, 2009
Growth of an organ during development and during adaptation in the adult can be controlled by alterations either in the number or the size of cells. The two mechanisms are fundamentally different and require distinct regulation.
Bentzinger, Conrad Florian
core   +1 more source