Results 31 to 40 of about 187,636 (307)
ToxicsOccupational exposure as a firefighter was recently classified as carcinogenic to humans by the IARC. Fire instructors’ exposure to carcinogenic PAHs is a major concern, and studies that have tried to assess the determinants of their exposure are scarce.
Pauline Zangl +2 more
doaj +1 more source
Molecular Oncology, EarlyView.We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau +11 more
wiley +1 more source
Toxics, 2022 The cosmetic industry has flourished in recent years. Accordingly, the safety of cosmetic ingredients is increasing. Bromochlorophene (BCP) is a commonly used cosmetic preservative.
Yong-Jae Lee +4 more
doaj +1 more source
The Absorption of Monomethylhydrazine through Canine Skin
Experimental Biology and Medicine, 1969 SummaryGraded doses of monomethylhydrazine (MMH) were applied to a 300-cm2 area of the shaved chest of anesthetized dogs. The area of skin to which the MMH was applied was reddened within 5 min, and the color progressively changed to deep red, then to yellow-brown to dark purple and, after 6 hr, to light gray.
Dale A. Clark, Edwin B. Smith
openaire +3 more sources
Exploring the role of cyclin D1 in the pathogenesis of multiple myeloma beyond cell cycle regulation
Molecular Oncology, EarlyView.Cyclin D1 overexpression altered the cell adhesion pathway, while cyclin D2 upregulation had less impact on pathway enrichment analysis. Multiple myeloma (MM) patients with cyclin D1 overexpression showed reduced CD56 expression and increased circulating tumor cells (CTC) levels, suggesting that cyclin D1 may contribute to MM cell dissemination ...
Ignacio J. Cardona‐Benavides +13 more
wiley +1 more source
Evaluation of the Percutaneous Absorption of Drug Molecules in Zebrafish
Molecules, 2020 In recent decades, zebrafish (Danio rerio) has become a widely used vertebrate animal model for studying development and human diseases. However, studies on skin medication using zebrafish are rare.
Daizo Morikane +2 more
doaj +1 more source
Temperature induced changes in the optical properties of skin in vivo
Scientific Reports, 2021 Knowledge of temperature-induced changes of skin optical properties is required for accurate dosimetry of photothermal treatments. We determined and compared in vivo optical properties of mouse ear skin at different temperatures. The diffuse reflectance,
Tyler W. Iorizzo +4 more
doaj +1 more source
Human skin absorption of three phthalates [PDF]
Toxicology LettersPopulation studies reveal widespread exposure to phthalates. Understanding their absorption, distribution, metabolism, and excretion is vital to reduce exposure. However, data on skin absorption remain limited. We thus aim to characterize the skin permeation of three phthalates in a mixture, neat or in emulsion; di(2-ethylhexyl) phthalate (d4-DEHP ...
Hopf, N.B. +7 more
openaire +2 more sources
Ro 31‐8220 suppresses bladder cancer progression via enhancing autophagy in vitro and in vivo
FEBS Open Bio, EarlyView.The pan‐protein kinase C inhibitor Ro‐31‐8220 demonstrates potent anti‐bladder cancer effects both in vitro and in vivo by suppressing migration/invasion, inducing apoptosis and crucially activating autophagy, where blocking autophagy with chloroquine reduces its cell‐killing efficacy, suggesting its promise as a novel therapeutic candidate requiring ...
Shengjun Fu +12 more
wiley +1 more source
Advanced Biology, EarlyView.The regenerative potential of adipose tissue‐derived stem cells can be enhanced through chemical stimulation in vitro. A short stimulation protocol using forskolin, either alone or in combination with other growth factors, under xeno‐free conditions enhanced the pro‐angiogenic responses in human ASCs.
Maria Vittoria Giraudo +5 more
wiley +1 more source