Results 41 to 50 of about 492,394 (350)
In vitro and ex-vivo evaluation of topical formulations designed to minimize transdermal absorption of Vitamin K1. [PDF]
PLoS ONE, 2018 Topical application of Vitamin K1 has been demonstrated to effectively treat papulopustular skin rash, a serious and frequently encountered side effect of Epidermal Growth Factor Inhibitors (EGFRIs).
Ramina Nabiee +5 more
doaj +1 more source
N-alkylamides : from plant to brain [PDF]
, 2014 Background: Plant N-alkylamides (NAAs) are bio-active compounds with a broad functional spectrum. In order to reach their pharmacodynamic targets, they have to overcome several barriers of the body in the absorption phase.
De Spiegeleer, Bart +6 more
core
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Permeability of frog skin to chemicals: effect of penetration enhancers
Heliyon, 2019 Rarely do commercial chemical products contain solely the active chemical/ingredient. It is therefore important to consider whether ingredients other than the active may: 1) alter absorption of the active chemical, or 2) be absorbed themselves, resulting
Victoria K. Llewelyn +2 more
doaj +1 more source
Giant microwave absorption in fine powders of superconductors [PDF]
, 2018 Enhanced microwave absorption, larger than that in the normal state, is observed in fine grains of type-II superconductors (MgB$_2$ and K$_3$C$_{60}$) for magnetic fields as small as a few $\%$ of the upper critical field.
Bud’ko, Sergey +11 more
core +3 more sources
A two-dimensional mathematical model of percutaneous drug absorption [PDF]
, 2004 Background When a drug is applied on the skin surface, the concentration of the drug accumulated in the skin and the amount of the drug eliminated into the blood vessel depend on the value of a parameter, r.
AB Gumel +9 more
core +3 more sources
FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
Temperature induced changes in the optical properties of skin in vivo
Scientific Reports, 2021 Knowledge of temperature-induced changes of skin optical properties is required for accurate dosimetry of photothermal treatments. We determined and compared in vivo optical properties of mouse ear skin at different temperatures. The diffuse reflectance,
Tyler W. Iorizzo +4 more
doaj +1 more source
, 2013 Method for determining the magnetic susceptibility in the high doped semiconductors is considered. A procedure that is based on double integration of the positive part of the derivative of the absorption line having a Dyson shape and takes into account ...
Goloshchapov, S. I. +4 more
core +1 more source
Hydroxychloroquine Associated With Lower Glomerular Filtration Rate Decline in Lupus Nephritis
Arthritis Care &Research, EarlyView.Objective Hydroxychloroquine (HCQ) protects kidney function in lupus nephritis (LN) by preventing flares, yet some cohort studies show no significant benefit in kidney function with HCQ. Clarifying these conflicting findings by showing early and long‐term benefits of HCQ on kidney function preservation is critical.
Shivani Garg +9 more
wiley +1 more source