Results 41 to 50 of about 495,232 (306)

Human skin absorption of three phthalates [PDF]

Toxicology Letters
Population studies reveal widespread exposure to phthalates. Understanding their absorption, distribution, metabolism, and excretion is vital to reduce exposure. However, data on skin absorption remain limited. We thus aim to characterize the skin permeation of three phthalates in a mixture, neat or in emulsion; di(2-ethylhexyl) phthalate (d4-DEHP ...
Hopf, N.B., De Luca, H.P., Borgatta, M., Koch, H.M., Pälmke, C., Benedetti, M., Berthet, A., Reale, E.   +7 more
openaire   +2 more sources

N-alkylamides : from plant to brain [PDF]

, 2014
Background: Plant N-alkylamides (NAAs) are bio-active compounds with a broad functional spectrum. In order to reach their pharmacodynamic targets, they have to overcome several barriers of the body in the absorption phase.
De Spiegeleer, Bart, Joshi, Tanmayee, Taevernier, Lien, Tatke, Pratima, Verbeke, Frederick, Veryser, Lieselotte, Wynendaele, Evelien   +6 more
core  

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Air, Skin, and Biological Monitoring of French Fire Instructors’ Exposure to Particles/PAHs During Controlled Fire and Mitigation Strategies

Toxics
Occupational exposure as a firefighter was recently classified as carcinogenic to humans by the IARC. Fire instructors’ exposure to carcinogenic PAHs is a major concern, and studies that have tried to assess the determinants of their exposure are scarce.
Pauline Zangl, Clément Collart, Renaud Persoons   +2 more
doaj   +1 more source

Temperature induced changes in the optical properties of skin in vivo

Scientific Reports, 2021
Knowledge of temperature-induced changes of skin optical properties is required for accurate dosimetry of photothermal treatments. We determined and compared in vivo optical properties of mouse ear skin at different temperatures. The diffuse reflectance,
Tyler W. Iorizzo, Peter R. Jermain, Elena Salomatina, Alona Muzikansky, Anna N. Yaroslavsky   +4 more
doaj   +1 more source

Giant microwave absorption in fine powders of superconductors [PDF]

, 2018
Enhanced microwave absorption, larger than that in the normal state, is observed in fine grains of type-II superconductors (MgB$_2$ and K$_3$C$_{60}$) for magnetic fields as small as a few $\%$ of the upper critical field.
Bud’ko, Sergey, Canfield, Paul, Canfield, Paul, Csősz, G., Jánossy, A., Kamarás, K., Klupp, G., Kogan, Vladimir, Murányi, F., Márkus, B., Nemes, N., Simon, F.   +11 more
core   +3 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Evaluation of the Percutaneous Absorption of Drug Molecules in Zebrafish

Molecules, 2020
In recent decades, zebrafish (Danio rerio) has become a widely used vertebrate animal model for studying development and human diseases. However, studies on skin medication using zebrafish are rare.
Daizo Morikane, Liqing Zang, Norihiro Nishimura   +2 more
doaj   +1 more source

Pharmacokinetics and the Dermal Absorption of Bromochlorophene, a Cosmetic Preservative Ingredient, in Rats

Toxics, 2022
The cosmetic industry has flourished in recent years. Accordingly, the safety of cosmetic ingredients is increasing. Bromochlorophene (BCP) is a commonly used cosmetic preservative.
Yong-Jae Lee, Hyang-Yeon Kim, Quynh-Lien Pham, Jung-Dae Lee, Kyu-Bong Kim   +4 more
doaj   +1 more source