Results 201 to 210 of about 641,694 (264)

Targeting PLD3 Reverses the Immunosuppressive Niche by Reprogramming Tumor‐Associated Macrophages and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
PLD3 activates the lysosomal‐AKT‐NF‐κB axis to drive cellular senescence in macrophages, establishing an immunosuppressive TME by limiting the infiltration of cytotoxic T, NK, and NKT cells, which confers resistance to anti‐PD‐1 therapy. Abrine inhibits PLD3 expression, restoring antitumor immunity and synergizing with anti‐PD‐1 treatment.
Xingtu Qin, Qiong Li, Xuemei Xu, Yuhan Wu, Yin Zhu, Jieqiong Wu, Yuan Fang, Qiubei Chen, Shuyang Wang, Jiang Yu, Yaping Ye, Hongli Jiao   +11 more
wiley   +1 more source

Author Correction: LZTR1 regulates epithelial MHC-I expression via NF-κB1 to modulate CD8+ T cells activation

Cell Discovery
Rundong Jiang, Zhiqin Fang, Yutong Wang, Bo Huang, Junkun Liu, Lam C. Tsoi, Rachael Bogle, Zongbo Zhang, Yehong Kuang, Xin Li, Liang Dong, Liping Jin, Johann E. Gudjonsson, Mingzhu Yin, Xiang Chen   +14 more
doaj   +1 more source

mTORC2 Phosphorylation of GSDME‐N Drives Cullin4B‐Mediated Proteasomal Degradation to Suppress Pyroptosis and Confer Radioresistance in Small Cell Lung Cancer

Advanced Science, EarlyView.
Radioresistance severely limits the efficacy of therapies for small cell lung cancer (SCLC). This study reveals a novel mechanism of resistance driven by the active suppression of pyroptosis. Specifically, the mTORC2 complex directly phosphorylates GSDME‐N and promotes its CUL4B‐mediated ubiquitination and proteasomal degradation.
Qing‐qing Xu, Ci‐ming Sun, Sui‐xian Zhang, Rui Li, Chen‐fei Wu, Zai‐shan Lin, Li Li, Run‐zhe Chen, Qi‐wen Li, Yuan‐yuan Chen, Xuan Li, Ming Chen   +11 more
wiley   +1 more source

Rates of Self-Reported Skin Cancer in Current and Retired Elite Australian Cricketers. [PDF]

Australas J Dermatol
Orchard JW, Redmayne G, Stenner B, Chamberlain AJ, Ming A, Inge P, Yip L.   +6 more
europepmc   +1 more source

Epiplakin expression in non-melanoma skin cancer: associations with epithelial-mesenchymal transition markers and tumor invasion. [PDF]

An Bras Dermatol
Fındık DG, Türelik Ö.
europepmc   +1 more source

The Epigenetic Landscape and Exposome of Non-Melanoma Skin Cancer: Mechanisms, Biomarkers, and Therapeutic Perspectives. [PDF]

Genes (Basel)
Albulescu A, Fudulu A, Constantin Iancu IV, Plesa A, Huica I, Botezatu A.   +5 more
europepmc   +1 more source

Hypergraph-based contrastive embedding and attention fusion for detection of skin cancer. [PDF]

Sci Rep
Banerjee T, Chhabra P, Kumar M, Kumar A, Abhishek K, Shafeeq BMA.   +5 more
europepmc   +1 more source

Multimodal models for skin cancer classification using clinical freetext and dermatoscopic images. [PDF]

Commun Med (Lond)
Watson M, Winterbottom T, Hudson T, Jones B, Shum HPH, Atapour-Abarghouei A, Breckon T, Harmsworth King J, Al Moubayed N.   +8 more
europepmc   +1 more source

Editorial: Genetics and epigenetics of melanoma and non-melanoma skin cancer. [PDF]

Front Genet
Moltrasio C, Tricarico PM, Suleman M, Crovella S, Romagnuolo M.   +4 more
europepmc   +1 more source