Results 41 to 50 of about 699,980 (314)
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Direct transdifferentiation of tumorigenic melanoma cells induces tumor cell reversion
Cell Death and DiseaseMelanoma is an aggressive skin cancer and highly lethal at advanced stages due to its high tumorigenicity and metastatic capacity. Changing the phenotype of cancer cells from one lineage to another, a process called transdifferentiation, leads to tumor ...
Yiman Wang +15 more
doaj +1 more source
Global controversies and advances in skin cancer
, 2013 Advances and controversies of skin cancer prevention in the Asian-Pacific region are to be examined in the world's first Global Controversies and Advances in Skin Cancer Conference to be held in Brisbane, Australia this November.
Dunn, Jeff, Baldwin, Louise
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FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
BMC Cancer, 2019 Background BRCA1 associated-protein 1 (BAP1) tumor predisposition syndrome is associated with an increased risk for malignant mesotheliomas, uveal and cutaneous melanomas, renal cell carcinomas, and singular cutaneous lesions.
Bianca Costa Soares de Sá +8 more
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Cells, 2021 New therapeutic strategies are needed for cutaneous T-cell lymphoma (CTCL), and the plant extract ingenol mebutate (PEP005) may be considered. PEP005 has been approved for actinic keratosis, and proapoptotic activities were described in different cancer ...
Uly Sumarni +2 more
doaj +1 more source
Etiology of Nonmelanocytic Skin Cancer
, 2007 Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas, U.S.A. INTRODUCTION The incidence of skin cancer is rapidly rising with an occurrence of 1.2 million new cases each year in the United States alone (1) and 1% to
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Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Selective anticancer activity of a hexapeptide with sequence homology to a non-kinase domain of Cyclin Dependent Kinase 4 [PDF]
, 2011 Background: cyclin-dependent kinases 2, 4 and 6 (Cdk2, Cdk4, Cdk6) are closely structurally homologous proteins which are classically understood to control the transition from the G1 to the S-phases of the cell cycle by combining with their appropriate ...
Maurer, RI +28 more
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