Results 31 to 40 of about 1,233,961 (300)
Sirtuins in Skin and Skin Cancers [PDF]
Skin Pharmacology and Physiology, 2017 The sirtuins are a family of proteins that comprise class III of the histone deacetylases. These NAD+-dependent proteins have been found to be intricately involved in a variety of important and skin-relevant cellular functions and processes, including aging, UV damage response, oxidative stress, and wound repair.
Liz Mariely, Garcia-Peterson +5 more
openaire +2 more sources
SOX2 and cancer: current research and its implications in the clinic
Clinical and Translational Medicine, 2014 SOX2 is a gene that encodes for a transcription factor belonging to the SOX gene family and contains a high‐mobility group (HMG) domain, which permits highly specific DNA binding.
Kasia Weina, Jochen Utikal
doaj +1 more source
Toxic Epidermal Necrolysis after Pemetrexed and Cisplatin for Non-Small Cell Lung Cancer in a Patient with Sharp Syndrome [PDF]
, 2012 Background: Pemetrexed is an antifolate drug approved for maintenance and second-line therapy, and, in combination with cisplatin, for first-line treatment of advanced nonsquamous non-small cell lung cancer.
Aguiar D +28 more
core +1 more source
Journal for ImmunoTherapy of Cancer, 2018 Background Paraneoplastic hyperleucocytosis (PH) is sporadically seen in patients with advanced solid tumors. Case presentation We report a female patient with disseminated melanoma metastases.
Thilo Gambichler +2 more
doaj +1 more source
Management of skin-sparing mastectomy: Results of a survey of German Hospitals [PDF]
, 2006 Background: The aim of this study was to evaluate the current management of skin-sparing mastectomy in German hospitals and to determine its oncologic safety.
Dian, D. +4 more
core +1 more source
Melanoma-Derived iPCCs Show Differential Tumorigenicity and Therapy Response
Stem Cell Reports, 2017 A point mutation in the BRAF gene, leading to a constitutively active form of the protein, is present in 45%–60% of patients and acts as a key driver in melanoma.
Mathias Bernhardt +11 more
doaj +1 more source
Skin involvement as the presenting sign of a male breast cancer [PDF]
, 2020 Male breast cancer is a rare disease with an unknown etiopathogenesis.
Alouani, Imane +4 more
core
Pediatric Blood &Cancer, EarlyView.ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács +8 more
wiley +1 more source
Promoting Skin Cancer Awareness [PDF]
, 2017 Skin cancer is the most common cancer in the nation and the cost to treat it is around 8 billion dollars a year. Sun exposure is linked to all three types of skin cancer and incidence of melanoma is highest in Caucasians compared to other races.
Kolli, Sree Sahithi
core +1 more source