Results 11 to 20 of about 641,694 (264)

The UQ Flap: A Novel Modification of the Keystone Flap

Plastic and Reconstructive Surgery, Global Open, 2022
Summary:. Wound closure following excisions on the leg (between the knee and ankle), including the distal leg, is challenged by limited skin laxity. The keystone flap, first described by Behan in 2003, was proposed as one solution, but with a significant
Mohammadreza Hassani, MD, MMed (Skin Cancer), Isolde Hertess, BSc, MBBS, FRACS (Plastics and Reconstructive), Simon Tucker, MBChB, FRCP(UK), FACD, Martelle Coetzer-Botha, MBChB, MMed (Skin Cancer), Harald Kittler, MD, Cliff Rosendahl, MBBS, PhD   +5 more
doaj   +1 more source

Tumor microenvironment-derived S100A8/A9 is a novel prognostic biomarker for advanced melanoma patients and during immunotherapy with anti-PD-1 antibodies

Journal for ImmunoTherapy of Cancer, 2019
Background Predicting metastasis in melanoma patients is important for disease management and could help to identify those who might benefit from adjuvant treatment.
Nikolaus B. Wagner, Benjamin Weide, Mirko Gries, Maike Reith, Kathrin Tarnanidis, Valerie Schuermans, Charlotte Kemper, Coretta Kehrel, Anne Funder, Ramtin Lichtenberger, Antje Sucker, Esther Herpel, Tim Holland-Letz, Dirk Schadendorf, Claus Garbe, Viktor Umansky, Jochen Utikal, Christoffer Gebhardt   +17 more
doaj   +1 more source

Patients with melanoma of unknown primary show better outcome under immune checkpoint inhibitor therapy than patients with known primary: preliminary results

OncoImmunology, 2019
Background: Melanoma of unknown primary (MUP) is an uncommon clinical subtype of melanoma of known primary (MKP). Objectives: We aimed to compare treatment outcomes of MUP and MKP patients who had undergone therapy with immune checkpoint inhibitors (ICPI)
Thilo Gambichler, Maria Chatzipantazi, Ulrike Schröter, E. Stockfleth, Cansu Gedik   +4 more
doaj   +1 more source

Primary breast parenchyma melanoma: case report

Brazilian Journal of Oncology, 2021
Introduction: Primary breast melanoma is a rare condition and most of cases are associated with melanoma overlying the skin of the breast or metastatic disease site.
Eduardo Doria, Gion Aléssio Rocha Brunn, Diego Noya Brandão, Rafael Silva Ribeiro, Adriano Mata Pires Freire Carvalho, Miguel Ângelo Brandrão   +5 more
doaj   +1 more source

The Role of Myeloid-Derived Suppressor Cells (MDSC) in Cancer Progression

Vaccines, 2016
The immunosuppressive tumor microenvironment represents not only one of the key factors stimulating tumor progression but also a strong obstacle for efficient tumor immunotherapy.
Viktor Umansky, Carolin Blattner, Christoffer Gebhardt, Jochen Utikal   +3 more
doaj   +1 more source

BET inhibitors synergize with sunitinib in melanoma through GDF15 suppression

Experimental and Molecular Medicine, 2023
Cancer: a drug combination for combating melanoma Drugs that target proteins involved in issuing stop and start commands to cancer-related genes help to sensitize melanoma cells to a widely used anti-cancer therapy, leading to tumor shrinkage in mice ...
Furong Zeng, Yayun Li, Yu Meng, Huiyan Sun, Yi He, Mingzhu Yin, Xiang Chen, Guangtong Deng   +7 more
doaj   +1 more source

Enrichment of Human Dermal Stem Cells from Primary Cell Cultures through the Elimination of Fibroblasts

Cells, 2023
Dermal stem cells (DSCs), which are progenitor cells of melanocytes, are isolated from human foreskin and cultivated as mixed cultures containing both DSCs and fibroblasts in varying proportions.
Christin Starzonek, Mouna Mhamdi-Ghodbani, Stefan Henning, Marc Bender, Sarah Degenhardt, I-Peng Chen, Mohamed Said, Rüdiger Greinert, Beate Volkmer   +8 more
doaj   +1 more source

Clinical, dermoscopic and histopathologic findings of retiform hemangioendothelioma

Dermatology Practical & Conceptual, 2013
Retiform hemangioendothelioma (RH) is an uncommon vascular neoplasm of borderline malignancy that clinically develops as a solitary, gradually enlarging exophytic mass, nodule or plaque, most often on the lower limbs, upper limbs and trunk.
Amanda Mota, Giuseppe Argenziano, Iris Zalaudek, Simonetta Piana, Caterina Longo, Elvira Moscarella, Aimilios Lallas   +6 more
doaj   +1 more source

Sirtuins in Skin and Skin Cancers [PDF]

Skin Pharmacology and Physiology, 2017
The sirtuins are a family of proteins that comprise class III of the histone deacetylases. These NAD+-dependent proteins have been found to be intricately involved in a variety of important and skin-relevant cellular functions and processes, including aging, UV damage response, oxidative stress, and wound repair.
Liz Mariely, Garcia-Peterson, Melissa Jean, Wilking-Busch, Mary Ann, Ndiaye, Christine Gaby Azer, Philippe, Vijayasaradhi, Setaluri, Nihal, Ahmad   +5 more
openaire   +2 more sources

Mitochondrial Sirtuins in Skin and Skin Cancers [PDF]

Photochemistry and Photobiology, 2020
AbstractMammalian sirtuins (SIRTs 1‐7) are a family of NAD+‐dependent deacetylases with distinct subcellular localization and biological functions that regulate various important cellular processes. Among these, SIRTs ‐3, ‐4 and ‐5 are located in the mitochondria and have been implicated in caloric restriction, oxidative stress, aging and various human
Shengqin Su, Mary Ndiaye, Chandra K. Singh, Nihal Ahmad   +3 more
openaire   +2 more sources