Results 91 to 100 of about 1,486,496 (365)
Molecular Oncology, EarlyView.This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini +10 more
wiley +1 more source
Estimating Skin Tone and Effects on Classification Performance in Dermatology Datasets [PDF]
arXiv, 2019 Recent advances in computer vision and deep learning have led to breakthroughs in the development of automated skin image analysis. In particular, skin cancer classification models have achieved performance higher than trained expert dermatologists. However, no attempt has been made to evaluate the consistency in performance of machine learning models ...
arxiv
Genital Skin Diseases and Their Expression in Sexual Functionality [PDF]
, 2015 Sexual functionality acts as an important function of the individual, acting both physically and mentally to create a state of well-being and permitting procreation.
Albu, Gabriela +3 more
core +2 more sources
Tetracycline Actions Relevant to Rosacea Treatment [PDF]
, 2009 Until today, the pathogenesis of rosacea is not known in detail. Yet in recent years evidence has been accumulating that rosacea with its common symptoms such as inflammatory lesions, erythema, telangiectasia, phymatous changes, and ocular symptoms is of
Korting, Hans Christian, Schöllmann, C.
core +1 more source
Germline variants in CDKN2A wild‐type melanoma prone families
Molecular Oncology, EarlyView.Among melanoma‐prone families, wild‐type for CDKN2A and CDK4, some have pathogenic variants in genes not usually linked to melanoma. Furthermore, rare XP‐related variants and variants in MC1R are enriched in such families. Germline pathogenic variants in CDKN2A are well established as an underlying cause of familial malignant melanoma. While pathogenic
Gjertrud T. Iversen +5 more
wiley +1 more source
Drugs in R&DBackground and Objective Adult-onset Still’s disease (AOSD) is a recognized autoinflammatory disorder of unknown etiology. The standard initial management for AOSD includes conventional corticosteroids and disease-modifying antirheumatic drugs.
Li Tang +5 more
doaj +1 more source
Crohn’s disease and skin [PDF]
United European Gastroenterology Journal, 2016 Crohn’s disease is a chronic inflammatory bowel disease potentially involving any segment of the gastrointestinal tract. Extra‐intestinal manifestations may occur in 6%–40% of patients, and disorders of the skin are among the most common. This manuscript will review skin manifestations associated to Crohn’s disease, with a particular focus on lesions ...
Gravina, AG +10 more
openaire +4 more sources
Sistem Pakar Diagnosis Penyakit Kulit pada Kucing Menggunakan Metode Certainty Factor [PDF]
, 2014 Skin disease is a type of diseases that frequently infects pets especially cat. Cat that is infected the skin diseases, may initially looked fine. Based on interview with veterinarian who specializes in dogs and cats diseases, skin evaluation to the pets
Jusak, J. (Jusak) +2 more
core
Molecular Oncology, EarlyView.Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu +11 more
wiley +1 more source