Results 101 to 110 of about 1,486,496 (365)

JAK3 as an emerging target for topical treatment of inflammatory skin diseases [PDF]

, 2016
The recent interest and elucidation of the JAK/STAT signaling pathway created new targets for the treatment of inflammatory skin diseases (ISDs). JAK inhibitors in oral and topical formulations have shown beneficial results in psoriasis and alopecia ...
Alves de Medeiros, Ana, De Schepper, Sofie, Desmet, Eline, Lambert, Jo, Speeckaert, Reinhart, Van Gele, Mireille   +5 more
core   +6 more sources

DERMATOSCOPY AS A METHOD OF EVALUATING THE EFFICIENCY OF 5% CREAM IMYKVIMOD IN PATIENTS WITH BASAL CELL CARCINOMA OF SKIN

Vestnik Dermatologii i Venerologii, 2017
The aim. investigation of the possibilities of dermatoscopy as a method for evaluating the effectiveness of therapy with topical imiquimod in patients with superficial basal cell carcinoma (CCB). Materials and methods. the study included 24 patients with
M. V. Zhuchkov, D. B. Sonin, M. A.  Tarasova, S. A. Kosorukova   +3 more
doaj   +1 more source

Occupational Skin Disease [PDF]

Postgraduate Medical Journal, 1989
It is opportune to discuss occupational skin disorders since recently a 'Save your Skin' Campaign has been undertaken in the United Kingdom by the Employment Advisory Service of the Health and Safety Executive to increase the awareness of employers and employees of the need to prevent skin problems in industry.' This was justified because skin ...
openaire   +4 more sources

Mouse genetics identifies unique and overlapping functions of fibroblast growth factor receptors in keratinocytes [PDF]

, 2020
Fibroblast growth factors (FGFs) are key regulators of tissue development, homeostasis and repair, and abnormal FGF signalling is associated with various human diseases.
Ben-Yehuda Greenwald, Maya, Chen, Lin, Iizuka, Haruka, Jukic, Marko, Kubo, Fumimasa, Meyer, Michael, Ornitz, David M, Rauschendorfer, Theresa, Sänger, Catharina, Werner, Sabine   +9 more
core   +2 more sources

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Gasdermin E promotes translocation of p65 and c-jun into nucleus in keratinocytes for progression of psoriatic skin inflammation

Cell Death and Disease
Gasdermin E (GSDME) has recently been identified as a critical executioner to mediate pyroptosis. While epidermal keratinocytes can initiate GSDME-mediated pyroptosis, the role of keratinocyte GSDME in psoriatic dermatitis remains poorly characterized ...
Fangyuan Long, Xuecui Wei, Yujie Chen, Min Li, Ni Lian, Shanshan Yu, Sihan Chen, Yong Yang, Min Li, Heng Gu, Xu Chen   +10 more
doaj   +1 more source

DISEASES OF THE SKIN. [PDF]

The Lancet
n ...
openaire   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Infectious Skin Diseases in Children in General Practice: epidemiology and management [PDF]

, 2007
The increasing proportion of skin diseases, especially infectious and allergic skin diseases, encountered in general practice represents a substantial part of the morbidity in children.
Mohammedamin, R.S.A. (Robbert)
core   +2 more sources

APPLICATION OF THE K-MEANS ALGORITHM IN IDENTIFYING TYPES OF SKIN DISEASE1 [PDF]

, 2021
In the process of grouping the types of skin diseases, doctors and hospital staff encountered various obstacles, including difficulties in grouping data on types of skin diseases.
Hasan Putra, Purwa
core   +1 more source