Results 41 to 50 of about 759,657 (212)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

In Silico Approaches and the Role of Ontologies in Aging Research [PDF]

, 2013
The 2013 Rostock Symposium on Systems Biology and Bioinformatics in Aging Research was again dedicated to dissecting the aging process using in silico means.
Busch, Hauke, Börries, Melanie, de Grey, Aubrey, Fuellen, Georg, Hahn, Udo, Hiller, Thomas, Hoeflich, Andreas, Jansen, Ludger, Janssens, Georges E., Kaleta, Christoph, Meinema, Anne C., Others, Schofield, Paul N., Schäuble, Sascha, Smith, Barry   +14 more
core  

The novel MAPT mutation K298E:mechanisms of mutant tau toxicity, brain pathology and tau expression in induced fibroblast-derived neurons [PDF]

, 2013
Frontotemporal lobar degeneration (FTLD) consists of a group of neurodegenerative diseases characterized by behavioural and executive impairment, language disorders and motor dysfunction.
Calo, Laura, Goedert, Michel, Holton, Janice L., Iovino, Mariangela, Lashley, Tammaryn, Lund University., Lund University., Lund University., Muqit, Miratul M. K., Parmar, Malin,, Pfisterer, Ulrich,, Revesz, Tamas, Spillantini, Maria Grazia, Swingler, Robert J., Treacy, Rebecca   +14 more
core   +4 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Invited review: Camel skin diseases survey in Morocco [PDF]

, 2019
The present study aimed to collect data related to skin diseases in dromedary camels in the south of Morocco. As a whole, 168 herds from 9 provinces located in the south of Morocco have been prospected.
Bengoumi, Mohammed, Faye, Bernard, Kamili, Asma, Tligui, Nour Said   +3 more
core  

Antimicrobial peptides: agents of border protection for companion animals. [PDF]

, 2012
Over the past 20 years, there have been significant inroads into understanding the roles of antimicrobial peptides in homeostatic functions and their involvement in disease pathogenesis.
Affolter, Verena K, Bevins, Charles L, Leonard, Brian C   +2 more
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Antimicrobial Peptides and Skin: A Paradigm of Translational Medicine [PDF]

, 2012
Antimicrobial peptides (AMPs) are small, cationic, amphiphilic peptides with broad-spectrum microbicidal activity against both bacteria and fungi. In mammals, AMPs form the first line of host defense against infections and generally play an important ...
Albiol Matanic VC, Bayerl C, Berg M, Blount BW, Boguniewicz M, Bourinbaiar AS, Bradshaw J, Brogden NK, Brown JM, Carretero M, Christophers E, Ciornei CD, Conner K, Cork MJ, de Jongh GJ, Degitz K, Dempsey CE, Dubos RJ, Eiseman AS, Epand RF, Erdag G, Escher N, Falagas ME, Ge Y, Giacometti A, Glaser R, Gläser R, Gregory SM, Grossgebauer K, Guarna M, Guiliani A, Guttman-Yassky E, Hancock RE, Harder J, Harder J, Harder J, Hartmann D, Howell MD, Huttner KM, Imura Y, Jacob L, Jacobsen F, Jung K, Khandelia H, Koch-Weser J, Koczulla R, Korting HC, Kotlan B, Kretschmar M, Kretschmar M, Kretschmar M, Kreuter A, Kruse T, Lai Y, Lai YP, Lande R, Li Q, Lind HE, Liu AY, Madsen P, Mallow EB, Marincola FM, Maroti G, Melo MN, Mogi T, Muramatsu I, Nagy I, Nijnik A, Nomura I, Nussenblatt RB, Ong PY, Oono T, Pivarcsi A, Plebani M, Reddy KVR, Reddy KVR, Rieg S, Risso A, Ruckdeschel G, Rudolph B, Sader HS, Schauber J, Schauber J, Schittek B, Schittek B, Schneider JJ, Schröder JM, Schön MP, Seoh SA, Shai Y, Sigurdadottir T, Simmaco M, Steinstraesser L, Steinstraesser L, Steinstraesser L, Storm DR, Svinarich DM, Tang YQ, Voigt HU, Wang G, Wang Z, Willenberg W, Yamasaki K, Yamasaki K, Zairi A, Zanger P, Zasloff M   +106 more
core   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source