Results 151 to 160 of about 350,458 (294)

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

Advanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang, Na Li, Yan Wang, Jing Zhang, Jiahui Liu, Lei Chen, Yongdong Song, Yurong Mu, Yuechen Han, Yafeng Lyu, Xiaofei Li, Hanyue Wang, Jing Wang, Yao Lu, Zhaomin Fan, Daogong Zhang, Haibo Wang   +16 more
wiley   +1 more source

Questions and answers about skin cancer prevention

Studies show that even a few serious sunburns can increase your risk of getting skin cancer in the future. Fortunately, skin cancer is one of the most preventable cancers.

core  

Cancer: Mass Media for Skin Cancer

The Community Preventive Services Task Force (CPSTF) findings and recommendations for "Preventing Skin Cancer: Mass Media" are based on systematic reviews of evidence of effectiveness and economic impact.

core   +1 more source

Clinical Evaluation <i>Versus</i> Clinical Evaluation With Dermoscopy in Malignant Skin Neoplasms Diagnosis. [PDF]

In Vivo
Majewska O, Kulig P, Brzewski P, Kulig J, Markiewicz A.   +4 more
europepmc   +1 more source

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

Model for Detecting Globules in Images of Skin Neoplasms

: This article is devoted to the digital processing of images of skin neoplasms to detect significant structural elements in the diagnosis of melanoma–globules (clumps, lumps).
Lim A.O., Nikitaev V.G., Kozlov V.S., Pronichev A.N., Tamrazova O.B., Sergeev V.Y.   +5 more
core   +1 more source

Occupational Sun Exposure and Skin Neoplasms in a Dermatology Referral Service in Southeast Brazil: A Cross-Sectional Study. [PDF]

Cureus
Augusto Cardozo ME, Ferreira FR, Ferreira da Silva M, Guedes Dos Santos P, de Jesus Pereira de Andrade J.   +4 more
europepmc   +1 more source

Fibronectin1‐Expressing Subicular Circuits Selectively Govern the Retrieval of Novel Object Recognition

Advanced Science, EarlyView.
Fibronectin 1 (FN1)‐expressing subicular subpopulations encode novel object preference and selectively govern retrieval of novel object recognition (NOR) via affecting excitability of entorhinal‐projecting circuit through large conductance Ca2+‐activated potassium (BK) channel. ABSTRACT Novel object recognition (NOR), referring to the cognitive ability
Fan Fei, Jiaying Shi, Jing Xi, Yixiang Xu, Shuye Ying, Xukun Fan, Wangjialu Lu, Zhisheng Li, Menghan Li, Yu Wang, Li Cheng, Lin Yang, Lingyu Xu, Zhong Chen, Cenglin Xu, Yi Wang   +15 more
wiley   +1 more source

Targeting Skin Neoplasms: A Review of Berberine's Anticancer Properties. [PDF]

Cells
Duda-Madej A, Lipska P, Viscardi S, Bazan H, Sobieraj J.   +4 more
europepmc   +1 more source

Multiple Skin Neoplasms at One Site (MUSK IN A NEST): A Comprehensive Review of Basal Cell Carcinoma and Benign or Malignant "Collision" Tumors at the Same Cutaneous Location. [PDF]

Clin Cosmet Investig Dermatol, 2020
Cohen PR, Calame A.
europepmc   +1 more source