Results 161 to 170 of about 350,458 (294)

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

Model for Estimating the Morphological Characteristics of Structureless Areas of Pigmented Skin Neoplasms

The problem of early diagnosis of skin melanoma by dermatoscopic images of skin neoplasms is considered. A model for assessing the diagnostically significant morphological characteristics of neoplasm elements—structureless areas—is proposed.
Sergeev V.Yu., Lim A.O., Nikitaev V.G., Kozlov V.S., Pronichev A.N., Tamrazova O.B., Sergeev Yu.Yu.   +6 more
core   +1 more source

Disentangling the genetic relationship between malignant skin neoplasms and sepsis: Evidence from bidirectional Mendelian randomization. [PDF]

Medicine (Baltimore)
Liu Q, Jia W, Xia D, Yang L, Gu D.
europepmc   +1 more source

[Skin neoplasms].

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1974
G, Rajka, O H, Iversen
openaire   +3 more sources

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Everyone can play a role to reduce skin cancer [PDF]

Poster The Surgeon General\u2019s call to action to prevent skin ...

core  

A Model for Recognition of Dermatoscopic Points in Images of Skin Neoplasms

The challenges of using computer diagnostics to seek structural elements of melanocytic neoplasms, including cutaneous melanomas at early stages of their development, are discussed.
Solomatin M.A., Nikitaev V.G., Kozlov V.S., Pronichev A.N., Tamrazova O.B., Kruglova L.S., Sergeev V.Y., Druzhinina E.A.   +7 more
core   +1 more source

Multi-Wavelength Raman Differentiation of Malignant Skin Neoplasms. [PDF]

Int J Mol Sci
Rimskaya E, Gorevoy A, Shelygina S, Perevedentseva E, Timurzieva A, Saraeva I, Melnik N, Kudryashov S, Kuchmizhak A.   +8 more
europepmc   +1 more source

Solid Harmonic Wavelet Bispectrum for Image Analysis

Advanced Science, EarlyView.
The Solid Harmonic Wavelet Bispectrum (SHWB), a rotation‐ and translation‐invariant descriptor that captures higher‐order (phase) correlations in signals, is introduced. Combining wavelet scattering, bispectral analysis, and group theory, SHWB achieves interpretable, data‐efficient representations and demonstrates competitive performance across texture,
Alex Brown, Mathilda Avirett‐Mackenzie, Carolin Villforth, Georgios Exarchakis   +3 more
wiley   +1 more source

Immunological Landscape of Non-Melanoma Skin Neoplasms: Role of CTLA4+IFN-γ+ Lymphocytes in Tumor Microenvironment Suppression. [PDF]

Medicina (Kaunas)
Karabatić Knezović S, Knezović D, Ban J, Matana A, Puizina Ivić N, Glavina Durdov M, Merćep M, Drmić Hofman I.   +7 more
europepmc   +1 more source