Results 111 to 120 of about 948,428 (252)
Advanced Science, EarlyView.This study reveals that long non‐coding RNAs represent important regulatory components underlying pear domestication and improvement. Integrative multi‐omics analyses identify selected lncRNAs associated with fruit traits, while functional validation uncovers a lignin‐related lncRNA, lncRNA‐pys, that promotes lignin accumulation.
Bobo Song +9 more
wiley +1 more source
Transdermal Drug Delivery Systems: Methods for Enhancing Skin Permeability and Their Evaluation
PharmaceuticsTransdermal drug delivery (TDD) is an increasingly important non-invasive method for administering active pharmaceutical ingredients (APIs) through the skin barrier, offering advantages such as improved therapeutic efficacy and reduced systemic side ...
Elena O. Bakhrushina +10 more
doaj +1 more source
Novel insights into ascorbic acid skin permeation [PDF]
Ascorbic acid (vitamin C) is a popular topically applied cosmeceutical due to its antioxidative, photoprotective, antiaging and antipigmentary effects.
Mistry, Jatin
core
, 2019 The present study aimed to evaluate the penetration activity of O-acylterpineol derivatives both in vitro and in vivo, and to investigate the enhancing mechanism of O-acylterpineol derivatives which were synthesized by α-terpineol and fatty acid.
Chunyan Wang (306606) +5 more
core +1 more source
Printable Piezoresistive Hybrid Hydrogels Based on 2D MoS2 for Flexible Pulse Sensing
Advanced Science, EarlyView.Hybrid 1T‐MoS2‐based hydrogels are engineered through UV curing and 3D printing to achieve tunable electromechanical properties for wearable sensing. These soft architectures enhance mechanical stability and reproducible piezoresistive responses within the physiological pressure range.
Jenny Flores +18 more
wiley +1 more source
Increased Skin Permeation of Acyclovir by Incorporation into Chitosan-Tripolyphosphate Nanoparticles
, 2009 Purpose: To create a skin delivery system based on chitosan-tripolyphosphate nanoparticles (cs-tpp np) for acyclovir with enhanced chemical stability and satisfying permeation through ...
A. HASANOVIC
core +1 more source
Advanced Science, EarlyView.In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao +12 more
wiley +1 more source
Suitability of skin-PAMPA and chromatographic systems to emulate skin permeation. Influence of pH on skin-PAMPA permeability [PDF]
The skin permeation, Kp, of a chemical compound is a relevant parameter in fields such as toxicology, exposure to pollutants, or dermal studies of pharmaceutical and cosmetic interest.
Soriano-Meseguer, Sara +3 more
core +1 more source
Advanced Science, EarlyView.A root‐inspired microneedle array patch uses lattice‐based mechanical interlocking to unite rigid microneedles with a flexible substrate. The interlocked rigid–soft architecture improves interfacial bonding, supports stable adhesion on curved and wet tissues under dynamic motion, and provides a versatile platform for robust biointerfacing and future ...
Jongchan Lee +9 more
wiley +1 more source
, 1992 The iontophoretic transport properties of sodium cromoglycate were characterized using a synthetic membrane and excised hairless mouse skin. The permeation rate of sodium cromoglycate through the synthetic membrane was found to be linearly dependent on ...
L C Li, L V Allen, N T Vu
core +1 more source