Application of an Antioxidant Response Element–Nuclear Factor Erythroid 2 Luciferase Assay for Assessing the Skin Sensitization Potential of Agrochemicals [PDF]
Toxics, 2023 The skin sensitization potential of agrochemicals can be assessed using laboratory methods such as the keratinocyte activation assay so that their use in regulatory toxicology might replace experimental animal testing.
Ji-Yeon Yang +6 more
doaj +2 more sources
New Horizons in Skin Sensitization Assessment of Complex Mixtures: The Use of New Approach Methodologies Beyond Regulatory Approaches [PDF]
ToxicsSkin sensitization is a complex biological process induced by a wide range of chemicals, from single molecules to complex mixtures and finished products.
Argel Islas-Robles +3 more
doaj +2 more sources
Alternative Methods for Skin-Sensitization Assessment [PDF]
Toxics, 2022 Skin sensitization is a term used to refer to the regulatory hazard known as allergic contact dermatitis (ACD) in humans or contact hypersensitivity in rodents, an important health endpoint considered in chemical hazard and risk assessments.
Dominika Gądarowska +3 more
doaj +2 more sources
Antimicrobial Peptide Sublancin Skin Sensitization and Irritation Assessment in Guinea Pigs and Rabbits [PDF]
ToxicsThis study evaluated the skin sensitization of the antimicrobial peptide sublancin to support its safety assessment for topical application. Sensitization was assessed using the guinea pig maximization test (GPMT), in which animals received sublancin (2 ...
Yong Guo +5 more
doaj +2 more sources
Observation of hapten-induced sensitization responses for the development of a mouse skin sensitization test, including the elicitation phase [PDF]
Scientific Reports, 2022 The only official method that can detect the skin sensitizing potential of chemicals, including the elicitation response, is the OECD test guideline (TG) 406. However, this guideline uses guinea pigs, which requires complex procedures. Since a simple and
Ryo Kamata +5 more
doaj +2 more sources
Models of Dendritic Cells to Assess Skin Sensitization [PDF]
Frontiers in Toxicology, 2022 Allergic contact dermatitis (ACD) is a complex skin pathology occurring in reaction against environmental substances found in the workplace (cement, hair dyes, textile dyes), in the private environment (e.g., household products, cosmetic ingredients), or
Kévin Hardonnière +4 more
doaj +2 more sources
A Novel Machine Learning Model and a Web Portal for Predicting the Human Skin Sensitization Effects of Chemical Agents [PDF]
ToxicsSkin sensitization is a significant concern for chemical safety assessments. Traditional animal assays often fail to predict human responses accurately, and ethical constraints limit the collection of human data, necessitating a need for reliable in ...
Ricardo Scheufen Tieghi +8 more
doaj +2 more sources
An Integrated Testing Strategy and Online Tool for Assessing Skin Sensitization of Agrochemical Formulations [PDF]
ToxicsNon-animal assessment of skin sensitization is a global trend. Recently, scientific efforts have been focused on the integration of multiple evidence for decision making with the publication of OECD Guideline No.
Hung-Lin Kan +5 more
doaj +2 more sources
Updating Reaction Mechanistic Domains for Skin Sensitization: 1. Nucleophilic Skin Sensitizers. [PDF]
Chem Res ToxicolIt has long been recognized that skin sensitizers either are electrophilic or can be activated to electrophilic species. Several nonanimal assays for skin sensitization are based on this premise. In the course of a project to update dermal sensitization thresholds (DST), we found a substantial number of sensitizers, with no electrophilic or pro ...
Roberts DW +4 more
europepmc +3 more sources
A Human Skin Explant Test as a Novel In Vitro Assay for the Detection of Skin Sensitization to Aggregated Monoclonal Antibodies [PDF]
ToxicsIntroduction: Monoclonal antibodies (mAbs) are important therapeutics. However, the enhanced potential for aggregation has become a critical quality parameter during the production of mAbs. Furthermore, mAb aggregation may also present a potential health
Ana Martins-Ribeiro +6 more
doaj +2 more sources