Alternative Methods for Skin-Sensitization Assessment. [PDF]
Toxics, 2022 Skin sensitization is a term used to refer to the regulatory hazard known as allergic contact dermatitis (ACD) in humans or contact hypersensitivity in rodents, an important health endpoint considered in chemical hazard and risk assessments.
Gądarowska D +3 more
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Antimicrobial Peptide Sublancin Skin Sensitization and Irritation Assessment in Guinea Pigs and Rabbits. [PDF]
ToxicsThis study evaluated the skin sensitization of the antimicrobial peptide sublancin to support its safety assessment for topical application. Sensitization was assessed using the guinea pig maximization test (GPMT), in which animals received sublancin (2 ...
Guo Y +5 more
europepmc +3 more sources
Skin Sensitization Evaluation of Carbon-Based Graphene Nanoplatelets
Toxics, 2021 Graphene nanoplatelets (GNPs) are one of the major types of carbon based nanomaterials that have different industrial and biomedical applications. There is a risk of exposure to GNP material in individuals involved in their large-scale production and in ...
Sung-Hyun Kim +9 more
doaj +2 more sources
New Horizons in Skin Sensitization Assessment of Complex Mixtures: The Use of New Approach Methodologies Beyond Regulatory Approaches. [PDF]
ToxicsSkin sensitization is a complex biological process induced by a wide range of chemicals, from single molecules to complex mixtures and finished products.
Islas-Robles A +3 more
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Application of an Antioxidant Response Element-Nuclear Factor Erythroid 2 Luciferase Assay for Assessing the Skin Sensitization Potential of Agrochemicals. [PDF]
Toxics, 2023 The skin sensitization potential of agrochemicals can be assessed using laboratory methods such as the keratinocyte activation assay so that their use in regulatory toxicology might replace experimental animal testing.
Yang JY +6 more
europepmc +2 more sources
Models of Dendritic Cells to Assess Skin Sensitization. [PDF]
Front Toxicol, 2022 Allergic contact dermatitis (ACD) is a complex skin pathology occurring in reaction against environmental substances found in the workplace (cement, hair dyes, textile dyes), in the private environment (e.g., household products, cosmetic ingredients), or
Hardonnière K +4 more
europepmc +2 more sources
A Novel Machine Learning Model and a Web Portal for Predicting the Human Skin Sensitization Effects of Chemical Agents. [PDF]
ToxicsSkin sensitization is a significant concern for chemical safety assessments. Traditional animal assays often fail to predict human responses accurately, and ethical constraints limit the collection of human data, necessitating a need for reliable in ...
Scheufen Tieghi R +8 more
europepmc +2 more sources
An Integrated Testing Strategy and Online Tool for Assessing Skin Sensitization of Agrochemical Formulations. [PDF]
ToxicsNon-animal assessment of skin sensitization is a global trend. Recently, scientific efforts have been focused on the integration of multiple evidence for decision making with the publication of OECD Guideline No.
Kan HL +5 more
europepmc +2 more sources
A comprehensive review of the Direct Peptide Reactivity Assay in skin sensitization testing: Applicability, limitations, and considerations [PDF]
Arhiv za farmacijuSkin sensitization is a crucial endpoint in the safety assessment of chemicals, with the Direct Peptide Reactivity Assay (DPRA) emerging as a valuable in chemico method for evaluating a substance's sensitization potential.
Omeragić Elma +4 more
doaj +3 more sources
A Human Skin Explant Test as a Novel In Vitro Assay for the Detection of Skin Sensitization to Aggregated Monoclonal Antibodies. [PDF]
ToxicsIntroduction: Monoclonal antibodies (mAbs) are important therapeutics. However, the enhanced potential for aggregation has become a critical quality parameter during the production of mAbs. Furthermore, mAb aggregation may also present a potential health
Martins-Ribeiro A +6 more
europepmc +2 more sources