Results 91 to 100 of about 16,012,863 (396)

The IFNγ‐CIITA‐MHC II axis modulates melanoma cell susceptibility to NK‐cell‐mediated cytotoxicity

Molecular Oncology, EarlyView.
Natural killer (NK) cells play a central role in anti‐melanoma immunity. However, melanoma cells adapt during co‐culture by upregulating CIITA and MHC II in response to interferon gamma (IFNγ), thereby evading NK‐cell lysis. Blocking IFNγ signaling or treatment with dimethyl fumarate/simvastatin counteracts this immune escape and maintains NK‐cell ...
Lena C. M. Krause, Rixa‐Mareike Köhn, Christian Ickes, Julia Lenger, Jonas Fischer, Sabrina Cappello, Ivan Bogeski   +6 more
wiley   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

The Role of Medical History and Allergic Tests in the Analysis of Antibiotic Allergy in the Pediatric Population

Allergies
According to parental reports, about 10% of children are believed to be allergic to at least one antibiotic, leading to the prescription of second line medications. This incurs higher costs, results in less effective treatments, and contributes to global
Margarita Dimitroglou, Dafni Moriki, Olympia Sardeli, Elpiniki Kartsiouni, Despoina Koumpagioti, Angeliki Galani, Vassiliki Papaevangelou, Konstantinos Douros   +7 more
doaj   +1 more source

Skin Tests in Nsaids Hypersensitivity

Journal of Allergy and Clinical Immunology, 2007
Prick tests are more specific but less sensitive than ID which can give false positive results. 3 NSAIDS groups can be considered: Aspirin, diclofenac and metamizol with a higher percentage of positivity. For others NSAIDS including the newer coxibs positivity around 50%. Nimesulid and acetaminophen with a lower of positivity. Skin tests can be used in
Palma-Carlos Ag, Medina M, Palma-Carlos Ml   +2 more
openaire   +4 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Research in Natural Laminar Flow and Laminar-Flow Control, part 2 [PDF]

Part 2 of the Symposium proceedings includes papers addressing various topics in basic wind tunnel research/techniques and computational transitional research.
Hefner, Jerry N., Sabo, Frances E.
core   +1 more source

Tuberculin Skin Testing in Children

Emerging Infectious Diseases, 2006
In 1996, the American Academy of Pediatrics (AAP) recommended targeted tuberculin skin testing (TST) of children while discouraging routine TST of children without risk factors for tuberculosis (TB). Recent studies have provided evidence in support of the targeted TST and recommendations that favor risk assessment over universal screening with TST ...
Marina Reznik, Philip O. Ozuah
openaire   +4 more sources

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Secondary bacterial infections of buruli ulcer lesions before and after chemotherapy with streptomycin and rifampicin [PDF]

, 2013
Buruli ulcer (BU), caused by Mycobacterium ulcerans is a chronic necrotizing skin disease. It usually starts with a subcutaneous nodule or plaque containing large clusters of extracellular acid-fast bacilli.
AA Pahlevan, AB Wysocki, Albert Paintsil, AO Shittu, AO Shittu, AW Bauer, Benjamin Anku, Cynthia Kwakye-Maclean, D Yeboah-Manu, Dorothy Yeboah-Manu, E Coutanceau, E Coutanceau, E Mensah-Quainoo, Evelyn Owusu-Mireku, G Bori, Gerd Pluschke, Grace S. Kpeli, HC Gram, IG Schraibman, Isaac Lamptey, J Guarner, J Hayman, JP Heggers, K GjØdsbØl, K Twum-Danso, KM Dobos, KM George, KM George, Kobina Asan-Ampah, Kwabena Quenin-Fosu, L Katz, M Cruickshank, M Karas, Marie-Thérèse Ruf, MC Robson, Mercy Newman, NA Stotts, NS Levine, Pamela L. C. Small, PG Bowler, RC Daltery, S Adusumilli, S Etuaful, W Curreri, W Majewski, WA Nienhuis   +45 more
core   +3 more sources

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source