Results 51 to 60 of about 552 (177)
Gαi1/3 Is a Novel Regulatory Target for RANKL Signal Transduction and Osteoporosis
Advanced Science, Volume 13, Issue 20, 9 April 2026.ABSTRACT Osteoporosis, characterized by progressive bone loss and increased fracture risk, is a growing concern as the population ages. Current treatments, though advanced, remain limited, underscoring the necessity for novel therapeutic targets. Recent studies have shown that the immune system plays a key role in osteoporosis, with osteoclasts driving
Chaowen Bai +15 more
wiley +1 more source
Endogenous GIP signaling is indispensable for DPP‐4 inhibitor‐mediated metabolic control in mice
Journal of Diabetes Investigation, Volume 17, Issue 4, Page 567-575, April 2026.This study reveals that the metabolic benefits of DPP‐4 inhibitors, including improved glucose tolerance and reduced body weight, are completely abolished in GIP receptor‐deficient mice. These findings establish that endogenous GIP signaling, rather than GLP‐1, is the indispensable key player for the efficacy of this drug class.
Saki Kubota‐Okamoto +17 more
wiley +1 more source
How We Built a Spatial Subject Classification Based on Wikidata
Code4Lib Journal, 2021 From the fall of 2017 to the beginning of 2020 a project had been carried out to upgrade spatial subject indexing in North Rhine-Westphalian Bibliography (NWBib) from uncontrolled strings to controlled values.
Adrian Pohl
doaj
Il Nuovo soggettario come servizio per il mondo dei linked data
JLIS.it, 2012 Nuovo soggettario (NS), edited by the National Central Library of Florence, is the Italian subject indexing tool for various types of resources. It has been developed in compliance with the IFLA recommendations, and other international standards in the ...
Giovanni Bergamin, Anna Lucarelli
doaj +1 more source
Towards a Graffiti Thesaurus in SKOS
, 2022 This presentation was given by Jona Schlegel and Massimiliano Carloni during Session D of the goINDIGO 2022 international graffiti symposium. Awareness of the 20th-century graffiti phenomenon spread globally with movies like Wild Style (1983) and photo books like Subway art (1984). To educate the public on the graffiti movement, graffiti specific terms
Schlegel, Jona +3 more
openaire +1 more source
The FASEB Journal, Volume 40, Issue 6, 31 March 2026.Effects of PEPCK deficiency in Trypanosoma cruzi bioenergetics and life stages. ABSTRACT Trypanosoma cruzi, the causative agent of Chagas disease, possesses glycosomes—unique organelles that house key metabolic enzymes, several of which are promising therapeutic targets.
Carolina S. D. Vieira +8 more
wiley +1 more source
Biotechnology Progress, Volume 42, Issue 2, March/April 2026.This study established the first creation of a commercially available double GS knockout (DKO) from a single KO in CHO‐K1 cells, called CleanCut GS CHO using Cas‐CLOVER. When combined with the Harbor‐IN transposase system, CleanCut GS CHO cells demonstrated a highly antibody productivity.
Cintia Gomez Limia +7 more
wiley +1 more source
Supply chain knowledge management: A linked data-based approach using SKOS
Dyna, 2015 Hoy en día, el conocimiento es una poderosa herramienta para obtener beneficios en cualquier organización. Especialmente cuando las tecnologías de la Web semántica son adaptadas a los requerimientos de las empresas.
Cristian Aarón Rodríguez-Enríquez +3 more
doaj
, 2017 Bacheloroppgave i Retail management fra Handelshøyskolen BI ...
Nilsen, Martine, Homleid, Malin
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FEBS Letters, Volume 600, Issue 3, Page 370-382, February 2026.At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom +3 more
wiley +1 more source