Results 131 to 140 of about 148,675 (284)

Thalamic connectivity mirrors spatial maps of network dysfunction in nonlesional focal epilepsy

Epilepsia, EarlyView.
Abstract Objective Focal epilepsy is increasingly conceptualized as a network disorder, yet the extent to which network dysfunction reflects a shared phenotype remains unknown. Spatially conserved patterns of network dysfunction may implicate a centralized mechanism underlying widespread impairment.
Joline M. Fan, Ehsan Tadayon, Kiwamu Kudo, Kamalini G. Ranasinghe, Anne M. Findlay, Robert C. Knowlton, Vikram R. Rao, Srikantan S. Nagarajan   +7 more
wiley   +1 more source

Armodafinil in the treatment of sleep/wake disorders

Neuropsychiatric Disease and Treatment, 2010
Jonathan RL Schwartz1,Thomas Roth2, Chris Drake21INTEGRIS Sleep Disorders Center and University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; 2Sleep Disorders and Research Center, Henry Ford Hospital, Detroit, MI, USAAbstract: Excessive ...
Jonathan RL Schwartz, Thomas Roth, Chris Drake   +2 more
doaj  

Improving Sleep: Promoting Sleep Hygiene Techniques [PDF]

, 2018
About one third of adults in the U.S. get insufficient sleep, defined as less than 7 hours of sleep per 24 hour period, with similar statistics in Chittenden County, Vermont.
Clifford, Katherine
core   +1 more source

Tissue oxygenation dynamics during transition from seizure to spreading depolarization in rat brain

Epilepsia, EarlyView.
Abstract Objective Spreading depolarization (SD) is a phenomenon underlying various neurological conditions, including epilepsy. Researchers have suspected that local tissue oxygenation breakdown induces spontaneous SD. In this study, we investigated the relationship between spontaneous epileptic seizures and SD, with a focus on the role of local ...
Jiayang Liu, Bruce J. Gluckman
wiley   +1 more source

Circadian Rhythm Sleep-Wake Disorders: a Contemporary Review of Neurobiology, Treatment, and Dysregulation in Neurodegenerative Disease. [PDF]

Neurotherapeutics, 2021
Steele TA, St Louis EK, Videnovic A, Auger RR.   +3 more
europepmc   +1 more source

CaMKIIβ insufficiency disrupts cortical networks, producing aberrant low‐gamma oscillations and seizure susceptibility

Epilepsia, EarlyView.
Abstract Objective Pathogenic variants in the calcium/calmodulin‐dependent protein kinase II B gene (CAMK2B) have been associated with neurodevelopmental disorders, including epilepsy, yet the mechanisms underlying cortical dysfunction remain largely unclear.
Hiroki Mutoh, Kazushi Aoto, Atsuo Fukuda, Hirotomo Saitsu   +3 more
wiley   +1 more source

Epileptic encephalopathy with spike‐and‐wave activation in sleep associated with Tatton–Brown–Rahman syndrome responsive to highly purified cannabidiol

Epileptic Disorders, EarlyView.
Anita N. Datta
wiley   +1 more source

An n‐of‐1 gene‐directed drug repurposing trial for an ultrarare genetic condition

Epilepsia, EarlyView.
Abstract Objective Gain‐of‐function (GoF) variants in the KCNC1 potassium channel subunit gene (Kv3.1) cause motor/cognitive delays and hypotonia and have been associated with seizures. Fluoxetine has inhibitory effects on Kv3.1. However, open‐label nonrandomized administration is insufficient to guide clinical decision‐making in ultrarare conditions ...
Vedika Jha, Christina Tsetsos, Mark Bedford, Gregory Costain, Sunita Vohra, Juan Pablo Diaz Martinez, Elise Heon, Jacob Vorstman, Carolina Gorodetsky, Ajoy Vincent, Jesiqua Rapley, Lori Anderson, Evdokia Anagnostou, Danielle A. Baribeau   +13 more
wiley   +1 more source

Validation of sleep-wake estimation from thigh-worn accelerometers against polysomnography in adolescents with and without mental disorders

BMC Psychiatry
Background To validate the estimation of sleep-wake patterns using thigh-worn accelerometers against polysomnography —the gold standard for sleep assessment—in adolescents with and without mental disorders from the Danish High Risk and Resilience Study ...
Martin Wilms, Anne Søndergaard, Poul Jørgen Jennum, Peter J. Johansson, Pasan Hettiarachchi, Sinnika Birkehøj Rohd, Anette Faurskov Bundgaard, Andreas Faergemand Laursen, Marta Schiavon, Doris Helena Bjarnadóttir Streymá, Maja Gregersen, Mette Falkenberg Krantz, Lotte Veddum, Aja Neergaard Greve, Nicoline Hemager, Ole Mors, Anne Amalie Elgaard Thorup, Merete Nordentoft, Lone Baandrup   +18 more
doaj   +1 more source

Setting Objective Clinical Assessment Tools for Circadian Rhythm Sleep-Wake Disorders - A Community-Based Cross-Sectional Epidemiological Study. [PDF]

Nat Sci Sleep, 2021
Frangopoulos F, Nicolaou I, Zannetos S, Economou NT, Adamide T, Georgiou A, Nikolaidis PT, Rosemann T, Knechtle B, Trakada G.   +9 more
europepmc   +1 more source