Results 91 to 100 of about 323,696 (314)

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Robust sliding mode control for discrete stochastic systems with mixed time delays, randomly occurring uncertainties, and randomly occurring nonlinearities

, 2012
This is the post-print version of the paper. The official published version can be accessed from the link below - Copyright @ 2012 IEEEThis paper investigates the robust sliding mode control (SMC) problem for a class of uncertain nonlinear stochastic ...
Zidong Wang, Wang, Z, Stergioulas, LK, Jun Hu, Hu, J, Lampros K. Stergioulas, Gao, H, Huijun Gao   +7 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Performance evaluation of multilayer thin film coatings under mixed rolling-sliding dry contact conditions [PDF]

, 2010
This paper focuses on the application of advanced finite element analysis to simulate the response of complex multilayer coatings when subjected to mixed rolling-sliding dry contact conditions, typical of those experienced by heavily loaded gear tooth ...
Wrobel, LC, Mao, K, Mao, Ken, Wrobel, L. C., Farley, J, Farley, Jonathan   +5 more
core   +1 more source

V-notch to Prevent Sliding of Crimpable Hook

Orthodontic Journal of Nepal, 2015
En-mass retraction of anterior teeth most commonly involves the use of crimpable hooks which often dislodge when retracting force is applied. A V-notch distal to the hook may prevent such sliding when sandblasting and dental adhesives are not ...
Rajesh Gyawali, Praphat Ranjan Pokharel, Gunjan Kumar Shrestha, Jamal Giri   +3 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Tactile Sliding Behavior of R2R Mass-Produced PLLA Nanosheet towards Biomedical Device in Skin Applications

Nanomaterials, 2018
In this research, sliding friction was measured between the fingertip and nanosheet on a silicon substrate under two conditions: dry and wet. By using a force transducer, the tactile friction force and applied load were measured.
Sheng Zhang, Yoshitomo Kai, Yuta Sunami
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

“WHAT IS A WORK?”: BETWEEN STABILITY AND SLIDING IN THE INTERNET AGE

Texto Livre: Linguagem e Tecnologia, 2016
This paper, based on the Discourse Analysis perspective articulated by Pêcheux, discusses the concept of work by analyzing the sense effects produced within the official discourse and in the debate discourse – which are materialized in the Copyright Laws
Paula Daniele Pavan
doaj   +1 more source