Results 81 to 90 of about 920,377 (338)

Tribological Performance of Electrochemically Textured EN-GJS 400-15 Spheroidal Cast Iron

Lubricants
This paper presents an experimental study of uniform and variable texture patterns on a honed EN-GJS 400-15 spheroidal graphite cast iron surface. Textured samples were fabricated using a CNC electrochemical jet machining technique and tested against a ...
Peng Jiang, Jonathon Mitchell-Smith, John Christopher Walker   +2 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Continuous Adaptive Finite Reaching Time Control and Second-Order Sliding modes [PDF]

, 2013
This paper focuses on the design of adaptive finite reaching time control for first- and second-order dynamic systems with perturbation terms given in a regressive form. The uncertainties considered here are assumed to be bounded with unknown bounds. The
Spurgeon, Sarah K., Kochalummoottil, J., Shtessel, Yuri B., Edwards, Christopher   +3 more
core   +1 more source

Analysis of kinematic and energy parameters of electric locomotive wheel–rail adhesion

Вестник Научно-исследовательского института железнодорожного транспорта
Introduction. Electric locomotive wheel–rail adhesion is determined by various parameters (kinematic and energetic) that affect the mass and speed of the train, energy consumption, etc.
A. A. Baklanov
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Small-scale instabilities in dynamical systems with sliding [PDF]

, 2010
NOTICE: this is the author’s version of a work that was accepted for publication in Physica D: Nonlinear Phenomena . Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality ...
Kowalczyk, P., Sieber, J., Sieber, J, Kowalczyk, P   +3 more
core   +1 more source

SELECTION OF METHOD FOR REGULATION OF TRACTOR PROPULSION ASYNCHRONOUS ELECTRIC MOTOR AND CONSTRUCTION OF MECHANICAL CHARACTERISTICS

Наука и техника, 2015
Nowadays the work is in progress to develop wheeled and caterpillar tractors with electromechanical transmission. Range of changes in transmission gear ratio while using propulsion electric motor depends on mechanical characteristics of a tractor ...
Ch. I. Zhdanovich, N. V. Kalinin
doaj  

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source