Results 51 to 60 of about 821,881 (278)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Law of Friction: from Tribology to Tribo-Fatigue. Report 1. Classical Law of (Dry) Friction and Need for its Adjustment

Механика машин, механизмов и материалов, 2019
To date, many laws of Nature have been discovered. The knowledge of each of them led to the accelerated development of the relevant sections of Science and further, as a rule, to progress in any practical area of the community of people. The empirical
Leonid A. Sosnovskiy
doaj  

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Softness Perception Interfered by Friction in Gliding Virtual Surfaces

IEEE Access
Recent studies have shown that surface friction affects softness perception when objects are slid over using fingers. This study examines whether this phenomenon extends to interactions with virtual objects using a stylus-based haptic interface, which ...
Hongbo Wang, Shogo Okamoto
doaj   +1 more source

Sliding hernia uterus inguinale in a child

Saudi Journal for Health Sciences, 2018
Uterine adnexa may be the content of the inguinal hernial sac in up to one-fifth of the pediatric female patients. Inguinal hernia containing uterus is known as “hernia uterus inguinale” which is a very rare condition.
Rahul Gupta
doaj   +1 more source

Transverse thermal depinning and nonlinear sliding friction of an adsorbed monolayer

, 2000
We study the response of an adsorbed monolayer under a driving force as a model of sliding friction phenomena between two crystalline surfaces with a boundary lubrication layer.
B. Bhushan, B. N. J. Persson, B. N. J. Persson, B. N. J. Persson, B. N. J. Persson, C. Reichhardt, E. Granato, Enzo Granato, G. Grüner, H. Yoshizawa, J. N. Israelachvili, J. Y. Lin, M. Heuberger, M. P. Allen, N. B. Kopnin, O. M. Braun, P. A. Thompson, P. Le Doussal, S. C. Ying, T. Giamarchi   +19 more
core   +1 more source

Sliding-mode neuro-controller for uncertain systems [PDF]

, 2007
In this paper, a method that allows for the merger of the good features of sliding-mode control and neural network (NN) design is presented. Design is performed by applying an NN to minimize the cost function that is selected to depend on the distance ...
Abidi, Khalid Seyed, Sabanovic, Asif, Yıldız, Yıldıray, Yildiz, Yildiray, Şabanoviç, Asif   +4 more
core   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Understanding the friction laws of Amontons and Coulomb by evaluating the real contact area

Friction
Friction is a complex phenomenon that depends on many parameters. Despite this, we still rely on and describe friction in the vast majority of cases with a single value, namely, the coefficient of friction (µ), as first proposed by Amontons in 1699 ...
Mitjan Kalin, Petra Jan
doaj   +1 more source

Velocity dependence of friction of confined polymers [PDF]

, 2009
We present molecular dynamics friction calculations for confined hydrocarbon solids with molecular lengths from 20 to 1400 carbon atoms. Two cases are considered: (a) polymer sliding against a hard substrate, and (b) polymer sliding on polymer.
Persson, B. N. J., Samoilov, V. N., Sivebaek, I. M.   +2 more
core   +1 more source