Results 91 to 100 of about 93,900 (314)

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Sliding-Mode-Based Control Strategy for a Solar Multi-Port Three-Level DC-DC Converter Under Harsh System Uncertainty

, 2023
Sliding-Mode-Based Control Strategy for a Solar Multi-Port Three-Level DC-DC Converter Under Harsh System ...
Amir Ganjavi (15318031), Saman Asghari Gorji (13059219), Dezso Sera (15189388), Hoda Ghoreishy (16410000)   +3 more
core   +1 more source

Dynamic Sliding-Mode Control for T-S Fuzzy Singular Time-Delay Systems With ${H}_{\infty}$ Performance

IEEE Access, 2019
In this paper, we propose a novel sliding-mode control for Takagi-Sugeno (T-S) fuzzy singular system with time-delay and mismatched uncertainties and disturbances.
Jiasheng Shi, Qingling Zhang
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Adaptive Synchronization for Two Different Stochastic Chaotic Systems with Unknown Parameters via a Sliding Mode Controller

Abstract and Applied Analysis, 2013
This paper investigates the problem of synchronization for two different stochastic chaotic systems with unknown parameters and uncertain terms. The main work of this paper consists of the following aspects.
Zengyun Wang, Lihong Huang, Xuxin Yang, Dingyang Lu   +3 more
doaj   +1 more source

Towards improving the Statscan X-ray image quality through sliding mode control of the C-arm

, 2012
Includes abstract.Includes bibliographical references.This dissertation investigates methods for improving the image quality of a digital radiography system. The Lodox Statscan™ X-ray system provides a full-body scanned image for initial diagnosis.
Esmail, Mohammed
core  

Design of self-learning fuzzy sliding mode controllers based on genetic algorithms

, 2011
In this paper, genetic algorithms were applied to search a sub-optimal fuzzy rule-base for a fuzzy sliding mode controller. Two types of fuzzy sliding mode controllers based on genetic algorithms were proposed.
林信成 = Lin, Sinn-cheng ; Chen, Yung-yaw
core   +1 more source