Results 81 to 90 of about 93,900 (314)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Integral Sliding Mode Control for a Class of Nonlinear Multi-Agent Systems With Multiple Time-Varying Delays

IEEE Access
This paper deals with the stability of nonlinear multi-agent systems (MASs) with multiple time delays. A class of multi-agent system (MAS) is constructed considering the effects of multiple time delays, nonlinearity, and uncertainty.
Jia Feng, Wei Wang, Hong-Bing Zeng
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Application of moving sliding mode control for a DC motor driven four-bar mechanism

Advances in Mechanical Engineering, 2018
The angular velocity of the input link of a mechanism fluctuates due to the inertia of links and the external forces, although it is generally assumed constant in design.
Orhan Çakar, Alper Kadir Tanyıldızı
doaj   +1 more source

Integral sliding mode control for active suspension systems of half-vehicle model

Mechanical Engineering Journal, 2015
This paper proposes a design method of sliding mode controller with the robustness against actuator uncertainty for active suspension systems of half-vehicle model. The features of the proposed sliding mode controller are not to require any force sensors
Shigehiro TOYAMA, Fujio IKEDA
doaj   +1 more source

Multirate output feedback based digital redesign of sliding mode control algorithms

, 2006
Though continuous-time sliding mode control has a variety of desirable properties, its discrete-time counterpart does not guarantee the same performance.
BANDYOPADHYAY, B, ABERA, AGE, Janardhanan, S., JANARDHANAN, S, Abera, A.G., Bandyopadhyay, B.   +5 more
core   +1 more source

Skyhook surface sliding mode control on semi-active vehicle suspension systems for ride comfort enhancement [PDF]

, 2009
A skyhook surface sliding mode control method was proposed and applied to the control on the semi-active vehicle suspension system for its ride comfort enhancement.
Yi Chen, Chen, Y.
core   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Event-Triggered Sliding Mode Control of Switched Neural Networks with Mode-Dependent Average Dwell Time

, 2021
This paper is concerned with the sliding mode control problem for a class of continuous-time switched neural networks with mode-dependent average dwell time (MDADT).
Wang, Y, Yan, H, Chen, S, Zhan, X, Zhang, H, Yang, F   +5 more
core   +1 more source