Results 41 to 50 of about 1,272,466 (247)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Development of gross motor skills and nutrition literacy among inclusive junior high school students
Pedagogy of Physical Culture and SportsBackground and Study Aim. Slow learners in inclusive junior high schools often face difficulties in developing gross motor skills and possess limited nutritional literacy.
Ngatman Ngatman +4 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Identify Slow Learners in Math: Case Study in Rural Schools [PDF]
, 2023 — One way to identify slow learners is with an IQ (Intelligence Quotient) test. However, in rural schools, facilities for conducting IQ tests are very difficult to obtain, usually only in big cities.
Murdiyanto, Tri +2 more
core
Journal of Mathematics Instruction, Social Research and OpinionAlthough much research has highlighted slow learners' difficulties in learning mathematics, most studies have focused only on the final learning outcomes without delving into the thinking processes during problem-solving.
Sulfiati, Irwan Akib, Muhammad Muzaini
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
A study on the impact of social skill Training on social adjustment and academic performance in slow learners [PDF]
فصلنامه نوآوریهای آموزشی, 2010 The present study was designed to investigate the impact of social skill training on social adjustment and academic performance in slow learners. For this purpose, 50 male slow learners in second grade of primary schools in Khodabandeh (a city of Zanjan ...
Ahmad Beh-Pajooh +3 more
doaj
Jurnal PAJAR (Pendidikan dan Pengajaran), 2020 Slow learner children have barriers in complex thinking processe especially in language. Low IQ levels craft them difficulties to identify sentence structure which result in the disruption of their sentence production process.
Wardatul Yunita Tikasari
doaj +1 more source
FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source