Results 21 to 30 of about 27,932 (217)

A Novel Interaction of Slug (SNAI2) and Nuclear Actin

Cells
Actin is a protein of central importance to many cellular functions. Its localization and activity are regulated by interactions with a high number of actin-binding proteins.
Ling Zhuo, Jan B. Stöckl, Thomas Fröhlich, Simone Moser, Angelika M. Vollmar, Stefan Zahler   +5 more
doaj   +1 more source

Epithelial-Mesenchymal Transition Proteins in Neuroendocrine Neoplasms: Differential Immunohistochemical Expression in Different Sites and Correlation with Clinico-Pathological Features

Diagnostics, 2020
The first step leading to metastasis, or for the acquisition of local invasiveness, involves changes in the phenotype of neoplastic cells in the primary tumor.
Elia Guadagno, Severo Campione, Sara Pignatiello, Giorgio Borrelli, Gianfranco De Dominicis, Nicolina De Rosa, Marialaura Del Basso De Caro   +6 more
doaj   +1 more source

Influence of slug defence mechanisms on the prey preferences of the carabid predator Pterostichus melanarius (Coleoptera: Carabidae)

European Journal of Entomology, 2004
Two-choice experiments on prey preferences of a generalist predator Pterostichus melanarius, and five species of slug prey, were conducted in the laboratory. Different preferences of P. melanarius for each of the slug species are described.
Pavel FOLTAN
doaj   +1 more source

Slug Mediates MRP2 Expression in Non-Small Cell Lung Cancer Cells

Biomolecules, 2022
Transcriptional factors, such as Snail, Slug, and Smuc, that cause epithelial-mesenchymal transition are thought to regulate the expression of Ezrin, Radixin, and Moesin (ERM proteins), which serve as anchors for efflux transporters on the plasma ...
Xieyi Zhang, Wangyang Liu, Kazue Edaki, Yuta Nakazawa, Saori Takahashi, Hiroki Sunakawa, Kenta Mizoi, Takuo Ogihara   +7 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Upregulation of SLUG expression in canine mammary gland tumors and its prognostic significance

BMC Veterinary Research, 2023
Background SLUG (also known as snai2), which is a transcription factor in epithelial–mesenchymal transition (EMT), plays an important role in tumorigenesis.
Soo-Bin Cheon, Wan Hee Kim
doaj   +1 more source

Generation of Controlled Liquid–Liquid Slug Flow by Interlocking Two Diaphragm Pumps

Separations, 2022
From the viewpoint of resource and energy-saving, the high extraction rate of alternating liquid–liquid flow (slug flow) is important given that it enables its novel use in extraction.
Akinori Muto, Hidetaka Abe, Keita Kanki, Takashi Fukuda, Shin-ichiro Kawasaki   +4 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Stream Discharge Determinations Using Slug Additions and Specific Conductance

Water Resources Research
Stream discharge is often determined by wading the stream and measuring the point velocity at fixed widths and depths. However, there are conditions when wading measurements are not safe or the measurements are poor because of high turbulence, rocky ...
R. Blaine McCleskey, Robert L. Runkel, Sheila F. Murphy, David A. Roth   +3 more
doaj   +1 more source

Absence of EpCAM in cervical cancer cells is involved in slug induced epithelial-mesenchymal transition

Cancer Cell International, 2021
Background Slug (Snai2) is a pivotal player in initiating epithelial-mesenchymal transition (EMT) through its trans-suppression effect on E-cadherin in various normal and malignant cells.
Xian Liu, Qian Feng, Yanru Zhang, PengSheng Zheng, Nan Cui   +4 more
doaj   +1 more source