Results 91 to 100 of about 303,059 (302)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

From vulnerable to resilience: an assessment of small-scale fisheries livelihood in South Malang of Indonesia

Discover Sustainability
The livelihoods of small-scale fisheries in South Malang of Indonesia are being notably influenced by ecosystem degradation and climate change. Therefore, this study aims to investigate the vulnerability of small-scale fisheries in South Malang of ...
Puji Handayati, Ahmad Munjin Nasih, Indah Susilowati, Idris, Prateep Kumar Nayak, Bagus Shandy Narmaditya   +5 more
doaj   +1 more source

Assessing the sustainability of subsistence fisheries of small indigenous fish species: fishing mortality and exploitation of hill stream loaches in India

Aquatic Living Resources, 2017
Small, least conspicuous fish species are targeted through subsistence fisheries in many regions of the world, but little is known about their population dynamics or exploitation levels.
Keskar Ashwini, Raghavan Rajeev, Kumkar Pradeep, Padhye Anand, Dahanukar Neelesh   +4 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

International legal instruments relevant to fisheries and fishing communities : a handbook. Introduction [PDF]

, 2006
This handbook provides detailed information for a wide range of legal instruments relevant to fisheries and fishworkers. It covers 114 legal instruments, categorized into the following seven themes: Theme I.

core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Mapping place names for small-scale fisheries evaluation

Aquatic Living Resources
Fishers’ spatial knowledge encompasses a diverse array of social, ecological, technical, experiential, and learning knowledge derived from local environmental and sociocultural contexts.
Randriatsara Roddy M., Behivoke Faustinato, Ramahatratra Frédéric, Mahafina Jamal, Lamy Thomas, Léopold Marc   +5 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

From participation to governance : a critical review of the concepts of governance, co-management and participation, and their implementation in small-scale inland fisheries in developing countries [PDF]

This report reviews the role, nature and mechanisms of governance in inland fisheries. We do so by reviewing first the wider issues of governance, participation and co-management in natural resource management, and then focus on small-scale fisheries ...
BΘnΘ, C., Neiland, A.E.
core  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source