Results 91 to 100 of about 302,867 (282)
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Discover SustainabilityThe livelihoods of small-scale fisheries in South Malang of Indonesia are being notably influenced by ecosystem degradation and climate change. Therefore, this study aims to investigate the vulnerability of small-scale fisheries in South Malang of ...
Puji Handayati +5 more
doaj +1 more source
International legal instruments relevant to fisheries and fishing communities : a handbook. Theme V. Fishing vessels and safety at sea [PDF]
, 2006 This handbook provides detailed information for a wide range of legal instruments relevant to fisheries and fishworkers. It covers 114 legal instruments, categorized into the following seven themes: Theme I.
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Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Frontiers in Marine Science, 2018 Fisheries in Guinea Bissau contribute greatly to the economy and food security of its people. Yet, as the ability of the country to monitor its fisheries is at most weak, and confronted with a heavy foreign fleet presence, the impact of industrial ...
Jeremias Francisco Intchama +3 more
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Ecology and SocietyDespite the critical importance of small-scale fisheries for food security and well-being and the role of fishers as stewards of aquatic ecosystems, their future is uncertain. Tackling narratives that portray small-scale fisheries as obsolete, disparate,
Ignacio Gianelli +22 more
doaj +1 more source
From participation to governance : a critical review of the concepts of governance, co-management and participation, and their implementation in small-scale inland fisheries in developing countries [PDF]
This report reviews the role, nature and mechanisms of governance in inland fisheries. We do so by reviewing first the wider issues of governance, participation and co-management in natural resource management, and then focus on small-scale fisheries ...
BΘnΘ, C., Neiland, A.E.
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Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
PLoS ONE, 2015 Globally, small-scale fisheries are influenced by dynamic climate, governance, and market drivers, which present social and ecological challenges and opportunities.
Stacy E Aguilera +17 more
doaj +1 more source