Results 231 to 240 of about 12,783,707 (261)

CXCL10/SLC11A1 Axis Exacerbates Septic Liver Injury by Regulating Neutrophil Extracellular Traps Formation to Drive Macrophage Pro‑Inflammatory Polarization

Advanced Science, EarlyView.
In sepsis‐induced liver injury, marked neutrophil infiltration correlates with disease severity. Neutrophil SLC11A1 drives intracellular Fe2+ and ROS via the Fenton reaction, promoting NETs formation. Hepatocyte‐derived CXCL10 recruits neutrophils and activates the JAK/STAT1/SLC11A1 axis, enhancing NETs‐mediated inflammation.
Haiping Lin, Shicong Zheng, Pei Song, Jie Chang, Zewei Chen, Cang Li, Min Yu, Lude Wang, Shian Yu   +8 more
wiley   +1 more source

Landscape of Cell States and Multicellular Ecotypes in Non-Small Cell Lung Cancer. [PDF]

Int J Mol Sci
Li H, Jiang Y, Huo Z, Li S, Luo X, Xie Y, Xi Q, Wang S, Yang L.   +8 more
europepmc   +1 more source

PFKFB4 Deubiquitination by USP10 Enhances Fumarate Metabolism to Orchestrate the KDM1A/Rad51 Axis and Confer Radioresistance in Lung Cancer

Advanced Science, EarlyView.
USP10 binds to and stabilizes PFKFB4, enhancing glycolytic ATP production, which activates the urea cycle and elevates fumarate. This inhibits histone demethylase KDM1A, leading to increased H3K4me1 enrichment at the Rad51 promoter and direct activation of Rad51 transcription, which confers lung cancer radioresistance. The PFKFB4 inhibitor 5MPN targets
Yunshang Chen, Zilong Wu, Yongqiang Yang, Ruoxin Fang, Huichan Xue, Rui Zhou, Gang Wu, Xiaohua Jie   +7 more
wiley   +1 more source

Guideline concordance of stage IIIA non-small-cell lung cancer treatment in the Australian setting. [PDF]

Intern Med J
Ross G, Conron M, Wright G, Denton E.
europepmc   +1 more source

Mechanisms of LARP7 in regulating the progression of non-small cell lung cancer. [PDF]

J Thorac Dis
He J, Li C, Liu L, Qian X, Li F, Zhang L, Wang C, Qin H, Ding R.   +8 more
europepmc   +1 more source

PCK2 Inhibition Reverses Cisplatin Resistance of Non-Small Cell Lung Cancer by Triggering Ferroptosis. [PDF]

FASEB J
Liu J, Wang Z, Gu C, Chen Y, Yang Y, Zhu J, Zhang Y, Shao Y, Pang X, Ge Y, Qian H, Huang JA, Liu Z, Zeng Y, Ji C.   +14 more
europepmc   +1 more source

Small Cell Lung Cancer Associated With Cystic Airspace: A Case Report and Literature Review. [PDF]

Respirol Case Rep
Shimada H, Inoue Y, Matsubara O, Yamamoto M, Yamashita S, Hara T, Yamanaka K, Jinn Y.   +7 more
europepmc   +1 more source

Advancing Clinical Research

Advanced Science, EarlyView.
wiley   +1 more source