Results 41 to 50 of about 10,585,232 (232)

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

A case of pancreatic small cell neuroendocrine carcinoma associated with SIADH

, 2016
A case of pancreatic small cell neuroendocrine carcinoma associated with ...
MENE', Paolo, PANZUTO, Francesco, Pizzichini, Patrizia, FESTA, Stefano, PILOZZI, Emanuela, RINZIVILLO, MARIA, Prosperi, Daniela, IANNICELLI, Elsa, Pescatori, Lorenzo Carlo, Capurso, Gabriele, Fave, Gianfranco Delle, Iaquinto, Gaetano, Panzuto F, Prosperi D, Delle Fave G, Capurso G, Pilozzi E, Festa S, Iaquinto G, Rinzivillo M, Pescatori LC, Iannicelli E, Mene P, Pizzichini P   +23 more
core   +1 more source

A case of alpha-fetoprotein-positive thymic small cell carcinoma: a case report

Surgical Case Reports, 2023
Background An alpha-fetoprotein (AFP)-positive neuroendocrine tumor of the thymus is a rare thoracic malignancy. Few cases of AFP-positive thymic large cell neuroendocrine carcinoma have been reported, with no known previous report of an AFP-positive ...
Masao Kobayashi, Soichiro Funaki, Eriko Fukui, Eiichi Morii, Yasushi Shintani   +4 more
doaj   +1 more source

Emerging Therapeutic Concepts and Latest Diagnostic Advancements Regarding Neuroendocrine Tumors of the Gynecologic Tract

Medicina, 2021
Neuroendocrine neoplasms (NENs) are particularly rare in all sites of the gynecological tract and include a variety of neoplasms with variable prognosis, dependent on histologic subtype and site of origin.
Tiberiu-Augustin Georgescu, Roxana Elena Bohiltea, Octavian Munteanu, Florentina Furtunescu, Antonia-Carmen Lisievici, Corina Grigoriu, Florentina Gherghiceanu, Emilia Maria Vlădăreanu, Costin Berceanu, Ionita Ducu, Ana-Maria Iordache   +10 more
doaj   +1 more source

Small cell carcinoma - Urinary bladder

, 2022
Primary small-cell neuroendocrine carcinoma of the urinary bladder is a rare type of poorly differentiated and highly aggressive tumor. It accounts for
Dhara Patel, Isha Shah, U Suryanarayana
core   +1 more source

Targeting β2‐Adrenergic Receptor Stability With Lycorine Reveals a Host‐Directed Pathway for Antiviral Defense Against Poxviruses

Advanced Science, EarlyView.
Chronic stress drives autophagy‐mediated β2‐AR degradation, impairing antiviral immunity and promoting poxvirus lethality. Lycorine directly stabilizes β2‐AR to restore host defense, suppress excessive inflammation and improve survival. ABSTRACT Psychological stress is a pervasive yet poorly understood modulator of infectious disease outcomes. Here, we
Xin Zhang, Shuqin Xu, Zixuan Zhang, Chenwen Wan, Xiaoqin Wang, Peihua Wang, Huini Yang, Tianxiao Huang, Yijia Yuan, Faiza Atique, Rui Yang, Yingli He, Zhijun Liu   +12 more
wiley   +1 more source

Primary neuroendocrine small cell carcinoma of the parotid gland: A case report and literature review

口腔疾病防治, 2017
Primary neuroendocrine small cell carcinoma of the parotid gland is a rare malignant tumor, the clinical diagnosis is difficult. This article report a primary parotid neuroendocrine small cell carcinoma which was initially diag⁃ nosed of adenoid cystic
CHENG Zongsheng, JIN Yinhuan
doaj   +1 more source

Discovery and Optimization of AMT‐676, a CDH17‐Targeting ADC for the Treatment of Advanced Gastrointestinal Cancers

Advanced Science, EarlyView.
AMT‐676 is a novel antibody‐drug conjugate targeting CDH17, an adhesion molecule uniquely exposed on gastrointestinal tumor surfaces. Engineered with an optimized exatecan payload, it demonstrates profound tumor regression and a robust bystander effect across diverse preclinical models.
Ying‐nan Wang, Dan‐yun Ruan, Jing Shi, Yue Huang, Hui Sheng, Ya‐ling Huang, Linjie Ma, Lijun Wang, Caiwei Chen, Yixuan Wang, Yue Zhang, Yi Shen, Qing Zhang, Jianjian Zhang, Yanfang Tang, Jin‐ling Zhang, Jia‐jia Hu, Chen‐yi Wu, Jia‐ying Chen, Xun Meng, Shu‐Hui Liu, Feng Wang   +21 more
wiley   +1 more source

Small Cell Neuroendocrine Carcinoma of the Larynx: A Case Report and Literature Review

, 2016
WOS: 000396412600024A small cell neuroendocrine neoplasm of the larynx is a very rare and aggressive type of malignancy. Neuroendocrine carcinomas are most frequently seen in the lungs. The larynx is the most frequently involved site in the head and neck.
Ozdas, Talih, Ozdogen, Faith, Ozcan, Kursat Murat, Dere, Huseyin, Ikinciogullari, Aykut   +4 more
core   +1 more source