Results 61 to 70 of about 10,585,232 (232)

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Regulatory harmonization: Evolution, globalization and future directions

British Journal of Clinical Pharmacology, EarlyView.
Regulatory harmonization has become an increasingly important and accepted approach to streamline regulatory review processes and expedite access to safe, effective and high‐quality medicines globally. This review explores the evolution and current status of regulatory harmonization, convergence and reliance initiatives.
Orin Chisholm, Elaine Y. L. Blair, Christine Y. Lu   +2 more
wiley   +1 more source

Expression and Clinicopathologic Significance of Human Achaete-scute Homolog 1 in Pulmonary Neuroendocrine Tumors

Chinese Journal of Lung Cancer, 2010
Background and objective Human achaete-scute homolog 1 (hASH1) gene plays a critical role in development of the central nervous system, automatic nervous system, adrenal medullary chromaffin cells, thyroid C cells and pulmonary neuroendocrine cells.
Donghan ZHENG, Lijun WANG, Heyu HUANG, Rui LI, Zhiyong ZHONG, Fei LI, Daorong ZHANG   +6 more
doaj  

Postirradiated Neuroendocrine Carcinoma of the Sinonasal Tract

, 2011
OBJECTIVES/HYPOTHESIS: Neuroendocrine carcinoma (NEC) of the sinonasal tract is rare. In this present study, we report our treatment experience with sinonasal NEC. STUDY DESIGN: Retrospective case series.
王成平;謝佳潁;張逸良;婁培人;楊宗霖;丁禮莉;柯政郁, WANG, CHENG-PING;HSIEH, CHIA-YING;CHANG, YIH-LEONG;LOU, PEI-JEN;YANG, TSUNG-LIN;TING, LAI-LEI;KO, JENQ-YUH   +1 more
core   +2 more sources

Advances in combined neuroendocrine carcinoma of lung cancer

Pathology and Oncology Research
Lung cancer incidence and mortality rates are increasing worldwide, posing a significant public health challenge and an immense burden to affected families.
Zesen Han, Fujun Yang, Fang Wang, Huayu Zheng, Xiujian Chen, Hongyu Meng, Fenglei Li   +6 more
doaj   +1 more source

Neuroendocrine differentiation and neuroendocrine morphology as two different patterns in large-cell bronchial carcinomas: outcome after complete resection

World Journal of Surgical Oncology, 2006
Background In 1999, large-cell neuroendocrine carcinoma of the lung was introduced by the World Health Organization (WHO) as a new tumor entity in the group of non-small cell, epithelial tumors, a differentiated classification of neuroendocrine tumors of
Passlick Bernward, Kayser Gian, Jungraithmayr Wolfgang, Eggeling Stephan   +3 more
doaj   +1 more source

Exposure‐Response Analyses of Datopotamab Deruxtecan (Dato‐DXd), a TROP2‐Directed Antibody‐Drug Conjugate, in Advanced Non‐small Cell Lung Cancer

Clinical Pharmacology &Therapeutics, EarlyView.
Exposure‐response analyses supported a favorable benefit‐risk profile of Dato‐DXd at 6 mg/kg Q3W in patients with advanced nonsquamous NSCLC. Datopotamab deruxtecan (Dato‐DXd) is a trophoblast cell‐surface antigen‐2 (TROP2)‐directed antibody‐drug conjugate (ADC) that has demonstrated clinical activity in patients with NSCLC who have received prior ...
Ying Hong, Anna M. Mc Laughlin, Yuzhuo Pan, Sofia Friberg Hietala, Sophie Peigné, Michael Chargualaf, Zoey Tang, Diansong Zhou, Naoyuki Tajima, Malaz Abutarif, Tushar Garimella   +10 more
wiley   +1 more source

Anlotinib combined with tislelizumab in the treatment of primary small cell neuroendocrine carcinoma of the prostate: a case report and literature review

Frontiers in Immunology
Primary small cell neuroendocrine carcinoma of the prostate is extremely rare, highly aggressive, and has a very poor prognosis, with an overall survival typically not exceeding one year.
Xin Fei, Zhong Zheng, Zhen-ya Zhao, Da-wei Ren, Su-ying Wang, Shi-jie Ye, Lin-chun Liang, Da Li, Da Li, Xiao-long Jia, Qi Ma, Qi Ma   +11 more
doaj   +1 more source

Challenges and Pitfalls to Diagnosing NUTM1‐Rearranged Neoplasia of the Pancreas by Cytology and Ancillary Studies

Diagnostic Cytopathology, EarlyView.
ABSTRACT Fine‐needle aspiration cytology specimens are frequently utilized for ancillary studies to identify diagnostic and prognostic information. This case highlights diagnostic pitfalls and challenges in diagnosing NUTM1‐rearranged neoplasia on pancreatic cytology.
Terrance J. Lynn
wiley   +1 more source

FOXA2 is a sensitive and specific marker for small cell neuroendocrine carcinoma of the prostate [PDF]

, 2017
The median survival of patients with small cell neuroendocrine carcinoma is significantly shorter than that of patients with classic acinar-type adenocarcinoma.
Huang, Jiaoti, Witte, Owen N, Jung Wook Park, Owen N Witte, John K Lee, Jiaoti Huang, Lee, John K, Park, Jung Wook   +7 more
core   +1 more source