Results 91 to 100 of about 543,226 (367)

Functional expression and mutations of c-Met and its therapeutic inhibition with SU11274 and small interfering RNA in non-small cell lung cancer.

Cancer Research, 2005
Non-small cell lung cancer (NSCLC) is a difficult disease to treat. The c-Met receptor is an attractive potential target for novel therapeutic inhibition in human cancers.
P. Ma, R. Jagadeeswaran, S. Jagadeesh, M. Tretiakova, V. Nallasura, E. Fox, M. Hansen, E. Schaefer, K. Naoki, A. Lader, W. Richards, D. Sugarbaker, A. Husain, J. Christensen, R. Salgia   +14 more
semanticscholar   +1 more source

Transfer of small interfering RNA by electropermeabilization in tumor spheroids

Bioelectrochemistry, 2021
The ability to modulate deregulated genes by RNAi provides treatment perspectives in certain diseases including cancers. Electrotransfer of oligonucleotides was studied in vitro, showing a direct transfer of negatively charged siRNA across the plasma membrane into the cytoplasm.
Pelofy, Sandrine, Bousquet, Hugo, Gibot, Laure, Rols, Marie-Pierre, Golzio, Muriel   +4 more
openaire   +4 more sources

The Small interfering RNA pathway is not essential for Wolbachia-mediated antiviral protection in Drosophila melanogaster [PDF]

, 2012
Wolbachia pipientis delays RNA virus-induced mortality in Drosophila spp. We investigated whether Wolbachia-mediated protection was dependent on the small interfering RNA (siRNA) pathway, a key antiviral defense.
Hedges, Lauren M., Johnson, Karyn N., O'Neill, Scott L., Yamada, Ryuichi   +3 more
core   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Effect of interleukin-8 gene silencing with liposome-encapsulated small interfering RNA on ovarian cancer cell growth.

Journal of the National Cancer Institute, 2008
BACKGROUND Interleukin-8 (IL-8) is a proangiogenic cytokine that is overexpressed in many human cancers. We investigated the clinical and biologic significance of IL-8 in ovarian carcinoma using human samples and orthotopic mouse models.
W. Merritt, Yvonne G Lin, W. Spannuth, Mavis S. Fletcher, Aparna A. Kamat, Liz Y. Han, C. Landen, N. Jennings, Koen De Geest, R. Langley, G. Villares, A. Sanguino, S. Lutgendorf, G. Lopez-Berestein, M. Bar‐eli, Anil K Sood   +15 more
semanticscholar   +1 more source

Colored petri net modeling of small interfering RNA-mediated messenger RNA degradation

Advanced Biomedical Research, 2016
Background: Mathematical modeling of biological systems is an attractive way for studying complex biological systems and their behaviors. Petri Nets, due to their ability to model systems with various levels of qualitative information, have been wildly ...
Niloofar Nickaeen, Shiva Moein, Zarifeh Heidary, Jafar Ghaisari   +3 more
doaj   +1 more source

RNA-directed DNA methylation involves co-transcriptional small-RNA-guided slicing of polymerase V transcripts in Arabidopsis. [PDF]

, 2018
Small RNAs regulate chromatin modifications such as DNA methylation and gene silencing across eukaryotic genomes. In plants, RNA-directed DNA methylation (RdDM) requires 24-nucleotide small interfering RNAs (siRNAs) that bind to ARGONAUTE 4 (AGO4) and ...
Chory, Joanne, Duttke, Sascha H, Feng, Suhua, Gallego-Bartolome, Javier, Groth, Martin, Hetzel, Jonathan, Jacobsen, Steven E, Kuo, Hsuan Yu, Liu, Wanlu, Wang, Zonghua, Zhai, Jixian, Zhong, Zhenhui   +11 more
core   +1 more source

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source

Laser‐Triggered Small Interfering RNA Releasing Gold Nanoshells against Heat Shock Protein for Sensitized Photothermal Therapy

Advancement of science, 2016
The resistance of cancer cells to photothermal therapy is closely related to the overexpression of heat shock proteins (HSPs), which are abnormally upregulated when cells are under lethal stresses.
Zhaohui Wang, Siwen Li, Min Zhang, Yi Ma, Yuxi Liu, Weidong Gao, Jiaqi Zhang, Yueqing Gu   +7 more
semanticscholar   +1 more source

EGCG‐LYS Fibrils‐Mediated CircMAP2K2 Silencing Decreases the Proliferation and Metastasis Ability of Gastric Cancer Cells in Vitro and in Vivo

Advanced Science, 2023
Aberrant expression of circular RNAs (circRNAs) has been reported to play an important biological regulatory role in gastric cancer (GC). For the purpose of silencing cancer‐related genes, a new approach for cancer treatment using nanocarriers to deliver
Jiaqi Dong, Zhousan Zheng, Mi Zhou, Yunfei Wang, Jiajie Chen, Junjie Cen, Tiefeng Cao, Taowei Yang, Yi Xu, Guannan Shu, Xuanxuan Lu, Yanping Liang   +11 more
doaj   +1 more source