Results 91 to 100 of about 625,068 (254)
Delivery of small-interfering RNA (siRNA) to the brain [PDF]
Expert Opinion on Therapeutic Patents, 2009 Two fundamental difficulties in the delivery of drugs to treat central nervous system (CNS) diseases are the systemic delivery of therapeutics across the bloodbrain-barrier (BBB), and the targeting of drugs to specific tissues or cells within the brain.
openaire +3 more sources
Efficient Reduction of Target RNAs by Small Interfering RNA and RNase H-dependent Antisense Agents
Journal of Biological Chemistry, 2003 RNA interference can be considered as an antisense mechanism of action that utilizes a double-stranded RNase to promote hydrolysis of the target RNA. We have performed a comparative study of optimized antisense oligonucleotides designed to work by an RNA
T. Vickers +5 more
semanticscholar +1 more source
Optimal Electroporation Condition for Small Interfering RNA Transfection into MDA-MB-468 Cell Line
Iranian Journal of Medical Sciences, 2012 Background: Electroporation is a valuable tool for small interfering RNA (siRNA) delivery into cells because it efficiently transforms a wide variety of cell types.
Rita Arabsolghar, Mozhgan Rasti
doaj
Preparation of Carbon Nanotube Bioconjugates for Biomedical Applications [PDF]
arXiv, 2009 Biomedical applications of carbon nanotubes have attracted much attention in recent years. Here, we summarize our previously developed protocols for functionalization and bioconjugation of single wall carbon nanotubes (SWNTs) for various biomedical applications including biological imaging, sensing and drug delivery. Sonication of SWNTs in solutions of
arxiv
Bioinform., 2015 Summary: The Plant Small RNA Maker Site (P-SAMS) is a web tool for the simple and automated design of artificial miRNAs (amiRNAs) and synthetic trans-acting small interfering RNAs (syn-tasiRNAs) for efficient and specific targeted gene silencing in ...
N. Fahlgren +3 more
semanticscholar +1 more source
Coupling Aptamers to Short Interfering RNAs as Therapeutics
Pharmaceuticals, 2011 RNA-based approaches are among the most promising strategies aimed at developing safer and more effective therapeutics. RNA therapeutics include small non-coding miRNAs, small interfering RNA, RNA aptamers and more recently, small activating RNAs ...
Vittorio de Franciscis +4 more
doaj +1 more source
Nanodiamond as a vector for siRNA delivery to Ewing sarcoma cells [PDF]
arXiv, 2011 We investigated the ability of diamond nanoparticles (nanodiamonds, NDs) to deliver small interfering RNA (siRNA) in Ewing sarcoma cells, in the perspective of in vivo anti-cancer nucleic acid drug delivery. siRNA was adsorbed onto NDs previously coated with cationic polymer. Cell uptake of NDs has been demonstrated by taking advantage of NDs intrinsic
arxiv
مجله دانشکده پزشکی اصفهان, 2017 Background: Eukaryotic cells have membrane organelles. Due to the high prevalence of toxoplasmosis and lack of effective drugs especially on dormant cystic stages, we aimed adding small interfering RNA (siRNA) in culture medium on the proliferation ...
Abbas Ali Eskandarian +1 more
doaj
Small Interfering RNA Targeting Nerve Growth Factor Alleviates Allergic Airway Hyperresponsiveness
Molecular Therapy: Nucleic Acids, 2014 Airway hyperresponsiveness is the hallmark of allergic asthma and caused by multiple factors. Nerve growth factor (NGF), a neurotrophin, is originally known for regulation of neural circuit development and function.
Yi-Lien Chen +3 more
doaj +1 more source