Results 251 to 260 of about 6,122,708 (294)

Cholesterol Conjugates of Small Interfering RNA: Linkers and Patterns of Modification. [PDF]

Molecules
Chernikov IV, Ponomareva UA, Meschaninova MI, Bachkova IK, Vlassov VV, Zenkova MA, Chernolovskaya EL.   +6 more
europepmc   +1 more source

Development of Small Interfering RNA Loaded Cationic Lipid Nanoparticles for the Treatment of Liver Cancer with Elevated α-Fetoprotein Expression. [PDF]

ACS Bio Med Chem Au
Duangchan K, Limjunyawong N, Rodponthukwaji K, Ittiudomrak T, Thaweesuvannasak M, Kunwong N, Metheetrairut C, Sirivatanauksorn V, Sirivatanauksorn Y, Kositamongkol P, Mahawithitwong P, Tovikkai C, Nguyen KT, Srisawat C, Punnakitikashem P.   +14 more
europepmc   +1 more source

RNA Interference Unleashed: Current Perspective of Small Interfering RNA (siRNA) Therapeutics in the Treatment of Neuropathic Pain. [PDF]

ACS Pharmacol Transl Sci
Saha P, Sharma SS.
europepmc   +1 more source

Zerlasiran-A Small-Interfering RNA Targeting Lipoprotein(a): A Phase 2 Randomized Clinical Trial.

JAMA
Nissen SE, Wang Q, Nicholls SJ, Navar AM, Ray KK, Schwartz GG, Szarek M, Stroes ESG, Troquay R, Dorresteijn JAN, Fok H, Rider DA, Romano S, Wolski K, Rambaran C.   +14 more
europepmc   +1 more source

[Anti-inflammatory effects of cell membrane vesicle-mediated delivery of small interfering RNA targeting tumor necrosis factor-α on dental pulp stem cells]. [PDF]

Beijing Da Xue Xue Bao Yi Xue Ban
Gao R, Ma T, Wang R, Yin Y, Li R, Wang D, Xia B.   +6 more
europepmc   +1 more source

Augmented epigenetic repression of hepatitis B virus covalently closed circular DNA by interferon-α and small-interfering RNA synergy. [PDF]

mBio
Hu K, Zai W, Xu M, Wang H, Song X, Huang C, Liu J, Chen J, Deng Q, Yuan Z, Chen J.   +10 more
europepmc   +1 more source

Reactive Oxygen Species-Responsive Ferrocene Nanoparticles Delivering Small Interfering RNA Targeting NOP2/Sun RNA Methyltransferase Family Member 2 for Gastric Cancer Therapy. [PDF]

Biomater Res
Lu Y, Huang Y, Mao C, Shan P, Wu C, Zhu J, Lin Y, Li Z, Lu M.   +8 more
europepmc   +1 more source

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RNA interference and chemically modified small interfering RNAs

Current Opinion in Chemical Biology, 2004
RNA interference (RNAi) is a powerful biological process for specific silencing of gene expression in diversified eukaryotic cells and has tremendous potential for functional genomics, drug discovery through in vivo target validation, and development of novel gene-specific medicine.
Muthiah Manoharan
exaly   +3 more sources

Chemical Modification of Small Interfering RNA

2011
Chemically synthesized siRNAs are widely used for gene silencing. For in vitro applications, stability, delivery, and immunological issues are rarely problematic, but for in vivo applications the situation is different. Limited stability, undesirable pharmacokinetic behaviour, and unanticipated side effects from the immune system call for more careful ...
Bramsen, Jesper Bertram, Kjems, Jørgen; id_orcid 0000-0003-4128-9317   +1 more
openaire   +2 more sources