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Small interfering RNA (siRNA)-based therapeutics
Drug and Therapeutics Bulletin, 2023In early studies in simple organisms and mammalian cell lines, small interfering RNA (siRNA) molecules were found to allow experimental cleavage of intracellular messenger RNA (mRNA; the transcription product of a cell gene), reducing the levels of the proteins that would otherwise be formed by the action of the mRNA, thereby ‘silencing’ a specific ...
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RNA Interference and Small Interfering RNAs
ChemBioChem, 2001The term aRNA interferenceo (RNAi) was coined after the groundbreaking discovery that injection of double-stranded RNA (dsRNA) into the nematode Caenorhabditis elegans leads to specific silencing of genes highly homologous in sequence to the delivered dsRNA.
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Chemical Modification of Small Interfering RNA
2011Chemically synthesized siRNAs are widely used for gene silencing. For in vitro applications, stability, delivery, and immunological issues are rarely problematic, but for in vivo applications the situation is different. Limited stability, undesirable pharmacokinetic behaviour, and unanticipated side effects from the immune system call for more careful ...
Bramsen, Jesper Bertram, Kjems, Jørgen
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Small Interfering RNA for Effective Cancer Therapies
Mini-Reviews in Medicinal Chemistry, 2011Small interfering RNA (siRNA) has become a specific and powerful tool to turn off the expression of target genes, and has turned into a promising tool in molecular medicine. It can be targeted against cancer by several strategies. These include the suppression of overexpressed oncogenes, retarding cell division by interfering with cyclins and related ...
X, Wang, Y, Chen, J, Ren, X, Qu
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Oncogene Suppression by Small Interfering RNAs
Current Pharmaceutical Biotechnology, 2004Almost all human cancers have accumulated multiple genetic lesions including oncogenes. It is often unknown whether an oncogene is continuously required for tumorigenesis. Furthermore, it is very difficult to target an essential oncogene with drugs without affecting the corresponding nonmutated protooncogene or related factors.
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Small Interfering RNAs and RNA Therapeutics in Cardiovascular Diseases
2020Ribonucleic acid (RNA) is being exploited and understood in its many aspects of function and structure for development of valuable tools in the therapeutics of various diseases such as cardiovascular etc. The expanded knowledge regarding function of RNA in the genomics and inside the cell has dramatically changed the therapeutic strategies in the past ...
Parveen, Bansal, Malika, Arora
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RNA interference and chemically modified small interfering RNAs
Current Opinion in Chemical Biology, 2004RNA interference (RNAi) is a powerful biological process for specific silencing of gene expression in diversified eukaryotic cells and has tremendous potential for functional genomics, drug discovery through in vivo target validation, and development of novel gene-specific medicine.
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Photocaged Small Interfering RNA
Russian Journal of Bioorganic Chemistry, 2022E. A. Akhmetova +4 more
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Engineering Small Interfering RNAs by Strategic Chemical Modification
2012Synthetic small interfering RNAs (siRNAs) have revolutionized functional genomics in mammalian cell cultures due to their reliability, efficiency, and ease of use. This success, however, has not fully translated into siRNA applications in vivo and in siRNA therapeutics where initial optimism has been dampened by a lack of efficient delivery strategies ...
Bramsen, Jesper Bertram, Kjems, Jørgen
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