Results 261 to 270 of about 6,122,708 (294)

RNA Interference and Small Interfering RNAs

ChemBioChem, 2001
The term aRNA interferenceo (RNAi) was coined after the groundbreaking discovery that injection of double-stranded RNA (dsRNA) into the nematode Caenorhabditis elegans leads to specific silencing of genes highly homologous in sequence to the delivered dsRNA.
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The Role of Small Interfering RNAs in Hepatocellular Carcinoma

Journal of Gastrointestinal Cancer, 2023
Hepatocellular carcinoma (HCC), a primary liver cancer with high mortality, is the most common malignant tumor in the world. Currently, the effect of routine treatment is poor, especially for this kind of cancer with strong heterogeneity and late detection.
Feng, Chen, Wang, Zhang, Xinran, Gao, Hui, Yuan, Kehai, Liu   +4 more
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Small interfering RNA (siRNA)-based therapeutics

Drug and Therapeutics Bulletin, 2023
In early studies in simple organisms and mammalian cell lines, small interfering RNA (siRNA) molecules were found to allow experimental cleavage of intracellular messenger RNA (mRNA; the transcription product of a cell gene), reducing the levels of the proteins that would otherwise be formed by the action of the mRNA, thereby ‘silencing’ a specific ...
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Small Interfering RNAs and RNA Therapeutics in Cardiovascular Diseases

2020
Ribonucleic acid (RNA) is being exploited and understood in its many aspects of function and structure for development of valuable tools in the therapeutics of various diseases such as cardiovascular etc. The expanded knowledge regarding function of RNA in the genomics and inside the cell has dramatically changed the therapeutic strategies in the past ...
Parveen, Bansal, Malika, Arora
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Oncogene Suppression by Small Interfering RNAs

Current Pharmaceutical Biotechnology, 2004
Almost all human cancers have accumulated multiple genetic lesions including oncogenes. It is often unknown whether an oncogene is continuously required for tumorigenesis. Furthermore, it is very difficult to target an essential oncogene with drugs without affecting the corresponding nonmutated protooncogene or related factors.
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Derivation and function of small interfering RNAs and microRNAs

Virus Research, 2004
Small interfering RNA (siRNA) duplexes are generally produced by Dicer cleavage of double-stranded RNAs of frequently exogenous origin and can induce the cleavage and degradation of mRNAs bearing an identical sequence. In contrast, microRNAs (miRNAs) are encoded within the eukaryotic genome as short RNA hairpin structures.
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Photocaged Small Interfering RNA

Russian Journal of Bioorganic Chemistry, 2022
E. A. Akhmetova, D. V. Kim, A. S. Dome, M. I. Meschaninova, D. S. Novopashina   +4 more
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On the delivery of small interfering RNAs into mammalian cells

Expert Opinion on Drug Delivery, 2005
RNA interference is becoming the technique of choice for analysing gene function and drug target validation. In this process, sequence-specific gene inhibition is initiated by small RNA duplexes, known as small interfering RNAs (siRNAs). The possibility that exogenously delivered siRNAs or endogenously expressed hairpin siRNAs can cause the destruction
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Teprasiran, a Small Interfering RNA, for the Prevention of Acute Kidney Injury in High-Risk Patients Undergoing Cardiac Surgery: A Randomized Clinical Study

Circulation, 2021
Gabor Szabó, Mohamed G Atta
exaly  

Polycatechol Mediated Small Interfering RNA Delivery for the Treatment of Ulcerative Colitis

Advanced Functional Materials, 2021
Yiyun Cheng, Yiwen Li
exaly