Results 291 to 300 of about 485,750 (347)

Lepodisiran — A Long-Duration Small Interfering RNA Targeting Lipoprotein(a)

New England Journal of Medicine
BACKGROUND Elevated lipoprotein(a) concentrations are associated with atherosclerotic cardiovascular disease. The safety and efficacy of lepodisiran, an extended-duration, small interfering RNA targeting hepatic synthesis of lipoprotein(a), are unknown.
Steven E Nissen, Ann Marie Navar, Stephen J Nicholls   +2 more
exaly   +2 more sources

Photocaged Small Interfering RNA

Russian Journal of Bioorganic Chemistry, 2022
E. Akhmetova, D. V. Kim, A. S. Dome, M. Meschaninova, D. Novopashina   +4 more
semanticscholar   +2 more sources

Self‐Catalytic Small Interfering RNA Nanocarriers for Synergistic Treatment of Neurodegenerative Diseases

Advances in Materials, 2021
Gene therapy has shown great potential for neurodegenerative diseases with complex pathology. However, its therapeutic effect is limited due to the delivery barriers and its own single function.
Weihong Ji, Yan Li, Huan Peng, Ruichen Zhao, Jie Shen, Yanyue Wu, Jianze Wang, Qiulian Hao, Zhiguo Lu, Jun Yang, Xin Zhang   +10 more
semanticscholar   +1 more source

Chemical Modification of Small Interfering RNA

2011
Chemically synthesized siRNAs are widely used for gene silencing. For in vitro applications, stability, delivery, and immunological issues are rarely problematic, but for in vivo applications the situation is different. Limited stability, undesirable pharmacokinetic behaviour, and unanticipated side effects from the immune system call for more careful ...
Bramsen, Jesper Bertram, Kjems, Jørgen; id_orcid 0000-0003-4128-9317   +1 more
openaire   +2 more sources

RNA Interference and Small Interfering RNAs

ChemBioChem, 2001
The term aRNA interferenceo (RNAi) was coined after the groundbreaking discovery that injection of double-stranded RNA (dsRNA) into the nematode Caenorhabditis elegans leads to specific silencing of genes highly homologous in sequence to the delivered dsRNA.
openaire   +3 more sources

RNA interference and chemically modified small interfering RNAs

Current Opinion in Chemical Biology, 2004
RNA interference (RNAi) is a powerful biological process for specific silencing of gene expression in diversified eukaryotic cells and has tremendous potential for functional genomics, drug discovery through in vivo target validation, and development of novel gene-specific medicine.
Muthiah Manoharan
exaly   +3 more sources

Intratracheal Administration of Small Interfering RNA Targeting Fas Reduces Lung Ischemia-Reperfusion Injury*

Critical Care Medicine, 2016
Objectives: Lung ischemia-reperfusion injury is the main cause of primary graft dysfunction after lung transplantation and results in increased morbidity and mortality.
L. Del Sorbo, A. Costamagna, G. Muraca, Giuseppe Rotondo, F. Civiletti, B. Vizio, O. Bosco, Erica L Martin Conte, G. Frati, L. Delsedime, E. Lupia, V. Fanelli, V. Ranieri   +12 more
semanticscholar   +2 more sources

The Role of Small Interfering RNAs in Hepatocellular Carcinoma

Journal of Gastrointestinal Cancer, 2023
Hepatocellular carcinoma (HCC), a primary liver cancer with high mortality, is the most common malignant tumor in the world. Currently, the effect of routine treatment is poor, especially for this kind of cancer with strong heterogeneity and late detection.
Feng, Chen, Wang, Zhang, Xinran, Gao, Hui, Yuan, Kehai, Liu   +4 more
openaire   +2 more sources

Small Interfering RNAs and RNA Therapeutics in Cardiovascular Diseases

2020
Ribonucleic acid (RNA) is being exploited and understood in its many aspects of function and structure for development of valuable tools in the therapeutics of various diseases such as cardiovascular etc. The expanded knowledge regarding function of RNA in the genomics and inside the cell has dramatically changed the therapeutic strategies in the past ...
Parveen, Bansal, Malika, Arora
openaire   +2 more sources