Results 301 to 310 of about 485,750 (347)
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Oncogene Suppression by Small Interfering RNAs
Current Pharmaceutical Biotechnology, 2004Almost all human cancers have accumulated multiple genetic lesions including oncogenes. It is often unknown whether an oncogene is continuously required for tumorigenesis. Furthermore, it is very difficult to target an essential oncogene with drugs without affecting the corresponding nonmutated protooncogene or related factors.
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Small interfering RNA (siRNA)-based therapeutics
Drug and Therapeutics Bulletin, 2023In early studies in simple organisms and mammalian cell lines, small interfering RNA (siRNA) molecules were found to allow experimental cleavage of intracellular messenger RNA (mRNA; the transcription product of a cell gene), reducing the levels of the proteins that would otherwise be formed by the action of the mRNA, thereby ‘silencing’ a specific ...
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Gene silencing in mammals by small interfering RNAs
Nature Reviews Genetics, 2002Among the 3 billion base pairs of the human genome, there are approximately 30,000-40,000 protein-coding genes, but the function of at least half of them remains unknown. A new tool - short interfering RNAs (siRNAs) - has now been developed for systematically deciphering the functions and interactions of these thousands of genes.
Michael T, McManus, Phillip A, Sharp
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Ribozymes, DNAzymes and Small Interfering RNAs as Therapeutics
Current Drug Targets, 2005Selective gene silencing by nucleic acid enzymes has provided researchers with a new strategy to block gene expression and drug target validation. Ribozymes, DNAzymes and small interfering RNAs (siRNAs) are being explored as genetic inhibitors of gene expression as well as potential therapeutics against viral infections, inflammatory disorders ...
Mouldy, Sioud, Per Ole, Iversen
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A review of nanocarriers for the delivery of small interfering RNA
Biomaterials, 2012Increasing knowledge about molecular mechanisms of endogenous RNA interference (RNAi) and small interfering RNAs (siRNAs) has been incorporated into innovative nucleic acid medicines for treatment of diseases such as cancers. Although RNAi and siRNA have the potential to become powerful therapeutic drugs, their delivery to the target site represents a ...
Prashant, Kesharwani +2 more
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Small Interfering RNA for Effective Cancer Therapies
Mini-Reviews in Medicinal Chemistry, 2011Small interfering RNA (siRNA) has become a specific and powerful tool to turn off the expression of target genes, and has turned into a promising tool in molecular medicine. It can be targeted against cancer by several strategies. These include the suppression of overexpressed oncogenes, retarding cell division by interfering with cyclins and related ...
X, Wang, Y, Chen, J, Ren, X, Qu
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Inhibition of HCV Replication by Small Interfering RNA
2009Small interfering RNAs (siRNAs) and short hairpin RNAs (shRNAs) have been reported to suppress gene expression significantly. HCV seems a suitable candidate for targets of siRNAs, as HCV is a positive single-strand RNA virus and replicates in the cytoplasm.
Ratna B, Ray, Tatsuo, Kanda
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On the delivery of small interfering RNAs into mammalian cells
Expert Opinion on Drug Delivery, 2005RNA interference is becoming the technique of choice for analysing gene function and drug target validation. In this process, sequence-specific gene inhibition is initiated by small RNA duplexes, known as small interfering RNAs (siRNAs). The possibility that exogenously delivered siRNAs or endogenously expressed hairpin siRNAs can cause the destruction
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Derivation and function of small interfering RNAs and microRNAs
Virus Research, 2004Small interfering RNA (siRNA) duplexes are generally produced by Dicer cleavage of double-stranded RNAs of frequently exogenous origin and can induce the cleavage and degradation of mRNAs bearing an identical sequence. In contrast, microRNAs (miRNAs) are encoded within the eukaryotic genome as short RNA hairpin structures.
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Small Interfering RNA in Drug Metabolism and Transport
Current Drug Metabolism, 2007RNA interference (RNAi) is a powerful technique that utilizes RNA molecules to specifically knock down the expression of targeted gene at posttranscriptional level. These small interfering RNAs (siRNAs) not only have broad application to basic biomedical research but may be developed as therapeutic agents.
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