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Oncogene Suppression by Small Interfering RNAs
Current Pharmaceutical Biotechnology, 2004 Almost all human cancers have accumulated multiple genetic lesions including oncogenes. It is often unknown whether an oncogene is continuously required for tumorigenesis. Furthermore, it is very difficult to target an essential oncogene with drugs without affecting the corresponding nonmutated protooncogene or related factors.openaire +3 more sourcesSmall Interfering RNAs and RNA Therapeutics in Cardiovascular Diseases
2020 Ribonucleic acid (RNA) is being exploited and understood in its many aspects of function and structure for development of valuable tools in the therapeutics of various diseases such as cardiovascular etc. The expanded knowledge regarding function of RNA in the genomics and inside the cell has dramatically changed the therapeutic strategies in the past ...Parveen, Bansal, Malika, Aroraopenaire +2 more sourcesEngineering Small Interfering RNAs by Strategic Chemical Modification
2012 Synthetic small interfering RNAs (siRNAs) have revolutionized functional genomics in mammalian cell cultures due to their reliability, efficiency, and ease of use. This success, however, has not fully translated into siRNA applications in vivo and in siRNA therapeutics where initial optimism has been dampened by a lack of efficient delivery strategies ...Bramsen, Jesper Bertram, Kjems, Jørgenopenaire +3 more sourcesTherapeutic potential of small interfering RNAs
Drugs of the Future, 2004 Small interfering RNAs (siRNAs) are emerging as a powerful genetic tool to silence gene expression in a sequence-specific manner. Silencing occurs by the targeted degradation of messenger RNAs, Currently, the technology is used to decipher a large number of biological processes essential for regulating cell differentiation, proliferation and apoptosis. openaire +1 more source[Small interfering RNAs targeting human myostatin].
Molekuliarnaia biologiia, 2010 Ten human myostatin small interfering RNAs which sequence was found by two different software products were synthesized and tested for activity. It was found that three of them have pronounced biological activity and decrease myostatin mRNA level to 22-27% of control value.V A, Furalev, I V, Kravchenko, V O, Popov +2 moreopenaire +1 more sourceSmall Interfering RNA
2010 Michael M. Morgan, MacDonald J. Christie, Luis De Lecea, Jason C. G. Halford, Josee E. Leysen, Warren H. Meck, Catalin V. Buhusi, Marcy J. Bubar, Kathryn A. Cunningham, Marcy J. Bubar, Kathryn A. Cunningham, Richard W. Foltin, David C. S. Roberts, Andreas Marneros, Andreas Marneros, Alex Hofer, Bart Ellenbroek, Christoph U. Correll, Paul Newhouse, Heather Wilkins, Bart Ellenbroek, Joris C. Verster, Emma Childs, Gary Remington, Edoardo Spina, W. Wolfgang Fleischhacker, John Atack, Hilde Lavreysen, David C. S. Roberts, Sheldon Preskorn, Megan M. Dahmen, Jana Lincoln, Dan J. Stein, Anthony L. Riley, Steve Kohut, Angela Roberts, Marilyn E. Carroll, Peter A. Santi, Stefan Leucht, Klaus A. Miczek, David C. S. Roberts, Eileen M. Joyce, Jonathan P. Roiser, Celia J. A. Morgan, Valerie H. Curran, Mary E. Cain, Michael T. Bardo, Terry E. Robinson, Ian Hindmarch, Marilyn E. Carroll, Peter A. Santi, Marcy J. Bubar, Kathryn A. Cunningham, Darrell D. Mousseau, Andrew Holt, Glen B. Baker, Sidney H. Kennedy, Sakina J. Rizvi, Thomas Steckler, Klaus A. Miczek, Seiya Miyamoto, Sakire Pogun, Gorkem Yararbas, Jill B. Becker, Anders Ågmo, Vera Astreika, Robert Segraves, Rodrigo Andrade, Yogita Chudasama, Roshan Cools, Iván Izquierdo, Lia R. Bevilaqua, Martin Cammarota, Bernard Le Foll, Trevor W. Robbins, Husseini K. Manji, Jorge A. Quiroz, Jos Prickaerts, Bart Ellenbroek, Ennio Esposito, William Invernizzi, Sophie Tambour, John C. Crabbe, Peter J. Flor, Inga D. Neumann, Malcolm Lader, Joseph Zohar, Seithikurippu R. Pandi-Perumal, Milton Kramer, Michael J. Thorpy, Shelby Freedman Harris, D. Warren Spence, Gabriele Fischer, Annemarie Unger, Samuel B. Hutton, Huaiyu Yang, George I. Papakostas, S. Kasper, Frank Sams-Dodd, Yavin Shaham, John R. Mantsch, Craig A. Erickson, David J. Posey, Kelly Blankenship, Kimberly A. Stigler, Christopher J. McDougle, Paul D. Callaghan, Iain S. McGregor, Murray R. Thompson, Frank Sams-Dodd, Klaus A. Miczek, Michel Billiard, Brian A. Fallon, Kelli J. Harding, Daniel Hoyer, Jacques Epelbaum, Cécile Viollet, Cécile Viollet, Jacques Epelbaum, Daniel Hoyer, Mischa de Rover, Sander Nieuwenhuis, Trevor W. Robbins, Stan Floresco, Anne Jackson, Mitul A. Mehta, Johannes Mosbacher, Ronald L. Cowan, Robert Kessler, Peter H. Boeijinga, James Winslow, A. Claudio Cuello, Arthur Christopoulos, Gregory D. Stewart, Patrick M. Sexton, Ashwini Padhi, Naomi A. Fineberg, Sidney H. Kennedy, Sakina J. Rizvi, Mark A. Geyer, Francis C. Colpaert, Celia J. A. Morgan, Valerie H. Curran, Andrew Young, Ronald F. Mucha, Craig A. Erickson, David J. Posey, Kelly Blankenship, Kimberly A. Stigler, Christopher J. McDougle, Christof Baltes, Thomas Mueggler, Markus Rudin, Giovanni Hernandez, Peter Shizgal, Marc N. Branch, Ian P. Stolerman, Sharon Morein-Zamir, Barbara J. Sahakian, Yavin Shaham, Sunila G. Nair, Becky Kinkead, Charles B. Nemeroff, Lucy C. Guillory, John R. Mantsch, Yavin Shaham, R. H. De Rijk, E. R. de Kloet, R. H. De Rijk, E. R. de Kloet, Francisco Aboitiz, Ximena Carrasco, F. Xavier Castellanos, Maria Isabel Colado, A. Richard Green, Suzanne H. Mitchell, Harriet de Wit, Alyson J. Bond, Christine A. Franco, Marc N. Potenza, Caroline Cohen, Marc Turiault, Guy Griebel, Darren R. Christensen, Warren K. Bickel, Michael J. Owens, Chase H. Bourke, Gustavo Turecki, Britta Hahn, Britta Hahn, Sarah Morgan, Angus Mackay, Matthew I. Palmatier, Rick A. Bevins, Lawrence Scahill, Andrea Bari, Stephen B. Dunnett, A. Claudio Cuello, Karim Nader, Oliver Hardt +199 moreopenaire +1 more source
