Results 51 to 60 of about 352,358 (326)

Rotavirus gene silencing by small interfering RNAs [PDF]

EMBO reports, 2002
RNA interference is an evolutionarily conserved double‐stranded RNA‐triggered mechanism for suppressing gene expression. Rotaviruses, the leading cause of severe diarrhea in young children, are formed by three concentric layers of protein, from which the spike protein VP4 projects.
Miguel Angel, Déctor, Pedro, Romero, Susana, López, Carlos F, Arias   +3 more
openaire   +2 more sources

Inhibition of hepatitis C virus RNA replication by ISG15 does not require its conjugation to protein substrates by the HERC5 E3 ligase [PDF]

, 2015
Chronic infection of the liver by hepatitis C virus (HCV) induces a range of host factors including IFN-stimulated genes such as ISG15. ISG15 functions as an antiviral factor that limits virus replication. Previous studies have suggested that ISG15 could
Bamford, Connor G.G., Boutell, Chris, Domingues, Patricia, McLauchlan, John   +3 more
core   +2 more sources

Phased secondary small interfering RNAs in Panaxnotoginseng [PDF]

BMC Genomics, 2018
أظهرت النتائج الحديثة أن الجينات غير المشفرة أو الترميز تولد الحمض النووي الريبي الثانوي المتداخل الصغير المرحلي (phasiRNAs) الذي يسترشد بحمض نووي مرئي محدد. حتى الآن، لا توجد دراسات للحمض النووي الريبي الطوري في باناكس نوتوجينسينغ (بورك.) ف.ه. تشين (P. notoginseng)، وهو نوع مهم من النباتات الطبية العشبية الصينية التقليدية.
Kun Chen, Li Liu, Xiaotuo Zhang, Yuanyuan Yuan, Shuchao Ren, Junqiang Guo, Qingyi Wang, Peiran Liao, Shipeng Li, Xiuming Cui, Yongfang Li, Yun Zheng   +11 more
openaire   +3 more sources

Gene silencing in tick cell lines using small interfering or long double-stranded RNA [PDF]

, 2012
Gene silencing by RNA interference (RNAi) is an important research tool in many areas of biology. To effectively harness the power of this technique in order to explore tick functional genomics and tick-microorganism interactions, optimised parameters ...
A-C Barnard, AA Latif, AE Lew-Tabor, Alain Kohl, AM Nijhof, AM Nijhof, CL Donald, DE Brackney, EF Blouin, EM Morazzani, Esther Schnettler, F Jongejan, G Attarzadeh-Yazdi, G Barry, Gerald Barry, GJ Hannon, I Sifuentes-Romero, J Fuente de la, J Fuente de la, J Fuente de la, J Fuente de la, J Fuente de la, JC Clemens, JC Scott, JE George, JH Pedra, John K. Fazakerley, K Kiiver, KM Kocan, L Bell-Sakyi, L Bell-Sakyi, L Bell-Sakyi, L Bell-Sakyi, L Song, Lesley Bell-Sakyi, MGR Varma, P Liljestrom, P Lingor, P Willadsen, Pilar Alberdi, R Fragkoudis, R Fragkoudis, RA Zambon, S Bivalkar-Mehla, S Garcia, S Garcia, S Kurscheid, S Narasimhan, Sabine Weisheit, SM Hammond, SW Ding, TJ Kurtti, TJ Kurtti, UG Munderloh, V Nene, V Shkap, Z Zivkovic, Z Zivkovic   +57 more
core   +4 more sources

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

Clinical Advances of siRNA-Based Nanotherapeutics for Cancer Treatment

Pharmaceutics, 2021
Cancer is associated with single or multiple gene defects. Recently, much research has focused on incorporating genetic materials as one of the means to treat various types of carcinomas.
Dima Hattab, Amirah Mohd Gazzali, Athirah Bakhtiar   +2 more
doaj   +1 more source

The 5' → 3' exoribonuclease XRN1/Pacman and its functions in cellular processes and development [PDF]

, 2012
XRN1 is a 5' → 3' processive exoribonuclease that degrades mRNAs after they have been decapped. It is highly conserved in all eukaryotes, including homologs in Drosophila melanogaster (Pacman), Caenorhabditis elegans (XRN1), and Saccharomyces cerevisiae (
Jones, Christopher Iain, Newbury, Sarah Faith, Zabolotskaya, Maria Vasilyevna   +2 more
core   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Small interfering RNA: potential in real-world clinical practice

Реальная клиническая практика: данные и доказательства
This review describes the basics of protein biosynthesis and RNA interference processes, discusses the useful and unique properties of siRNA therapy, its advantages and disadvantages in comparison with other gene silencing methods, provides a brief ...
A. S. Motrinchuk, A. R. Kasimova
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source