Results 61 to 70 of about 543,226 (367)
Proceedings of the National Academy of Sciences of the United States of America, 2005 Arabidopsis thaliana contains four DICER-LIKE (DCL) genes with specialized functions in small RNA biogenesis for RNA interference-related processes. A mutant with defects in DCL4 was identified and analyzed for microRNA- and endogenous, small interfering
Zhixin Xie +3 more
semanticscholar +1 more source
HEN1 recognizes 21-24 nt small RNA duplexes and deposits a methyl group onto the 2' OH of the 3' terminal nucleotide. [PDF]
, 2006 microRNAs (miRNAs) and small interfering RNAs (siRNAs) in plants bear a methyl group on the ribose of the 3' terminal nucleotide. We showed previously that the methylation of miRNAs and siRNAs requires the protein HEN1 in vivo and that purified HEN1 ...
Chen, Xuemei +3 more
core +2 more sources
Design of Small Interfering RNAs for Antiviral Applications [PDF]
, 2011 RNA interference (RNAi) is an evolutionarily conserved mechanism for sequence-specific target RNA degradation in animals and plants, which plays an essential role in gene regulation. In addition, it is believed to function as a defense against viruses and transposons. In recent years, RNAi has become a widely used approach for studying gene function by
Diana Rothe, Wade Erik, Jens Kurreck
openaire +3 more sources
Oligonucleotide Therapeutics: From Discovery and Development to Patentability
Pharmaceutics, 2022 Following the first proof of concept of using small nucleic acids to modulate gene expression, a long period of maturation led, at the end of the last century, to the first marketing authorization of an oligonucleotide-based therapy.
Lara Moumné +2 more
doaj +1 more source
RNA Interference by Single- and Double-stranded siRNA With a DNA Extension Containing a 3′ Nuclease-resistant Mini-hairpin Structure [PDF]
, 2009 Selective gene silencing by RNA interference (RNAi) involves double-stranded small interfering RNA (ds siRNA) composed of single-stranded (ss) guide and passenger RNAs.
Allison, Simon J., Milner, Jo
core +6 more sources
MicroRNA in control of gene expression: An overview of nuclear functions [PDF]
, 2016 The finding that small non-coding RNAs (ncRNAs) are able to control gene expression in a sequence specific manner has had a massive impact on biology. Recent improvements in high throughput sequencing and computational prediction methods have allowed the
Catalanotto, Caterina +2 more
core +2 more sources
Nucleolar dominance and DNA methylation directed by small interfering RNA [PDF]
, 2008 In the December 5th issue of Molecular Cell, Preuss et al. (2008) demonstrated a link between small interfering RNA (siRNA)-directed de novo DNA methylation and rDNA silencing in nucleolar ...
Finigan, P., Martienssen, R. A.
core +1 more source
Binding of small interfering RNA molecules is crucial for RNA interference suppressor activity of rice hoja blanca virus NS3 in plants [PDF]
, 2009 The NS3 protein of rice hoja blanca tenuivirus represents a viral suppressor of RNAi that sequesters small interfering (si)RNAs in vitro. To determine whether this siRNA binding property is the critical determinant for the suppressor activity of NS3, an ...
Goldbach, R.W. +5 more
core +2 more sources
FEBS Letters, EarlyView.Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke +2 more
wiley +1 more source
HYPERTENSION, 2019 Small interfering RNAs (siRNAs) targeting hepatic angiotensinogen (Agt) may provide long-lasting antihypertensive effects, but the optimal approach remains unclear.
Estrellita Uijl +13 more
semanticscholar +1 more source