Results 71 to 80 of about 777,845 (296)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Vertebrate Natural History Notes from Arkansas, 2017 [PDF]

, 2017
Because meaningful observations of natural history are not always part of larger studies, important pieces of information often are unreported. Small details, however, can fills gaps in understanding and also lead to interesting questions about ...
Buckley, M., Bursey, C. R, Cloutman, D. G, Connior, M. B, Durden, L. A, Fayton, T. J, McAllister, C. T, Robison, H. W, Sasse, D. B, Schratz, S., Tumlison, R.   +10 more
core   +3 more sources

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Virome analysis suggests deltacoronaviruses and picornaviruses as a probable cause of severe intestinal disease on three quail farms

Animal Microbiome
Background Quail farming is increasingly popular mainly due to higher market interest in meat and eggs. However, quails are susceptible to several common poultry viral infections, especially in intensive farming systems.
Urška Kuhar, Uroš Krapež, Brigita Slavec, Joško Račnik, Petra Šenica Kavčič, Urska Jamnikar-Ciglenecki   +5 more
doaj   +1 more source

First Report of Marek’s Disease Virus in Commercial Turkeys in Slovenia

Animals
Marek’s disease (MD), caused by Mardivirus gallidalpha 2 (GaAHV-2), also known as MD virus (MDV), is a lymphoproliferative disease that primarily affects chickens.
Zoran Žlabravec, Brigita Slavec, Ema Rožmanec, Saša Koprivec, Alenka Dovč, Olga Zorman Rojs   +5 more
doaj   +1 more source

Geographic Distribution of Siphonaptera Collected From Small Mammals on Lake Michigan Islands [PDF]

, 2017
The distribution of ten flea species collected from five small mammal host species on 13 Lake Michigan islands is described. Four new eastern and southern records for Hystrichopsylla dippiei Rothschild are given.
Scharf, William C
core   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The grey zone of taxonomy—The case of the Sikkim Myotis (Chiroptera: Vespertilionidae: Myotis sicarius), first recorded from Southeast Asia [PDF]

Vertebrate Zoology
In taxonomic works, the weight to be given to morphological, mitochondrial, or nuclear signals, and the assessment of differences as species or subspecies distinctions has also varied considerably over the past decades and is largely a subjective ...
Dorottya Győrössy, Vuong Tan Tu, Gábor Csorba, Sanjan Thapa, Péter Estók, Gábor Földvári, Tamás Görföl   +6 more
doaj   +3 more sources

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Progressively excluding mammals of different body size affects community and trait structure of ground beetles [PDF]

, 2018
Mammalian grazing induces changes in vegetation properties in grasslands, which can affect a wide variety of other animals including many arthropods. However, the impacts may depend on the type and body size of these mammals.
Risch, Anita C, Schuetz, Martin, Steiner, Magdalena, Vandegehuchte, Martijn L., Wang, Xiaowei   +4 more
core   +2 more sources