Results 161 to 170 of about 194,605 (341)

High-Content Image–Based Screening of a Signal Transduction Pathway Inhibitor Small-Molecule Library against Highly Pathogenic RNA Viruses [PDF]

, 2014
Rajini Mudhasani, Krishna P. Kota, Cary Retterer, Julie P. Tran, Sarah R. Tritsch, Rouzbeh Zamani, Chris A. Whitehouse, Sina Bavari   +7 more
openalex   +1 more source

Screening of DNA-Encoded Small Molecule Libraries inside a Living Cell

, 2021
L. Petersen, Allan Beck Christensen, Jacob Andersen, Charlotta Grånäs, O. Kristensen, Charlotte Uggerhøj Andersen, Amaya Alzu, Frank A. Sløk, Peter Blakskjær, Daniel H. Madsen, Carlos Azevedo, Iolanda Micco, Nils Jakob Vest Hansen   +12 more
openalex   +1 more source

Novel Biologically Active Glass Fiber Functionalized Using Magnesium Phosphate Cement Promotes Bone and Vascular Regeneration

Advanced Biology, EarlyView.
In this study, a new type of bioactive glass fiber ‐based composite magnesium phosphate bone cement is prepared and verified that its mechanical strength and biological properties. In addition, the cement may have played a biologically active role in the Notch and HIF signaling pathways.
Yuzheng Lu, Yanbo Shan, Yingjie Xiong, Jianting Ye, Yanbin Wu, Jipeng Song, Yao Zhang, Wancheng Lin, Haoye Meng, Wenjing Xu, Jiang Peng, Qiang Lu, Lixiang Ding   +12 more
wiley   +1 more source

A Small Molecule Selected from a DNA‐Encoded Library of Natural Products That Binds to TNF‐α and Attenuates Inflammation In Vivo

, 2022
Shuyue Wang, Xiaojie Shi, Jie Li, Qianping Huang, Qun Ji, Ying Yao, Tao Wang, Lili Liu, Min Ye, Yun Deng, Peixiang Ma, Hongtao Xu, Guang Yang   +12 more
openalex   +2 more sources

Consolidate Overview of Ribonucleic Acid Molecular Dynamics: From Molecular Movements to Material Innovations

Advanced Engineering Materials, EarlyView.
Molecular dynamics simulations are advancing the study of ribonucleic acid (RNA) and RNA‐conjugated molecules. These developments include improvements in force fields, long‐timescale dynamics, and coarse‐grained models, addressing limitations and refining methods.
Kanchan Yadav, Iksoo Jang, Jong Bum Lee
wiley   +1 more source

Unbiased high-throughput screening of drug-repurposing libraries identifies small-molecule inhibitors of clot retraction

Blood Advances
: Platelet clot retraction, the ultimate phase of platelet thrombus formation, is critical for clot stabilization. It requires functional αIIbβ3 receptors, fibrin, and the integrated actions of the actin-myosin contractile and cytoskeletal systems ...
Lorena Buitrago, Miriam-Rose Menezes, Chloe Larson, Jihong Li, Thomas Kartika, Priyam Banerjee, Fraser Glickman, Barry Coller   +7 more
doaj  

Translation of DNA into a Library of 13 000 Synthetic Small-Molecule Macrocycles Suitable for in Vitro Selection

, 2008
Brian N. Tse, Thomas M. Snyder, Yinghua Shen, David R. Liu   +3 more
openalex   +1 more source

Multiassay Profiling of a Focused Small Molecule Library Reveals Predictive Bidirectional Modulation of the lncRNA MALAT1 Triplex Stability In Vitro

, 2022
Martina Zafferani, Justin G. Martyr, Dhanasheel Muralidharan, Nadeska I. Montalvan, Zhengguo Cai, Amanda E. Hargrove   +5 more
openalex   +2 more sources

Beyond Order: Perspectives on Leveraging Machine Learning for Disordered Materials

Advanced Engineering Materials, EarlyView.
This article explores how machine learning (ML) revolutionizes the study and design of disordered materials by uncovering hidden patterns, predicting properties, and optimizing multiscale structures. It highlights key advancements, including generative models, graph neural networks, and hybrid ML‐physics methods, addressing challenges like data ...
Hamidreza Yazdani Sarvestani, Surabhi Nadigotti, Erfan Fatehi, Derek Aranguren van Egmond, Behnam Ashrafi   +4 more
wiley   +1 more source

Fluorescent peptide displacement as a general assay for screening small molecule libraries against RNA. [PDF]

Org Biomol Chem, 2019
Patwardhan NN, Cai Z, Newson CN, Hargrove AE.   +3 more
europepmc   +1 more source