Results 191 to 200 of about 194,605 (341)

Machine Learning‐Enabled Polymer Discovery for Enhanced Pulmonary siRNA Delivery

Advanced Functional Materials, EarlyView.
This study provides an efficient approach to train a machine learning model by merging heterogeneous literature data to predict suitable polymers for siRNA delivery. Without the need for extensive laboratory synthesis, the machine learning enabled a virtual screening and successfully predicted a polymer that is validated for effective gene silencing in
Felix Sieber‐Schäfer, Min Jiang, Adrian Kromer, Anny Nguyen, Müge Molbay, Simone Pinto Carneiro, David Jürgens, Gerald Burgstaller, Bastian Popper, Benjamin Winkeljann, Olivia Monika Merkel   +10 more
wiley   +1 more source

A novel algorithm for the virtual screening of extensive small molecule libraries against ERCC1/XPF protein-protein interaction for the identification of resistance-bypassing potential anticancer molecules. [PDF]

Turk J Biol
Ghazy S, Oktay L, Durdaği S.
europepmc   +1 more source

High throughput screening of small molecule libraries for modifiers of radiation responses. [PDF]

Int J Radiat Biol, 2011
Kim K, Damoiseaux R, Norris AJ, Rivina L, Bradley K, Jung ME, Gatti RA, Schiestl RH, McBride WH.   +8 more
europepmc   +1 more source

Versatile Green Transfer of Magnetoelectronics with Loss‐Free Performance and High Adhesion for Interactive Electronics

Advanced Functional Materials, EarlyView.
An environmentally friendly transfer printing method of nm‐thick giant magnetoresistive (GMR) sensors is demonstrated. This method, relying on water and biocompatible polyvinyl alcohol (PVA) polymer without the need of complex treatments, allows transferring thin films to a wide range of biological, organic, and inorganic substrates.
Olha Bezsmertna, Rui Xu, Eduardo Sergio Oliveros Mata, Stanislav Avdoshenko, Clemens Voigt, Sindy Mosch, Mykola Vinnichenko, Denys Makarov   +7 more
wiley   +1 more source

High‐Throughput Microfluidic‐Mediated Assembly of Layer‐By‐Layer Nanoparticles

Advanced Functional Materials, EarlyView.
The layer‐by‐layer (LbL) assembly of polymer films on nanoparticle (NP) surfaces is a promising technique for targeted drug delivery. Despite its success in preclinical mouse models, a current good manufacturing practices (cGMP) compliant, clinical‐scale production method has been lacking.
Ivan S. Pires, Ezra Gordon, Heikyung Suh, Darrell J. Irvine, Paula T. Hammond   +4 more
wiley   +1 more source

Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling. [PDF]

Proc Natl Acad Sci U S A, 2014
Wawer MJ, Li K, Gustafsdottir SM, Ljosa V, Bodycombe NE, Marton MA, Sokolnicki KL, Bray MA, Kemp MM, Winchester E, Taylor B, Grant GB, Hon CS, Duvall JR, Wilson JA, Bittker JA, Dančík V, Narayan R, Subramanian A, Winckler W, Golub TR, Carpenter AE, Shamji AF, Schreiber SL, Clemons PA.   +24 more
europepmc   +1 more source

Rapid Discovery of Functional Small Molecule Ligands against Proteomic Targets through Library-Against-Library Screening

, 2016
Chun‐Yi Wu, Don-Hong Wang, Xiaobing Wang, Seth Dixon, Liping Meng, Sara Ahadi, Daniel Enter, Chao-Yu Chen, Jason Kato, Leonardo J. Leon, Laura M. Ramirez, Yoshiko Maeda, Carolina Fernandes Reis, Brianna Ribeiro, Brittany Weems, Hsing-Jien Kung, Kit S. Lam   +16 more
openalex   +1 more source

Experimentally Validated Design Principles of D‐Block Transition Metal Single‐Atom Non‐Dissociative Chemisorption Solid‐State Hydrogen Storage Materials

Advanced Functional Materials, EarlyView.
A novel descriptor and a bottom‐up design principle are established to enable the rational design of hydrogen storage materials based on d‐block transition metal single‐atom COFs. By modulating H₂ adsorption through d‐orbital tuning, this approach achieves both high storage capacity and fast kinetics, while revealing a volcano‐type relationship between
Qiuyan Yue, Chao Li, Yong Gao, Zhenglong Li, Wen‐Gang Cui, Xinqiang Wang, Guoquan Na, Xiaowei Wang, Yiyang Wan, Mingchang Zhang, Yanxia Liu, Fulai Qi, Chenchen Li, Xu Xue, Jian Miao, Jing Zhang, Xiao Han, Pan Wang, Chang Guo, Xiacui Liu, Mingxia Gao, Wenping Sun, Jian Chen, Zhenhai Xia, Hongge Pan   +24 more
wiley   +1 more source

Longer Acting Injectable: Continuous, Linear Release of a Progestin Contraceptive From an Oxidized Porous Silicon Host

Advanced Healthcare Materials, EarlyView.
Progestin drugs are loaded into a mesoporous silicon dioxide host by melt‐infiltration. Drugs that decompose at or close to their melting point can be loaded by the addition of cholesterol, which acts as a melting point suppressor. High mass loading of the drug is achieved, and dissolution of the composite is controlled by the nanoscale properties of ...
Geoffrey Hollett, Ruhan Fan, Tushar Kumeria, Heidi Leonard, Byungji Kim, Taylor R. Martin, Irmak Ipekci, Joanna Wang, Jiuk Byun, Nicole A. Chan, Amber Pierron, Curtis E. Moore, Jennifer Ayres, Michael J. Sailor   +13 more
wiley   +1 more source

Rod‐shaped Polymerized Salicylic Acid Particles Modulate Neutrophil Transendothelial Migration in Acute Inflammation

Advanced Healthcare Materials, EarlyView.
Rod‐shaped particles outperform spherical particles of the same volume in preventing neutrophil infiltration to inflamed areas, both in vitro and in vivo. This therapeutic effectiveness is attributed to better cell targeting and decreased cell motility, resulting from the geometry‐driven phagocytosis and inhibited actin polymerization.
M. Valentina Guevara, Emma R. Brannon, Daniel Kupor, Mariana R.N. Lima, Logan D. Piegols, Michael L. Felder, Kathryn E. Uhrich, Omolola Eniola‐Adefeso   +7 more
wiley   +1 more source