Results 21 to 30 of about 617,518 (365)

Small-Molecule Positive Allosteric Modulators of theβ₂-Adrenoceptor Isolated from DNA-Encoded Libraries [PDF]

Molecular Pharmacology, 2018
Conventional drug discovery efforts at the β2-adrenoceptor (β2AR) have led to the development of ligands that bind almost exclusively to the receptor’s hormone-binding orthosteric site.
Seungkirl Ahn, Biswaranjan Pani, Alem W. Kahsai, Eva K. Olsen, Gitte Husemoen, M. Vestergaard, Lei Jin, Shuai Zhao, Laura M. Wingler, Paula Rambarat, Rishabh K. Simhal, Thomas T. Xu, Lillian Sun, Paul J. Shim, Dean P. Staus, Li-Yin Huang, Thomas Franch, Xin Chen, Robert J. Lefkowitz   +18 more
openalex   +2 more sources

Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling. [PDF]

Proc Natl Acad Sci U S A, 2014
Wawer MJ, Li K, Gustafsdottir SM, Ljosa V, Bodycombe NE, Marton MA, Sokolnicki KL, Bray MA, Kemp MM, Winchester E, Taylor B, Grant GB, Hon CS, Duvall JR, Wilson JA, Bittker JA, Dančík V, Narayan R, Subramanian A, Winckler W, Golub TR, Carpenter AE, Shamji AF, Schreiber SL, Clemons PA.   +24 more
europepmc   +2 more sources

Recent Advances in Divergent Synthetic Strategies for Indole-Based Natural Product Libraries

Molecules, 2022
Considering the potential bioactivities of natural product and natural product-like compounds with highly complex and diverse structures, the screening of collections and small-molecule libraries for high-throughput screening (HTS) and high-content ...
Taegwan Kim, Min Woo Ha, Jonghoon Kim
doaj   +1 more source

High throughput screening of small molecule libraries for modifiers of radiation responses. [PDF]

Int J Radiat Biol, 2011
Kim K, Damoiseaux R, Norris AJ, Rivina L, Bradley K, Jung ME, Gatti RA, Schiestl RH, McBride WH.   +8 more
europepmc   +2 more sources

Highly parallel translation of DNA sequences into small molecules. [PDF]

PLoS ONE, 2012
A large body of in vitro evolution work establishes the utility of biopolymer libraries comprising 10(10) to 10(15) distinct molecules for the discovery of nanomolar-affinity ligands to proteins.
Rebecca M Weisinger, S Jarrett Wrenn, Pehr B Harbury   +2 more
doaj   +1 more source

Discovery and Validation of a New Class of Small Molecule Toll-Like Receptor 4 (TLR4) Inhibitors [PDF]

, 2013
Many inflammatory diseases may be linked to pathologically elevated signaling via the receptor for lipopolysaccharide (LPS), toll-like receptor 4 (TLR4).
A Afrazi, A Afrazi, A Barochia, AG Rajapakse, Amin Afrazi, Benjamin Eyer, C Kunz, Chhinder P. Sodhi, Christopher J. Guerriero, CL Chen, CL Leaphart, Congrong Ma, CP Sodhi, D Awla, DA Johnson, David J. Hackam, ET Rietschel, F Souza-Fonseca-Guimaraes, FF Yuan, H Carlsen, HM Kim, Hongpeng Jia, J Neu, Jeffrey L. Brodsky, John Ozolek, KH Lee, KR Bortoluci, L Bode, L Bode, L Bode, M Ciszewicz, M Good, M Pierer, Maria Branca, Matthew D. Neal, MD Neal, Misty Good, MM Fort, Peter Wipf, R Medzhitov, S Sakai, S Sanlioglu, Samithamby Jeyaseelan, SC Gribar, T Jilling, Thomas Prindle, WK den Dekker, WM Richardson   +47 more
core   +9 more sources

Bloom filters for molecules

Journal of Cheminformatics, 2023
Ultra-large chemical libraries are reaching 10s to 100s of billions of molecules. A challenge for these libraries is to efficiently check if a proposed molecule is present. Here we propose and study Bloom filters for testing if a molecule is present in a
Jorge Medina, Andrew D. White
doaj   +1 more source

High-content analysis of proapoptotic EphA4 dependence receptor functions using small-molecule libraries. [PDF]

J Biomol Screen, 2012
Small-molecule compounds (SMCs) can provide an inexpensive and selective approach to modifying biological responses. High-content analysis (HCA) of SMC libraries can help identify candidate molecules that inhibit or activate cellular responses.
Nelersa CM, Barreras H, Runko E, Ricard J, Shi Y, Glass SJ, Bixby JL, Lemmon VP, Liebl DJ.   +8 more
europepmc   +2 more sources

Directed Chemical Evolution with an Outsized Genetic Code. [PDF]

PLoS ONE, 2016
The first demonstration that macromolecules could be evolved in a test tube was reported twenty-five years ago. That breakthrough meant that billions of years of chance discovery and refinement could be compressed into a few weeks, and provided a ...
Casey J Krusemark, Nicolas P Tilmans, Patrick O Brown, Pehr B Harbury   +3 more
doaj   +1 more source

Construction of a synthetic methodology-based library and its application in identifying a GIT/PIX protein–protein interaction inhibitor

Nature Communications, 2022
Chemical libraries with skeleton diversity are important for drug discovery. Here, the authors establish a synthetic methodology-based compound library (SMBL), and apply it to identify a small-molecule inhibitor to interrupt a challenging target:  the ...
Jing Gu, Rui-Kun Peng, Chun-Ling Guo, Meng Zhang, Jie Yang, Xiao Yan, Qian Zhou, Hongwei Li, Na Wang, Jinwei Zhu, Qin Ouyang   +10 more
doaj   +1 more source