Results 21 to 30 of about 198,939 (338)
Directed Chemical Evolution with an Outsized Genetic Code. [PDF]
PLoS ONE, 2016 The first demonstration that macromolecules could be evolved in a test tube was reported twenty-five years ago. That breakthrough meant that billions of years of chance discovery and refinement could be compressed into a few weeks, and provided a ...
Casey J Krusemark +3 more
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Nature Communications, 2022 Chemical libraries with skeleton diversity are important for drug discovery. Here, the authors establish a synthetic methodology-based compound library (SMBL), and apply it to identify a small-molecule inhibitor to interrupt a challenging target: the ...
Jing Gu +10 more
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Impact of DNA-Encoded Chemical Library Technology on Drug Discovery
CHIMIA, 2022 DNA-Encoded Chemical Libraries (DELs) have gained momentum over the recent years for the discovery of small-molecule ligands and the technology has been integrated in most of the larger pharmaceutical companies.
Michelle Keller +2 more
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NeuralDock: Rapid and Conformation-Agnostic Docking of Small Molecules
Frontiers in Molecular Biosciences, 2022 Virtual screening is a cost- and time-effective alternative to traditional high-throughput screening in the drug discovery process. Both virtual screening approaches, structure-based molecular docking and ligand-based cheminformatics, suffer from ...
Congzhou M. Sha +6 more
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Química Nova, 2001 Combinatorial Chemistry has become a very efficient methodology in drug research. Recent progress in combinatorial synthesis performed both in solid and solution phase have led to a change in the paradigm for the identification and optimization of lead ...
Ricardo L. Araújo Dias +1 more
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Frontiers in Pharmacology, 2023 Virtual small molecule libraries are valuable resources for identifying bioactive compounds in virtual screening campaigns and improving the quality of libraries in terms of physicochemical properties, complexity, and structural diversity.
Fernanda I. Saldívar-González +2 more
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Plant chemical genetics : from phenotype-based screens to synthetic biology [PDF]
, 2017 The treatment of a biological system with small molecules to specifically perturb cellular functions is commonly referred to as chemical biology. Small molecules are used commercially as drugs, herbicides, and fungicides in different systems, but in ...
Dejonghe, Wim, Russinova, Eugenia
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Identification of novel small molecule inhibitors of adenovirus gene transfer using a high throughput screening approach [PDF]
, 2013 Due to many favourable attributes adenoviruses (Ads) are the most extensively used vectors for clinical gene therapy applications. However, following intravascular administration, the safety and efficacy of Ad vectors are hampered by the strong hepatic ...
Alan L. Parker +36 more
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Stem Cells Translational Medicine, 2020 Identification of small molecules with the potential to selectively proliferate cardiac progenitor cells (CPCs) will aid our understanding of the signaling pathways and mechanisms involved and could ultimately provide tools for regenerative therapies for
Lauren Drowley +14 more
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Elimination of PCR duplicates in RNA-seq and small RNA-seq using unique molecular identifiers
BMC Genomics, 2018 Background RNA-seq and small RNA-seq are powerful, quantitative tools to study gene regulation and function. Common high-throughput sequencing methods rely on polymerase chain reaction (PCR) to expand the starting material, but not every molecule ...
Yu Fu +4 more
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