Results 21 to 30 of about 645,880 (357)

Inkjet Bioprinting on Parchment Paper for Hit Identification from Small Molecule Libraries [PDF]

ACS Omega, 2019
Jungmi Lee, Baskaran Purushothaman, Joon Myong Song   +2 more
doaj   +2 more sources

Selecting, Acquiring, and Using Small Molecule Libraries for High-Throughput Screening. [PDF]

Curr Protoc Chem Biol, 2012
Dandapani S, Rosse G, Southall N, Salvino JM, Thomas CJ.   +4 more
europepmc   +2 more sources

Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling. [PDF]

Proc Natl Acad Sci U S A, 2014
Wawer MJ, Li K, Gustafsdottir SM, Ljosa V, Bodycombe NE, Marton MA, Sokolnicki KL, Bray MA, Kemp MM, Winchester E, Taylor B, Grant GB, Hon CS, Duvall JR, Wilson JA, Bittker JA, Dančík V, Narayan R, Subramanian A, Winckler W, Golub TR, Carpenter AE, Shamji AF, Schreiber SL, Clemons PA.   +24 more
europepmc   +2 more sources

High throughput screening of small molecule libraries for modifiers of radiation responses. [PDF]

Int J Radiat Biol, 2011
Kim K, Damoiseaux R, Norris AJ, Rivina L, Bradley K, Jung ME, Gatti RA, Schiestl RH, McBride WH.   +8 more
europepmc   +2 more sources

Recent Advances in Divergent Synthetic Strategies for Indole-Based Natural Product Libraries

Molecules, 2022
Considering the potential bioactivities of natural product and natural product-like compounds with highly complex and diverse structures, the screening of collections and small-molecule libraries for high-throughput screening (HTS) and high-content ...
Taegwan Kim, Min Woo Ha, Jonghoon Kim
doaj   +1 more source

Screening of DNA-Encoded Small Molecule Libraries inside a Living Cell.

Journal of the American Chemical Society, 2021
DNA-encoded small molecule libraries (DELs) have facilitated the discovery of novel modulators of many different therapeutic protein targets. We report the first successful screening of a multimillion membered DEL inside a living cell.
L. Petersen, A. Christensen, Jacob Andersen, Charlotta G Folkesson, O. Kristensen, Charlotte Andersen, Amaya Alzu, F. Sløk, P. Blakskjær, Daniel Madsen, Carlos Azevedo, Iolanda Micco, N. Hansen   +12 more
semanticscholar   +1 more source

Highly parallel translation of DNA sequences into small molecules. [PDF]

PLoS ONE, 2012
A large body of in vitro evolution work establishes the utility of biopolymer libraries comprising 10(10) to 10(15) distinct molecules for the discovery of nanomolar-affinity ligands to proteins.
Rebecca M Weisinger, S Jarrett Wrenn, Pehr B Harbury   +2 more
doaj   +1 more source

Bloom filters for molecules

Journal of Cheminformatics, 2023
Ultra-large chemical libraries are reaching 10s to 100s of billions of molecules. A challenge for these libraries is to efficiently check if a proposed molecule is present. Here we propose and study Bloom filters for testing if a molecule is present in a
Jorge Medina, Andrew D. White
doaj   +1 more source

Directed Chemical Evolution with an Outsized Genetic Code. [PDF]

PLoS ONE, 2016
The first demonstration that macromolecules could be evolved in a test tube was reported twenty-five years ago. That breakthrough meant that billions of years of chance discovery and refinement could be compressed into a few weeks, and provided a ...
Casey J Krusemark, Nicolas P Tilmans, Patrick O Brown, Pehr B Harbury   +3 more
doaj   +1 more source

Construction of a synthetic methodology-based library and its application in identifying a GIT/PIX protein–protein interaction inhibitor

Nature Communications, 2022
Chemical libraries with skeleton diversity are important for drug discovery. Here, the authors establish a synthetic methodology-based compound library (SMBL), and apply it to identify a small-molecule inhibitor to interrupt a challenging target:  the ...
Jing Gu, Rui-Kun Peng, Chun-Ling Guo, Meng Zhang, Jie Yang, Xiao Yan, Qian Zhou, Hongwei Li, Na Wang, Jinwei Zhu, Qin Ouyang   +10 more
doaj   +1 more source