Results 91 to 100 of about 442,180 (329)

Subpar reporting of pre‐analytical variables in RNA‐focused blood plasma studies

Molecular Oncology, EarlyView.
Pre‐analytical variables strongly influence the analysis of extracellular RNA (cell‐free RNA; exRNA) derived from blood plasma. Their reporting is essential to allow interpretation and replication of results. By evaluating 200 exRNA studies, we pinpoint a lack of reporting pre‐analytical variables associated with blood collection, plasma preparation ...
Céleste Van Der Schueren, Philippe Decruyenaere, Francisco Avila Cobos, Johanna Bult, Jill Deleu, Laudonia Lidia Dipalo, Hetty Hilde Helsmoortel, Eva Hulstaert, Annelien Morlion, Elena Ramos Varas, Kathleen Schoofs, Wim Trypsteen, Eveline Vanden Eynde, Hanne Van Droogenbroeck, Kimberly Verniers, Jo Vandesompele, Anneleen Decock   +16 more
wiley   +1 more source

Yeast Rrp8p, a novel methyltransferase responsible for m1A 645 base modification of 25S rRNA [PDF]

, 2012
Ribosomal RNA undergoes various modifications to optimize ribosomal structure and expand the topological potential of RNA. The most common nucleotide modifications in ribosomal RNA (rRNA) are pseudouridylations and 2'-O methylations (Nm), performed by H ...
Entian, Karl-Dieter, Kötter, Peter, Lamberth, Stefanie, Peifer, Christian, Sharma, Sunny, Watzinger, Peter   +5 more
core   +1 more source

Small nucleolar RNA signatures as biomarkers for non-small-cell lung cancer

Molecular Cancer, 2010
Background Non-small-cell lung cancer (NSCLC) is the leading cause of cancer death. Early detection of NSCLC will improve its outcome. The current techniques for NSCLC early detection are either invasive or have low accuracy.
Li Ruiyun, Shen Jun, Guarnera Maria, Mei Yuping, Yu Lei, Liao Jipei, Liu Zhenqiu, Jiang Feng   +7 more
doaj   +1 more source

The Prognostic Value of Expression of the Long Noncoding RNA (lncRNA) Small Nucleolar RNA Host Gene 1 (SNHG1) in Patients with Solid Malignant Tumors: A Systematic Review and Meta-Analysis

Medical Science Monitor, 2018
Background The long non-coding RNA (lncRNA) small nucleolar RNA host gene 1 (SNHG1) is expressed in solid malignant tumors. The aim of this systematic review and meta-analysis was to determine whether expression of the lncRNA SNHG1 was associated with ...
Bufan Xiao, Zhaohao Huang, Ruihao Zhou, Jingtao Zhang, Bentong Yu   +4 more
semanticscholar   +1 more source

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source

The effect of RNA stiffness on the self-assembly of virus particles [PDF]

, 2018
Under many in vitro conditions, some small viruses spontaneously encapsidate a single stranded (ss) RNA into a protein shell called the capsid. While viral RNAs are found to be compact and highly branched because of long distance base-pairing between nucleotides, recent experiments reveal that in a head-to-head competition between a ssRNA with no ...
arxiv   +1 more source

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

Regulatory Role of Small Nucleolar RNAs in Human Diseases [PDF]

BioMed Research International, 2015
Small nucleolar RNAs (snoRNAs) are appreciable players in gene expression regulation in human cells. The canonical function of box C/D and box H/ACA snoRNAs is posttranscriptional modification of ribosomal RNAs (rRNAs), namely, 2′-O-methylation and pseudouridylation, respectively.
Julia A. Filippova, G. A. Stepanov, Dmitry V. Semenov, Elena V. Kuligina, Andrey Komissarov, Vladimir A. Richter   +5 more
openaire   +3 more sources

Telomere disruption results in non-random formation of de novo dicentric chromosomes involving acrocentric human chromosomes [PDF]

, 2010
Copyright: © 2010 Stimpson et al.Genome rearrangement often produces chromosomes with two centromeres (dicentrics) that are inherently unstable because of bridge formation and breakage during cell division. However, mammalian dicentrics, and particularly
A Henderson, A Hill, A Krystosek, A Smogorzewska, AH Sturtevant, AK Sinha, AL Lam, Anna Jauch, AW Higgins, AW Higgins, AW Lo, B McClintock, B van Steensel, BA Sullivan, BA Sullivan, BA Sullivan, BA Sullivan, BA Sullivan, BE Black, BE Black, Beth A. Sullivan, C Mann, C Pondarre, C Shiels, C Tyler-Smith, CH Gravholt, D Granick, D Hanahan, D Koshland, DJ Wolff, DK Palmer, DK Palmer, DR Foltz, DR Foltz, E Novitski, E Therman, EM Dunleavy, F Han, F Mitelman, F Mitelman, F Mitelman, GB Celli, GM Greig, Gregory P. Copenhaver, HE Trowell, Heidi Holtgreve-Grez, HF Willard, Ihn Young Song, J Hamerton, J Karlseder, J Karlseder, J Lange, J Pampalona, J Waye, JA Brock, JA Croft, JA Evans, JA Hackett, JE Sylvester, JJ Roix, JM Bridger, JM Craig, JM Spence, Joanna M. Bridger, K Ahmad, K Bross, K Mizuno, Kaitlin M. Stimpson, Karen E. Hayden, KH Choo, M Krzywinski, MD Blower, MD Blower, MG Schueler, MJ Ramirez, MR Branco, MR Lowden, NC Steiner, P Maraschio, PB Vagnarelli, PE Warburton, PE Warburton, S Cardinale, S Schwartz, S Spadari, S Zhang, SF Louis, SL Page, T Dousset, T Haaf, T Hori, TC Hsu, W Robertson, WC Earnshaw, WC Earnshaw, XY Guan, YZ Zheng   +96 more
core   +4 more sources

Small RNA sequencing reveals distinct nuclear microRNAs in pig granulosa cells during ovarian follicle growth

Journal of Ovarian Research, 2021
Nuclear small RNAs have emerged as an important subset of non-coding RNA species that are capable of regulating gene expression. A type of small RNA, microRNA (miRNA) have been shown to regulate development of the ovarian follicle via canonical targeting
Derek Toms, Bo Pan, Yinshan Bai, Julang Li   +3 more
doaj   +1 more source