Results 91 to 100 of about 202,981 (234)

The IC-SNURF-SNRPN transcript serves as a host for multiple small nucleolar RNA species and as an antisense RNA for UBE3A.

Human Molecular Genetics, 2001
The imprinted domain on human chromosome 15 consists of two oppositely imprinted gene clusters, which are under the coordinated control of an imprinting center (IC) at the 5' end of the SNURF-SNRPN gene.
M. Runte, A. Hüttenhofer, S. Gross, M. Kiefmann, B. Horsthemke, K. Buiting   +5 more
semanticscholar   +1 more source

A cellular model of TDP‐43 induces phosphorylated TDP‐43 aggregation with distinct changes in solubility and autophagy dysregulation

The FEBS Journal, EarlyView.
TDP‐43 protein plays a pathological role in sporadic and familial amyotrophic lateral sclerosis (ALS). Here, we developed a cellular model overexpressing TDP‐43 with three mutations linked to familial ALS, termed ‘3X‐TDP‐43’. Mutant 3X‐TDP‐43 expression showed deficits in autophagy flux and colocalization with stress granules.
Matthew B. Dopler, Muhammad I. Abeer, Sanaz Arezoumandan, Keyshawn Cox, Tyler L. Petersen, Esther H. Daniel, Carlton L. Cannon III, Angelica Bautista, Kennedy D. Blancher, Alysia M. Bland, Kylie J. Bond, Dominque A. Davis, Jessica M. Francois, Eliana J. McCray, Justin M. Morgan, Jessica L. Pulliam, Zymir A. Robinson, Mykia J. Taylor, James A. Dowell, Nigel J. Cairns, Michael A. Gitcho   +20 more
wiley   +1 more source

Small nucleolar RNA 113–1 suppresses tumorigenesis in hepatocellular carcinoma

Molecular Cancer, 2014
BackgroundEmerging evidence suggests that small nucleolar RNAs (snoRNAs) are involved in tumorigenesis. The roles of small nucleolar RNA 113–1 (SNORD113-1) on the development of hepatocellular carcinoma (HCC) remain unknown.MethodsThe expression of ...
Gang Xu, Fang Yang, Cuiling Ding, Lan‐juan Zhao, H. Ren, P. Zhao, Wen Wang, Z. Qi   +7 more
semanticscholar   +1 more source

Interaction of TFAP2A with the Ku70/80 complex is crucial for HIF‐dependent activation of hypoxia‐inducible genes

The FEBS Journal, EarlyView.
Under normoxic conditions, the SUMOylated fraction of TFAP2A cannot interact with the Ku70/Ku80 complex, nor it can bind to chromatin. The unSUMOylated fraction pre‐occupies the chromatin of a subset of hypoxia‐induced genes together with the Ku70/Ku80 complex for basal euchromatin formation. Under hypoxic conditions, the SUMOylation equilibrium shifts
Amalia Kanoura, Antonis Giakountis, Chrysa Filippopoulou, Angeliki Karagiota, George Stamatakis, Martina Samiotaki, George Panayotou, George Simos, Georgia Chachami   +8 more
wiley   +1 more source

RNA and Proteins: Mutual Respect [version 1; referees: 3 approved]

F1000Research, 2017
Proteins and RNA are often found in ribonucleoprotein particles (RNPs), where they function in cellular processes to synthesize proteins (the ribosome), chemically modify RNAs (small nucleolar RNPs), splice pre-mRNAs (the spliceosome), and, on a larger ...
Kathleen B. Hall
doaj   +1 more source

Stress alters hypothalamic gene expression in adolescent male Golden hamsters

Journal of Neuroendocrinology, EarlyView.
Abstract In Golden hamsters (Mesocricetus auratus), a two‐week exposure to chronic social stress in adolescence causes acceleration of agonistic behavior, enhanced adult aggression, impaired waiting impulsivity, and higher food intake, body fat, and long‐term increased body weight.
Kevin M. Moran, Tyler M. Milewski, James P. Curley, Yvon Delville   +3 more
wiley   +1 more source

Circulating pancreatic cancer exosomal RNAs for detection of pancreatic cancer

Molecular Oncology, 2019
Diagnostic biomarkers for the early diagnosis of pancreatic cancer are needed to improve prognosis for this disease. The aim of this study was to investigate differences in the expression of four messenger RNAs (mRNAs: CCDC88A, ARF6, Vav3, and WASF2) and
Tatsuya Kitagawa, Keisuke Taniuchi, Makiko Tsuboi, Masahiko Sakaguchi, Takuhiro Kohsaki, Takehiro Okabayashi, Toshiji Saibara   +6 more
doaj   +1 more source

White paper on best practices for translational research in neuroendocrine neoplasms

Journal of Neuroendocrinology, EarlyView.
Abstract Basic and translational investigations play a crucial role in advancing our understanding of neuroendocrine neoplasms (NENs). In this white paper by the Basic and Translational Research Group of the European Neuroendocrine Tumor Society, we discuss the qualities and drawbacks of current disease models and propose good practices for integrating
Jerome Cros, Oriol Casanovas, Justo P. Castaño, Talya Dayton, Alejandro Garcia Alvarez, Benjamin Gibert, Michele Simbolo, Timon Vandamme, Mauro Cives, Ilaria Marinoni, on behalf of the ENETS Basic and Translational Research Group (BTRG)   +10 more
wiley   +1 more source

Plant small nuclear RNAs. Nucleolar U3 snRNA is present in plants: partial characterization [PDF]

, 1985
Tamás Kiss, Márta Tóth, Ferenc Solymosy   +2 more
openalex   +1 more source

An Australian chickpea pan‐genome provides insights into genome organization and offers opportunities for enhancing drought adaptation for crop improvement

Plant Biotechnology Journal, EarlyView.
Summary Chickpea (Cicer arietinum L.) is an important legume crop that has been subjected to intensive breeding, resulting in limited genetic diversity. Australia is the world's second largest producer and the leading exporter of chickpea; the genomic architecture of its cultivars remains largely unexplored.
Vanika Garg, Rutwik Barmukh, Yan Huang, Annapurna Chitikineni, Kristy Hobson, Bicheng Yang, Yong Jia, Shengnan Bi, Sukhjiwan Kaur, Muhammad Ahsan Asif, Matthew Hayden, Sally Norton, Darshan L. Sharma, Kadambot H. M. Siddique, Xin Liu, Chengdao Li, Rajeev K. Varshney   +16 more
wiley   +1 more source