Results 71 to 80 of about 37,390 (195)

Regulatory Role of Small Nucleolar RNAs in Human Diseases [PDF]

BioMed Research International, 2015
Small nucleolar RNAs (snoRNAs) are appreciable players in gene expression regulation in human cells. The canonical function of box C/D and box H/ACA snoRNAs is posttranscriptional modification of ribosomal RNAs (rRNAs), namely, 2′-O-methylation and pseudouridylation, respectively.
Stepanov, Grigory A., Filippova, Julia A., Komissarov, Andrey B., Kuligina, Elena V., Richter, Vladimir A., Semenov, Dmitry V.   +5 more
openaire   +2 more sources

Expression of small nucleolar RNAs in leukemic cells

Cellular Oncology, 2012
Small nucleolar RNAs (snoRNAs) direct sequence-specific modifications to ribosomal RNA. We hypothesized that the expression of snoRNAs may be altered in leukemic cells.The expression of snoRNAs was analyzed in various leukemic cell lines by massive parallel sequencing (SOLiD).
Uusimäki Annemari, Teittinen Kaisa, Lohi Olli, Lohi Olli, Laiho Asta Suvi Tuulikki, Gyenesei Attila, Pursiheimo Juha-Pekka   +6 more
openaire   +2 more sources

Vaginal host–microbe signatures linked to placental outcomes in mares

Equine Veterinary Journal, EarlyView.
Abstract Background Ascending placentitis is a leading cause of late‐term pregnancy loss in mares. Although pathogens are presumed to ascend from the caudal reproductive tract, the association between the vaginal microbiome and placentitis has not been systematically examined.
Machteld van Heule, Babiche Heil, Jamie K. Norris, Kristene Gedye, Xiaoxiao Lin, Ward De Spiegelaere, Peter Daels, Pouya Dini   +7 more
wiley   +1 more source

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source

Proteomic Analysis of Mixed Cell Membrane Extracts From Triple‐Negative Breast Cancer Cell Lines Revealed Broad Metabolic Reprogramming Associated With Tumor Progression

PROTEOMICS, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) represents the most aggressive subtype with limited therapeutic options and the poorest clinical outcomes. Using high‐resolution nUPLC‐QTOF‐MS/MS, we performed comprehensive proteomic profiling of TNBC cell lines representing disease progression stages: HCC‐1937 (stage IIB), HCC‐1599 (stage IIIA), and MDA ...
Claudia Sissely Chaviano‐Montes de Oca, Violeta Larios‐Serrato, María Luisa Labra‐Barrios, Emmanuel Ríos‐Castro, Carlos Alberto Castañón‐Sánchez, Rodolfo Moreno‐Castillo, Erika Beatriz Ángeles‐Morales, Juan Pedro Luna‐Arias   +7 more
wiley   +1 more source

Carbon dots in electrochemiluminescence: Mechanisms, interface engineering, and bioanalytical applications

Responsive Materials, EarlyView.
Carbon dots are emerging as versatile electrochemiluminescent nanomaterials whose structure, surface states, and interfacial design jointly determine ECL pathways and performance. This review highlights how mechanistic understanding and materials engineering enable programmable CD‐ECL systems for bioanalysis, imaging, and future intelligent analytical ...
Yuhan Zhao, Zixuan Chen, Jun‐Jie Zhu
wiley   +1 more source

P,N,S‐Co‐Doped Red‐Emissive Carbon Dots for Microenvironment‐Sensitive Organelle Imaging and Monitoring Cellular Redox Processes

Small, EarlyView.
Phosphorus‐, nitrogen‐, and sulfur‐co‐doped red‐emissive carbon dots (PNS‐R‐CDs) enable ON–OFF–ON ClO−/GSH redox sensing and microenvironment‐responsive subnuclear imaging, providing a versatile fluorescent nanoplatform for monitoring localized oxidative stress and intracellular heterogeneity.
Amanda Ana Pinheiro, Chetan Gajanan Tathe, Richa Garg, Chayan Kanti Nandi, Mainak Banerjee, Amrita Chatterjee   +5 more
wiley   +1 more source

Long non‐coding small nucleolar RNA host genes in digestive cancers

Cancer Medicine, 2019
Although long noncoding RNAs (lncRNAs) do not have protein coding capacities, they are involved in the pathogenesis of many types of cancers, including hepatocellular carcinoma, cervical cancer, and gastric cancer. Notably, the roles of lncRNAs are vital
Huan Yang, Zheng Jiang, Shuang Wang, Yongbing Zhao, Xiaomei Song, Yufeng Xiao, Shiming Yang   +6 more
doaj   +1 more source

LINC00892 inhibits hepatocellular carcinoma progression through SBDS/EIF6‐mediated ribosomal stress and interacting with the immune microenvironment

VIEW, EarlyView.
LINC00892 is lowly expressed in HCC. LINC00892 overexpression induces ribosomal stress via inhibiting SBDS, restrains EIF6 nuclear translocation and activates p53 pathway. LINC00892 overexpression and p53 activation jointly suppress HCC progression. High LINC00892 is associted with infiltration of CD8+ T cells, B cells and macrophages, and associated ...
Xu Zhang, Lina Ma, Juan Ma, Long Hai, Lina Wu, Xueyan Feng, Xiangchun Ding   +6 more
wiley   +1 more source

The circadian dynamics of small nucleolar RNA [PDF]

, 2017
Abstract The circadian regulation of gene expression allows plants and animals to anticipate predictable environmental changes. While the influence of the circadian clock has recently been shown to extend to ribosome biogenesis, the dynamics and regulation of the many small nucleolar RNA that are required in pre-ribosomal RNA folding ...
Aitken, Stuart, Semple, Colin A.
openaire   +1 more source