Results 61 to 70 of about 37,390 (195)

Folate-driven changes in snoRNA function: a novel epigenetic-ribosomal axis in hepatocellular carcinoma

Hereditas
Folate (FA), essential for DNA synthesis, repair and methylation, is predominantly stored and metabolized in the liver. Dysregulation of folate intake and metabolism is strongly implicated in the pathogenesis of hepatocellular carcinoma (HCC).
Xinxin Song, Deyu Kong, Yongjiao Zi, Xu Wang, Juan Ni   +4 more
doaj   +1 more source

Molecular Mechanisms and Clinical Implications of Noncoding RNAs in Cancer

Non-Coding RNA
Noncoding RNAs (ncRNAs), which include small nuclear RNAs (snRNAs), small nucleolar RNAs (snoRNAs), microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs), are RNA molecules that arise from genomic regions without protein-coding ...
Jin Wang, Xiaomeng He, Christopher Corpe
doaj   +1 more source

FTSJ3‐Mediated 2′‐O‐Methylation of HSPA5 mRNA Stabilizes BOP1 via SUMOylation to Drive DRP1‐Dependent Mitochondrial Fission and Fatty Acid Oxidation in Lung Squamous Cell Carcinoma

Advanced Science, EarlyView.
The RNA methyltransferase FTSJ3 drives lung squamous cell carcinoma progression by catalyzing 2′‐O‐methylation of HSPA5 mRNA, which stabilizes BOP1 through SUMOylation and activates DRP1/SREBP1‐mediated mitochondrial fission and fatty acid oxidation. Targeting this axis with liposomal siRNA potently suppresses tumor growth and metastasis ABSTRACT Lung ...
Qin Hu, Jiaheng Lin, Yifei Zhu, Ying Liu, Guoren Zhou   +4 more
wiley   +1 more source

Small RNA sequencing reveals distinct nuclear microRNAs in pig granulosa cells during ovarian follicle growth

Journal of Ovarian Research, 2021
Nuclear small RNAs have emerged as an important subset of non-coding RNA species that are capable of regulating gene expression. A type of small RNA, microRNA (miRNA) have been shown to regulate development of the ovarian follicle via canonical targeting
Derek Toms, Bo Pan, Yinshan Bai, Julang Li   +3 more
doaj   +1 more source

Decoding Biomolecular Phase Separation: From Physiological Roles to Pathological Mechanisms and Therapeutic Biomaterials Design

Advanced Science, EarlyView.
This review systematically elaborates on the mechanisms underlying physiological regulation and pathological dysregulation of biomolecular phase separation. It also summarizes advances in phase‑separation‑targeted therapeutic strategies and the design of functional biomaterials inspired by this process.
Jiawei Zhu, Jingbo Dong, Qiufang Gong, Xuejiao Song, Zhifa Shen, Chao Liang   +5 more
wiley   +1 more source

Changes to small RNA expression in macrophages in response to very low-density lipoprotein lipid hydrolysis by lipoprotein lipase and NADPH oxidase inhibition

BMC Research Notes
Objective We previously reported that hydrolysis products (HP) generated from total lipoproteins via lipoprotein lipase (LPL) significantly changed the transcriptome of human macrophages, including an increased representation of small nucleolar RNAs, but
Mariam O. Tijani, Elizabeth W. Chia, Natalie S. M. Cotter, Lourdes Peña-Castillo, Robert J. Brown   +4 more
doaj   +1 more source

Aortic valve disease: Novel animal models for advancing our understanding of the underlying mechanisms

Animal Models and Experimental Medicine, EarlyView.
Due to the complex pathophysiology of aortic valve disease (AVD) and the resulting lack of effective pharmacotherapy, existing animal models are valuable research tools, but each has its own strengths and limitations. This review systematically surveys the major AVD models, compares their induction methods, pathological features, advantages and ...
Liya Hou, Xue Liu, Wangxing Hu, Xianbao Liu, Wei Zhu   +4 more
wiley   +1 more source

Mapping targets for small nucleolar RNAs in yeast

Wellcome Open Research, 2018
Background: Recent analyses implicate changes in the expression of the box C/D class of small nucleolar RNAs (snoRNAs) in several human diseases. Methods: Here we report the identification of potential novel RNA targets for box C/D ...
Tatiana Dudnakova, Hywel Dunn-Davies, Rosie Peters, David Tollervey   +3 more
openaire   +3 more sources

Nucleolar Localization Elements ofXenopus laevisU3 Small Nucleolar RNA [PDF]

Molecular Biology of the Cell, 1998
The Nucleolar Localization Elements (NoLEs) of Xenopus laevis U3 small nucleolar RNA (snoRNA) have been defined. Fluorescein-labeled wild-type U3 snoRNA injected intoXenopus oocyte nuclei localized specifically to nucleoli as shown by fluorescence microscopy. Injection of mutated U3 snoRNA revealed that the 5′ region containing Boxes A and A′, known to
T S, Lange, M, Ezrokhi, A V, Borovjagin, R, Rivera-León, M T, North, S A, Gerbi   +5 more
openaire   +2 more sources

Small nucleolar RNAs signature (SNORS) identified clinical outcome and prognosis of bladder cancer (BLCA)

Cancer Cell International, 2020
Background Small nucleolar RNAs (snoRNAs) are a new non-coding RNAs (ncRNAs), which have not been widely investigated and are identified to be involved in tumorigenesis. But the function of snoRNAs in BLCA has not been reported yet.
Rui Cao, Bo Ma, Lushun Yuan, Gang Wang, Ye Tian   +4 more
doaj   +1 more source