Results 91 to 100 of about 37,390 (195)

Single‐Cell Transcriptomic Identification of Drug‐Tolerant Persister Mechanisms in Capecitabine‐Treated Triple‐Negative Breast Cancer

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Triple‐negative breast cancer (TNBC) is an aggressive subtype defined by the absence of estrogen receptor (ER), progesterone receptor (PR), and HER2 expression. This lack of receptors limits targeted therapies and contributes to high rates of recurrence.
Md Naiyem Islam, Md Kaziul Islam Sarkar Suja, Alif Al Takbir, Md. Kaderi Kibria   +3 more
wiley   +1 more source

The novel regulatory influence of Argonaute 1 on messenger RNA 5‐methylcytosine modification in Arabidopsis thaliana

The Plant Genome, Volume 19, Issue 4, December 2026.
Abstract 5‐Methylcytidine (m5C) modifications play a critical role in RNA metabolism. TRM4B (tRNA‐specific methytransferase 4B) is the only known component of the plant m5C machinery that mediates mRNA (messenger RNA) methylation. To date, no regulators governing site‐specific m5C modifications have been identified, apart from several degenerated ...
Zedi Feng, Xiu Yin, Zhifang Jiang, Jia Yao, Yiling Dong, Xiaoxia Ma, Yijun Meng   +6 more
wiley   +1 more source

Auxin‐related regulation of barley floral organ fate: genetic and phenotypic insights from tweaky spike mutants

New Phytologist, Volume 252, Issue 3, Page 1166-1180, November 2026.
Inflorescence/floret phenotypes of tweaky spike (tw) barley (Hordeum vulgare) mutants and their respective WT backgrounds. Summary Mutant‐based research is a cornerstone for elucidating gene function in barley (Hordeum vulgare) and other cereals. In this study, we exploited a unique collection of barley tweaky spike (tw) mutants to identify the locus ...
Vėjūnė Pukenytė, Bernadeta Kaminskaitė‐Mačė, Miglė Remeikytė, Jurga Jankauskienė, Julius Juodakis, Sigita Jurkonienė, Algė Leistrumaitė, Ljudmilla Timofejeva, Virginija Vaitkūnienė, Justas Stonkus, Raimondas Šiukšta   +10 more
wiley   +1 more source

Nucleolin Alterations and ROS Production Associate With Sensitivity of AML Cells to Venetoclax

The FASEB Journal, Volume 40, Issue 19, 15 October 2026.
Venetoclax‐induced Bcl‐2 inhibition corresponds with Mcl‐1 attenuation and decrease of Nucleolin (NCL) level and activity in sensitive cells. Simultaneously, distinct cell subpopulations with opposite mitochondrial (CellROX label, magenta) and cellular (H2DCFDA stain, green) ROS occur, and the H2DCFDA‐positive population shows markers of early ...
Kateřina Wolfová, Petra Otevřelová, Barbora Brodská   +2 more
wiley   +1 more source

Beta‐Arrestin‐2 Binds to Nucleolar Organizing Regions With P2X7 Receptor Stimulation and During Cell Division

The FASEB Journal, Volume 40, Issue 19, 15 October 2026.
Beta‐Arrestin‐2 but not Beta‐Arrestin‐1 can accumulate in the nucleolus and come in close contact with the Nucleolar Organizing Regions during two distinct processes: P2X7 receptor stimulation (A) and cell division (B). Both seem to be due to loss of nuclear membrane barrier that keeps Beta‐arrestin‐2 out of the nucleus.
Tuğba Gümüştaş, Seda Uysal, Ida Casella, Özlem Uğur, Mehmet Uğur   +4 more
wiley   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, Volume 20, Issue 10, Page 2510-2532, October 2026.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

The dual life of disordered lysine-rich domains of snoRNPs in rRNA modification and nucleolar compaction

Nature Communications
Intrinsically disordered regions (IDRs) are highly enriched in the nucleolar proteome but their physiological role in ribosome assembly remains poorly understood.
Carine Dominique, Nana Kadidia Maiga, Alfonso Méndez-Godoy, Benjamin Pillet, Hussein Hamze, Isabelle Léger-Silvestre, Yves Henry, Virginie Marchand, Valdir Gomes Neto, Christophe Dez, Yuri Motorin, Dieter Kressler, Olivier Gadal, Anthony K. Henras, Benjamin Albert   +14 more
doaj   +1 more source

Recent advances of SNHG in regulating mesenchymal stem cell osteogenic differentiation

Kouqiang hemian waike zazhi
Bone healing and bore regeneration are complex processes in maintaining normal bone homeostasis. Mesenchymal stem cells are main resource of osteoblasts that are responsible for bone formation.
HUANG Jie, WANG Zuolin
doaj   +1 more source

Optical Detection of Cellular Signals at Material Interfaces

Advanced Healthcare Materials, Volume 15, Issue 37, 9 October 2026.
Emerging functional materials are transforming optical detection of cellular signals. This review highlights optical techniques that exploit the unique optical properties of diverse materials to detect and quantify cellular electrical, chemical, and mechanical signals, and discusses key opportunities and challenges.
Xuchen Ren, Jitong Ren, Zixin Zhang, Koney Eungkon Kim, Francis L. Hong, Yuecheng Peter Zhou   +5 more
wiley   +1 more source

Oxygen therapy enhances the systemic inflammatory response in a human model of experimental inflammation

International Journal of Cardiology: Heart & Vasculature
Introduction: Oxygen therapy does not benefit normoxemic patients with suspected myocardial infarction and may instead enhance the inflammatory response triggered by the tissue necrosis caused by the myocardial infarction. In the present study, we tested
P. Tornvall, P. Svensson, J. Alfredsson, L. Jonasson, L. Nilsson, R. Hofmann, SK. Merid   +6 more
doaj   +1 more source