Systematic pan-cancer analysis on the expression and role of regulator of chromatin condensation 1/small nucleolar RNA host gene 3/small nucleolar RNA host gene 12 [PDF]
Frontiers in Molecular Biosciences, 2022 Regulator of chromatin condensation 1 (RCC1) is the major guanine nucleotide exchange factor of RAN GTPase, which plays a key role in various biological processes such as cell cycle and DNA damage repair. Small nucleolar RNA host gene 3 (SNHG3) and small
Kai Hu +4 more
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Characterization of small nucleolar RNA retaining transcripts in human normal and cancer cells [PDF]
Non-coding RNA ResearchSmall nucleolar RNAs are non-coding RNAs typically encoded within the introns of both protein-coding and non-coding genes. Interestingly, a significant fraction of snoRNA sequences is found as retained introns of specific mRNA isoforms expressed from ...
Guglielmo Rambaldelli +10 more
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Small but strong: the emerging role of small nucleolar RNA in cardiovascular diseases [PDF]
Frontiers in Cell and Developmental Biology, 2023 Cardiovascular diseases (CVDs) are the leading cause of mortality and disability worldwide. Numerous studies have demonstrated that non-coding RNAs (ncRNAs) play a primary role in CVD development.
Xue Sun +11 more
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Systematic mapping of small nucleolar RNA interactions in human cells [PDF]
RNA BiologyAltered expression of box C/D small nucleolar RNAs (snoRNAs) is implicated in human diseases, including cancer. Box C/D snoRNAs canonically direct site-specific, 2’-O-methylation but the extent to which they participate in other functions remains unclear.
Hywel Dunn-Davies +5 more
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Small Nucleolar RNA from S. cerevisiae Binds to Phosphatidylinositol 4,5-Bisphosphate [PDF]
Non-Coding RNABackground: snoRNAs have traditionally been known for their role as guides in post-transcriptional rRNA modifications. Previously, our research group identified several RNAs that may bind to PIP2 with LIPRNA-seq.
Irma A. Jiménez-Ramírez +3 more
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Small Nucleolar (Sno)RNA: Therapy Lays in Translation
Non-Coding RNA, 2023 The ribosome is one of the largest complexes in the cell. Adding to its complexity are more than 200 RNA modification sites present on ribosomal RNAs (rRNAs) in a single human ribosome.
Ofri Rabany, Daphna Nachmani
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Small nucleolar RNA dysregulation and potential roles in bovine subclinical mastitis [PDF]
Journal of Animal Science and BiotechnologyBackground Subclinical mastitis, caused by many pathogens including Staphylococcus aureus (S. aureus) and Staphylococcus chromogenes (S. chromogenes), presents a major challenge to the dairy industry due to its associated economic losses and poor milk ...
Faith A. Omonijo +6 more
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Are Small Nucleolar RNAs “CRISPRable”? A Report on Box C/D Small Nucleolar RNA Editing in Human Cells [PDF]
Frontiers in Pharmacology, 2019 CRISPR technologies are nowadays widely used for targeted knockout of numerous protein-coding genes and for the study of various processes and metabolic pathways in human cells. Most attention in the genome editing field is now focused on the cleavage of
Julia A. Filippova +15 more
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Enabling factor for cancer hallmark acquisition: Small nucleolar RNA host gene 17 [PDF]
Frontiers in Oncology, 2022 The role of long non-coding RNA (lncRNA) in human tumors has gradually received increasing attention in recent years. Particularly, the different functions of lncRNAs in different subcellular localizations have been widely investigated.
Ningzhi Zhang +4 more
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U8 variants on the brain: a small nucleolar RNA and human disease [PDF]
RNA Biology, 2022 Small nucleolar RNAs (snoRNAs) are non-coding RNAs vital for ribosomal RNA (rRNA) maturation. The U8 snoRNA, encoded by the SNORD118 gene in humans, is an atypical C/D box snoRNA as it promotes rRNA cleavage rather than 2′–O–methylation and is unique to ...
Emily J. McFadden, Susan J. Baserga
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