Results 11 to 20 of about 62,138 (272)

Small Nucleolar (Sno)RNA: Therapy Lays in Translation

Non-Coding RNA, 2023
The ribosome is one of the largest complexes in the cell. Adding to its complexity are more than 200 RNA modification sites present on ribosomal RNAs (rRNAs) in a single human ribosome.
Ofri Rabany, Daphna Nachmani
doaj   +3 more sources

Are Small Nucleolar RNAs “CRISPRable”? A Report on Box C/D Small Nucleolar RNA Editing in Human Cells [PDF]

Frontiers in Pharmacology, 2019
CRISPR technologies are nowadays widely used for targeted knockout of numerous protein-coding genes and for the study of various processes and metabolic pathways in human cells. Most attention in the genome editing field is now focused on the cleavage of
Julia A. Filippova, Anastasiya M. Matveeva, Anastasiya M. Matveeva, Evgenii S. Zhuravlev, Evgenia A. Balakhonova, Daria V. Prokhorova, Daria V. Prokhorova, Sergey J. Malanin, Raihan Shah Mahmud, Tatiana V. Grigoryeva, Ksenia S. Anufrieva, Ksenia S. Anufrieva, Dmitry V. Semenov, Valentin V. Vlassov, Grigory A. Stepanov, Grigory A. Stepanov   +15 more
doaj   +4 more sources

Small Nucleolar RNA [PDF]

, 2020
Joanna R. Pieńkowska
openalex   +2 more sources

Nucleolar localization signals of Box H/ACA small nucleolar RNAs [PDF]

The EMBO Journal, 1999
The two major families of small nucleolar RNAs (snoRNAs), Box C/D and Box H/ACA, are generated in the nucleoplasm and transported to the nucleolus where they function in rRNA processing and modification. We have investigated the sequences involved in the intranuclear transport of Box H/ACA snoRNAs by assaying the localization of injected fluorescent ...
Aakaash Narayanan
openalex   +4 more sources

Commuting to Work: Nucleolar Long Non-Coding RNA Control Ribosome Biogenesis from Near and Far

Non-Coding RNA, 2021
Gene expression is an essential process for cellular growth, proliferation, and differentiation. The transcription of protein-coding genes and non-coding loci depends on RNA polymerases.
Victoria Mamontova, Barbara Trifault, Lea Boten, Kaspar Burger   +3 more
doaj   +1 more source

Small Nucleolar Derived RNAs as Regulators of Human Cancer

Biomedicines, 2022
In the past decade, RNA fragments derived from full-length small nucleolar RNAs (snoRNAs) have been shown to be specifically excised and functional.
Alexander Bishop Coley, Jeffrey David DeMeis, Neil Yash Chaudhary, Glen Mark Borchert   +3 more
doaj   +1 more source

Expression and Regulatory Network Analysis of Function of Small Nucleolar RNA Host Gene 4 in Hepatocellular Carcinoma. [PDF]

J Clin Transl Hepatol, 2022
Cao J, Xiao C, Fong CTH, Gong J, Li D, Li X, Jie Y, Chong Y.   +7 more
europepmc   +3 more sources

Mammalian small nucleolar RNAs are mobile genetic elements

PLoS Genetics, 2005
Small nucleolar RNAs (snoRNAs) of the H/ACA box and C/D box categories guide the pseudouridylation and the 2'-O-ribose methylation of ribosomal RNAs by forming short duplexes with their target. Similarly, small Cajal body-specific RNAs (scaRNAs) guide modifications of spliceosomal RNAs. The vast majority of vertebrate sno/scaRNAs are located in introns
Michel Weber
openalex   +5 more sources

Small nucleolar RNA host gene 18 controls vascular smooth muscle cell contractile phenotype and neointimal hyperplasia. [PDF]

Cardiovasc Res
Niu K, Zhang C, Yang M, Maguire EM, Shi Z, Sun S, Wu J, Liu C, An W, Wang X, Gao S, Ge S, Xiao Q.   +12 more
europepmc   +3 more sources

sdRNA-D43 derived from small nucleolar RNA snoRD43 improves chondrocyte senescence and osteoarthritis progression by negatively regulating PINK1/Parkin-mediated mitophagy pathway via dual-targeting NRF1 and WIPI2. [PDF]

Cell Commun Signal
Deng Z, Li C, Hu S, Zhong Y, Li W, Lin Z, Mo X, Li M, Xu D, Long D, Mao G, Kang Y.   +11 more
europepmc   +2 more sources