Results 21 to 30 of about 37,390 (195)
Small RNA signatures of the anterior cruciate ligament from patients with knee joint osteoarthritis
Frontiers in Molecular Biosciences, 2023 Introduction: The anterior cruciate ligament (ACL) is susceptible to degeneration, resulting in joint pain, reduced mobility, and osteoarthritis development.
Yalda A. Kharaz +6 more
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On the nucleolar size and density in human early granulocytic progenitors, myeloblasts
European Journal of Histochemistry, 2009 Human myeloblasts were studied in bone marrow of patients suffering from chronic phase of chronic myeloid leukaemia to provide more information on the nucleolar diameter in these early granulocytic progenitors. These cells are a convenient model for such
K Smetana +4 more
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Glutamine deficiency in solid tumor cells confers resistance to ribosomal RNA synthesis inhibitors
Nature Communications, 2022 Small molecules that target RNA Polymerase I inhibit ribosome biogenesis to activate p53 through the nucleolar surveillance response pathway. Here, the authors show that p53 induction by ribosome stress is dependent on extracellular glutamine ...
Melvin Pan +17 more
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Ribosomal RNA: Small nucleolar RNAs make their mark [PDF]
Current Biology, 1996 Small nucleolar RNAs direct the location of certain methylations in ribosomal RNA by direct base pairing; although evolutionarily conserved, the physiological significance of these modifications remains unclear.
Peculis, Brenda A., Mount, Stephen M.
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Jouvence a small nucleolar RNA required in the gut extends lifespan in Drosophila
Nature Communications, 2020 Small non-coding RNAs contribute to the regulation of aging. Here the authors identify a small nucleolar RNA, the snoRNA jouvence, which extends the lifespan of fruit flies through its function in the gut, and is conserved in humans.
Stéphanie Soulé +4 more
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Small Nucleolar RNAs: Insight Into Their Function in Cancer [PDF]
Frontiers in Oncology, 2019 Small nucleolar RNAs (SnoRNAs) are a class of non-coding RNAs divided into two classes: C/D box snoRNAs and H/ACA box snoRNAs. The canonical function of C/D box and H/ACA box snoRNAs are 2'-O-ribose methylation and pseudouridylation of ribosomal RNAs (rRNAs), respectively.
Junnan Liang +5 more
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Human snoRNA-93 is processed into a microRNA-like RNA that promotes breast cancer cell invasion
npj Breast Cancer, 2017 RNA: Small nucleolar-derived RNA contributes to tumor invasiveness A short microRNA-like fragment excised from a small nucleolar RNA (called a snoRNA-derived RNA or sdRNA) contributes to the invasiveness of breast cancer cells.
Dillon G. Patterson +23 more
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Cell Reports, 2017 Non-coding RNA biogenesis in higher eukaryotes has not been fully characterized. Here, we studied the Drosophila melanogaster Rexo5 (CG8368) protein, a metazoan-specific member of the DEDDh 3′-5′ single-stranded RNA exonucleases, by genetic, biochemical,
Stefanie Gerstberger +8 more
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Open Life Sciences, 2020 Osteosarcoma is a common primary malignant bone cancer. Long noncoding RNA small nucleolar RNA host gene 15 (SNHG15) has been reported to play an oncogenic role in many cancers.
Zhang Jinshan +5 more
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Functional diversity of small nucleolar RNAs
Nucleic Acids Research, 2019 AbstractSmall nucleolar RNAs (snoRNAs) are short non-protein-coding RNAs with a long-recognized role in tuning ribosomal and spliceosomal function by guiding ribose methylation and pseudouridylation at targeted nucleotide residues of ribosomal and small nuclear RNAs, respectively.
Boris Rogelj +2 more
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