Results 11 to 20 of about 37,390 (195)
Are Small Nucleolar RNAs “CRISPRable”? A Report on Box C/D Small Nucleolar RNA Editing in Human Cells [PDF]
Frontiers in Pharmacology, 2019 CRISPR technologies are nowadays widely used for targeted knockout of numerous protein-coding genes and for the study of various processes and metabolic pathways in human cells. Most attention in the genome editing field is now focused on the cleavage of
Julia A. Filippova +15 more
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Small Nucleolar RNAs in Pseudoexfoliation Glaucoma
Cells, 2022 Small nucleolar RNAs (snoRNAs) are small non-coding regulatory RNAs that have been investigated extensively in recent years. However, the relationship between snoRNA and glaucoma is still unknown. This study aims to analyze the levels of snoRNA expression in the aqueous humor (AH) of patients with pseudoexfoliation glaucoma (PEXG) compared to a control
Karolina Gasińska +5 more
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Small Nucleolar (Sno)RNA: Therapy Lays in Translation
Non-Coding RNA, 2023 The ribosome is one of the largest complexes in the cell. Adding to its complexity are more than 200 RNA modification sites present on ribosomal RNAs (rRNAs) in a single human ribosome.
Ofri Rabany, Daphna Nachmani
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A non-canonical role for a small nucleolar RNA in ribosome biogenesis and senescence [PDF]
CellJoshua T Mendell +2 more
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BMAL1 Associates with NOP58 in the Nucleolus and Contributes to Pre-rRNA Processing
iScience, 2020 Summary: The transcription factor BMAL1 is a core element of the circadian clock that contributes to cyclic control of genes transcribed by RNA polymerase II.
Marlene Cervantes +5 more
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The epitranscriptome of small non-coding RNAs
Non-coding RNA Research, 2021 Small non-coding RNAs are short RNA molecules and involved in many biological processes, including cell proliferation and differentiation, immune response, cell death, epigenetic regulation, metabolic control.
Xiaoyu Li, Jinying Peng, Chengqi Yi
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Evolution of small nucleolar RNAs in nematodes [PDF]
Nucleic Acids Research, 2006 In contrast to mRNAs, which are templates for translating proteins, non-protein coding (npc) RNAs (also known as 'non-coding' RNA, ncRNA), exhibit various functions in different compartments and developmental stages of the cell. Small nucleolar RNAs (snoRNAs), one of the largest classes of npcRNAs, guide post-transcriptional modifications of other RNAs
Zemann, Anja +4 more
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Heliyon, 2023 Cuproptosis is a novel form of programmed cell death. The role and mechanism of cuproptosis-related genes in prostate adenocarcinoma have not been fully understood. In this study, a series of bioinformatic analyses were performed.
Shuyuan Xiao, Weiyang Lou
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Bidirectional nucleolar dysfunction in C9orf72 frontotemporal lobar degeneration
Acta Neuropathologica Communications, 2017 An intronic GGGGCC expansion in C9orf72 is the most common known cause of both frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). The repeat expansion leads to the generation of sense and antisense repeat RNA aggregates and
Sarah Mizielinska +9 more
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FEBS Open Bio, 2014 Micro RNAs (miRNA) are non-coding RNAs expressed in the cytoplasm as their mature, 21–22-nucleotide short forms. More recently, mature miRNAs have also been detected in the nucleus, raising the possibility that their spatial distribution may be more ...
Baoyan Bai, Hester Liu, Marikki Laiho
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