Results 201 to 210 of about 60,360 (226)
Some of the next articles are maybe not open access.
The many faces of small nucleolar RNAs
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2014Small nucleolar RNAs (snoRNAs) are a class of evolutionally conserved non-coding RNAs traditionally associated with nucleotide modifications in other RNA species. Acting as guides pairing with ribosomal (rRNA) and small nuclear RNAs (snRNAs), snoRNAs direct partner enzymes to specific sites for uridine isomerization or ribose methylation, thereby ...
Tomaž Bratkovič, Boris Rogelj
openaire +2 more sources
Biology and applications of small nucleolar RNAs
Cellular and Molecular Life Sciences, 2011Small nucleolar RNAs (snoRNAs) constitute a group of non-coding RNAs principally involved in posttranscriptional modification of ubiquitously expressed ribosomal and small nuclear RNAs. However, a number of tissue-specific snoRNAs have recently been identified that apparently do not target conventional substrates and are presumed to guide processing of
Tomaž, Bratkovič, Boris, Rogelj
openaire +2 more sources
Small Nucleolar RNA Expression Profiling in Cartilage
2020Osteoarthritis (OA) presents as a change in the articular chondrocyte phenotype. The origin of the phenotype change is poorly understood. Small nucleolar RNAs (snoRNAs) direct chemical modification of other RNA substrates and are involved in endoribonucleolytic pre-rRNA processing.
Peffers, Mandy J +2 more
openaire +2 more sources
Small nucleolar RNAs and RNA-guided post-transcriptional modification
Essays in Biochemistry, 2013snoRNAs (small nucleolar RNAs) constitute one of the largest and best-studied classes of non-coding RNAs that confer enzymatic specificity. With associated proteins, these snoRNAs form ribonucleoprotein complexes that can direct 2′-O-methylation or pseudouridylation of target non-coding RNAs.
Lauren, Lui, Todd, Lowe
openaire +2 more sources
Expression of small nucleolar RNAs in leukemic cells
Cellular Oncology, 2012Small nucleolar RNAs (snoRNAs) direct sequence-specific modifications to ribosomal RNA. We hypothesized that the expression of snoRNAs may be altered in leukemic cells.The expression of snoRNAs was analyzed in various leukemic cell lines by massive parallel sequencing (SOLiD).
Uusimäki Annemari +6 more
openaire +2 more sources
Probing RNA in Vivo with Methylation Guide Small Nucleolar RNAs
Methods, 2001Most box C/D small nucleolar RNAs (snoRNAs) direct the formation of 2'-O-methylated nucleotides in ribosomal RNA and, apparently, other RNAs present in the nucleolar complex. Sites to be modified are selected by a long (>10-nt) antisense guide sequence in the snoRNA and a distance measurement from a box D or D' element that follows the snoRNA guide ...
B, Liu, J, Ni, M J, Fournier
openaire +2 more sources
Deep Sequencing Analysis of Nucleolar Small RNAs: Bioinformatics
2016Small RNAs (size 20-30 nt) of various types have been actively investigated in recent years, and their subcellular compartmentalization and relative concentrations are likely to be of importance to their cellular and physiological functions. Comprehensive data on this subset of the transcriptome can only be obtained by application of high-throughput ...
Baoyan, Bai, Marikki, Laiho
openaire +2 more sources
Implications of Small Nucleolar RNA-Protein Complexes Discoveries
Recent Patents on DNA & Gene Sequences, 2008Small nucleolar RNA molecules (snoRNA) comprise a special kind of non-coding RNAs involved in the maturation process of rRNAs, snRNAs, tRNAs and mRNAs. Traditionally, these molecules have been divided into two families depending on the type of conserved boxes that they harbour: box C/D and H/ACA snoRNAs.
openaire +2 more sources
Targeting RNA structures with small molecules
Nature Reviews Drug Discovery, 2022Matthew D Disney +2 more
exaly